GB887748A - Dihydroxy steroids - Google Patents

Dihydroxy steroids

Info

Publication number
GB887748A
GB887748A GB38926/59A GB3892659A GB887748A GB 887748 A GB887748 A GB 887748A GB 38926/59 A GB38926/59 A GB 38926/59A GB 3892659 A GB3892659 A GB 3892659A GB 887748 A GB887748 A GB 887748A
Authority
GB
United Kingdom
Prior art keywords
alkali metal
alkanoyloxy
hydroxy
steroids
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB38926/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of GB887748A publication Critical patent/GB887748A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises compounds having the formula <FORM:0887748/IV (b)/1> in which R is a lower alkanoyl radical <FORM:0887748/IV (b)/2> is the trivalent radical <FORM:0887748/IV (b)/3> or <FORM:0887748/IV (b)/4> and -C1-C2- is the divalent radical -CH2-CH2- or -CH=CH-and a process for preparing 16a 17a -dihydroxy steroids of the pregnane series characterised by treating a 16b -hydroxy (or alkanoyloxy)-17a -hydroxy (or alkanoyloxy) steroid of the pregnane series with a base e.g. an alkali metal hydroxide an alkali metal carbonate an alkali metal bicarbonate or an alkali metal alkoxide. The starting 16b -alkanoyloxy 17a -hydroxy steroids may be obtained by reacting a 16a -epoxy steroid with an alkanoic acid and an acidic reagent, e.g. a mixture of sulphuric and acetic acids. Specification 824,351 is referred to.
GB38926/59A 1958-11-17 1959-11-17 Dihydroxy steroids Expired GB887748A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US887748XA 1958-11-17 1958-11-17

Publications (1)

Publication Number Publication Date
GB887748A true GB887748A (en) 1962-01-24

Family

ID=22213373

Family Applications (1)

Application Number Title Priority Date Filing Date
GB38926/59A Expired GB887748A (en) 1958-11-17 1959-11-17 Dihydroxy steroids

Country Status (1)

Country Link
GB (1) GB887748A (en)

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