GB880992A - Compounds of kanamycin and tetracycline type antibiotic - Google Patents
Compounds of kanamycin and tetracycline type antibioticInfo
- Publication number
- GB880992A GB880992A GB34181/59A GB3418159A GB880992A GB 880992 A GB880992 A GB 880992A GB 34181/59 A GB34181/59 A GB 34181/59A GB 3418159 A GB3418159 A GB 3418159A GB 880992 A GB880992 A GB 880992A
- Authority
- GB
- United Kingdom
- Prior art keywords
- kanamycin
- tetracycline
- compounds
- prepared
- tetracyclylmethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
Abstract
Compounds of kanamycin and a tetracycline are produced by reacting 1 mol of kanamycin with one to four moles of (a) formaldehyde or a polymer thereof and (b) one to four mols of tetracycline, 5-oxytetracycline, 7-chlorotetracycline, anhydrotetracycline, 7-bromotetracycline, 6-deoxytetracycline or 6-demethyldeoxytetracycline. The compounds are prepared by adding an aqueous solution of kanamycin to a solution of the tetracycline and formaldehyde in a water-miscible organic solvent such as methanol or ethylene glycol monomethyl ether. The kanamycin may be kanamycin A or B, a naturally produced mixture of A and B or a prepared mixture of A and B. The compounds are monoditri- or tetra- N1-tetracyclylmethyl kanamycins wherein, in the case of tetracycline, the N1-tetracyclylmethyl radical has the formula <FORM:0880992/IV (b)/1> a kanamycin molecule being bound to one to four tetracycline molecules through one to four methylene groups, which are attached both to the nitrogen atom of a primary amino group of kanamycin and to the nitrogen atom of the carboxamido group of the tetracycline. The non-toxic acid addition salts may be prepared from these compounds by conventional means. Specification 817,385 is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US880992XA | 1958-10-10 | 1958-10-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB880992A true GB880992A (en) | 1961-11-01 |
Family
ID=22209363
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB34181/59A Expired GB880992A (en) | 1958-10-10 | 1959-10-08 | Compounds of kanamycin and tetracycline type antibiotic |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB880992A (en) |
-
1959
- 1959-10-08 GB GB34181/59A patent/GB880992A/en not_active Expired
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