GB873206A - Improvements in or relating to pharmaceutical compositions - Google Patents

Improvements in or relating to pharmaceutical compositions

Info

Publication number
GB873206A
GB873206A GB2433057A GB2433057A GB873206A GB 873206 A GB873206 A GB 873206A GB 2433057 A GB2433057 A GB 2433057A GB 2433057 A GB2433057 A GB 2433057A GB 873206 A GB873206 A GB 873206A
Authority
GB
United Kingdom
Prior art keywords
diiodo
hydroxyphenoxy
acid
methoxyphenoxy
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2433057A
Inventor
William Francis Ja Cuthbertson
Dennis Martin Ireland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB2433057A priority Critical patent/GB873206A/en
Publication of GB873206A publication Critical patent/GB873206A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Pharmaceutical compositions in unit dosage form e.g. a tablet, capsule or cachet, comprise a solid, non-toxic, orally-injestible carrier and at least 1 mg. and not more than 100 mg. of one or a mixture of more than one of: 3 : 5-diiodo-4-(41-hydroxyphenoxy)-phenylacetic acid; 3 : 5-dibromo - 4 - (41 - hydroxyphenoxy) - phenylacetic acid; 3 : 5-diiodothyronamine (b -[3 : 5-diiodo - 4 - (41 - hydroxyphenoxy]) - phenyl ethylamine; 3 : 5-diiodo-4-(41-hydroxyphenoxy) benzoic acid; salts and simple derivatives thereof, e.g. O-acyl and N-acyl derivatives, methyl ethers, ethyl esters thereof and non-toxic metallic salts of these compounds. The dosage units preferably contain from 1 to 40 mg. of the active substance, particularly 1-25 mg. and especially 1-15 mg. Other related compounds stated in the Provisional Specification to have similar activity are: thyroxamine, L - 3 : 5 - dibromothyronine, L - 3 : 5 - dichlorothyronine, L - 3 : 5 : 3 : 51 - tetrabromothyronine, 3 : 5 - diiodo - 4 - (41 - hydroxyphenoxy) - phenylpropionic acid, 3 : 5 - diiodo - 4 - (41 - hydroxyphenoxy) - cinnamic acid, L - 3 : 5 - diiodo - 4 - (41 - methoxyphenoxy) - phenylalanine and 3 : 5 - diiodo - 4 - (41 - methoxyphenoxy) - N-acetyl-phenylalanine ethyl ester.
GB2433057A 1957-07-31 1957-07-31 Improvements in or relating to pharmaceutical compositions Expired GB873206A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2433057A GB873206A (en) 1957-07-31 1957-07-31 Improvements in or relating to pharmaceutical compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2433057A GB873206A (en) 1957-07-31 1957-07-31 Improvements in or relating to pharmaceutical compositions

Publications (1)

Publication Number Publication Date
GB873206A true GB873206A (en) 1961-07-19

Family

ID=10210014

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2433057A Expired GB873206A (en) 1957-07-31 1957-07-31 Improvements in or relating to pharmaceutical compositions

Country Status (1)

Country Link
GB (1) GB873206A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007059039A1 (en) * 2005-11-11 2007-05-24 Oregon Health & Science University Thyroxine derivatives for preconditioning against stroke

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007059039A1 (en) * 2005-11-11 2007-05-24 Oregon Health & Science University Thyroxine derivatives for preconditioning against stroke

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