GB864718A - Improvements in or relating to the purification of bacitracin - Google Patents
Improvements in or relating to the purification of bacitracinInfo
- Publication number
- GB864718A GB864718A GB19774/59A GB1977459A GB864718A GB 864718 A GB864718 A GB 864718A GB 19774/59 A GB19774/59 A GB 19774/59A GB 1977459 A GB1977459 A GB 1977459A GB 864718 A GB864718 A GB 864718A
- Authority
- GB
- United Kingdom
- Prior art keywords
- resins
- amberlite
- bacitracin
- acid groups
- sulphonic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
- C07K7/62—Polymyxins; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Bacitracin is purified by passing an aqueous solution of bacitracin having a pH of 2 to 10 through a strongly acidic cation exchange resin and a weakly basic anion exchange resin, the bacitracin being neither absorbed on said resins nor eluted therefrom, and drying the resulting solution to obtain solid bacitracin. A fermentation broth is clarified and the pH adjusted first to pH 3,5 and then to pH 7,5 to precipitate impurities. The exchange resins are in the free acid and free base form. The aqueous solution of bacitracin may be passed down a column of exchange resin in any order or simultaneously i.e. a column of mixed resins may be used. The cation exchange resins may be those which contain nuclear sulphonic acid groups or methylene sulphonic acid groups e.g. phenol formaldehyde resins containing nuclear sulphonic acid groups or sulphonated aromatic hydrocarbon polymers such as sulphonated polystyrene resins e.g. " Amberlite " (Registered Trade Mark) 1R-120. The anion exchange resins are weak amine or mixed amine type phenol formaldehyde resins e.g. Amberlite 1R-4B and Amberlite 1R-45. Mixed resins are Amberlite MB-4, a mixture of Amberlite 1R-120 and Amberlite 1R-45.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB19774/59A GB864718A (en) | 1959-06-09 | 1959-06-09 | Improvements in or relating to the purification of bacitracin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB19774/59A GB864718A (en) | 1959-06-09 | 1959-06-09 | Improvements in or relating to the purification of bacitracin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB864718A true GB864718A (en) | 1961-04-06 |
Family
ID=10135003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB19774/59A Expired GB864718A (en) | 1959-06-09 | 1959-06-09 | Improvements in or relating to the purification of bacitracin |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB864718A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105504020A (en) * | 2016-01-23 | 2016-04-20 | 雅赛利(台州)制药有限公司 | Pharmaceutical grade bacitracin and preparing device thereof |
-
1959
- 1959-06-09 GB GB19774/59A patent/GB864718A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105504020A (en) * | 2016-01-23 | 2016-04-20 | 雅赛利(台州)制药有限公司 | Pharmaceutical grade bacitracin and preparing device thereof |
| CN105504020B (en) * | 2016-01-23 | 2019-12-20 | 雅赛利(台州)制药有限公司 | Pharmaceutical grade bacitracin and preparation device thereof |
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