GB863489A - Improvements in or relating to steroids and the manufacture thereof - Google Patents
Improvements in or relating to steroids and the manufacture thereofInfo
- Publication number
- GB863489A GB863489A GB22821/57A GB2282157A GB863489A GB 863489 A GB863489 A GB 863489A GB 22821/57 A GB22821/57 A GB 22821/57A GB 2282157 A GB2282157 A GB 2282157A GB 863489 A GB863489 A GB 863489A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbon atoms
- tetrahydroxy
- etherified
- glycol
- containing less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises: (a) compounds of the general formula: <FORM:0863489/IV (b)/1> wherein R1O. AcO and -O-R2-O- represent respectively hydrocarbonoxy, hydrocarboyloxy and hydrocarbon a , b -glycol radicals, each containing less than 12 carbon atoms; (b) a process for producing 19-norhydrocortisone comprising reducing a 3-etherified 3, 11b , 17a , 21-tetrahydroxy-19-nor- 1, 3, 5(10)-pregnatiren-20-one 20-cyclic ketal (II, wherein R1O represents any ether radical containing less than 12 carbon atoms and -O-R2-O- the radical of any glycol having less than 2 carbon atoms between the carbinol groups and containing less than 12 carbon atoms) by means of lithium, an alcohol and liquid ammonia, to produce a 3-etherified 3-, 11b , 17a , 21-tetrahydroxy-19-nor-2, 5(10)- pregnadien-20-one 20-cyclic ketal (III, wherein R1O and -O-R2-O- have the meanings given immediately above), and heating the latter compound with an acid hydrolysing agent; (c) the combination of process (b) with the preparation of the starting materials by heating an appropriate 3-etherified 3, 11b , 17a , 21-tetrahydroxy-19-nor-1, 3, 5(10)-pregnatrien-20-one (I) or an 11b -acyl derivative thereof (Ia) with an appropriate glycol and an acid catalyst, followed, in the case of the 11b -acyloxy compound, by reductive hydrolysis with a metal hydride. Specification 863,313 is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US863489XA | 1956-08-21 | 1956-08-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB863489A true GB863489A (en) | 1961-03-22 |
Family
ID=22197997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB22821/57A Expired GB863489A (en) | 1956-08-21 | 1957-07-18 | Improvements in or relating to steroids and the manufacture thereof |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB863489A (en) |
-
1957
- 1957-07-18 GB GB22821/57A patent/GB863489A/en not_active Expired
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB996080A (en) | 17-monoesters of 17ª,21-dihydroxy steroids and process for the preparation thereof | |
GB863489A (en) | Improvements in or relating to steroids and the manufacture thereof | |
GB1058543A (en) | 16-methylene-steroids | |
ES312786A1 (en) | Intermediates in the preparation of 17alpha-ethynyl-19-nor steroids | |
ES427480A1 (en) | Corticoid-containing inhalant preparations | |
GB761974A (en) | Isomorphinane derivatives | |
GB934148A (en) | Improvements in or relating to steroids and the manufacture thereof | |
GB1094810A (en) | Unsaturated 4,5-seco-steroid compounds, and processes for their preparation | |
ES447636A1 (en) | Process for manufacture of 3,5-ditert.butyl-4-hydroxybenzaldehyde from 3,5-ditert.butyl-4-hydroxybenzyl alcohol | |
GB1028154A (en) | Substituted pregnenes, pregnadienes and methods of preparing the same | |
GB1244111A (en) | PROCESS FOR THE PREPARATION OF 17alpha-DIHYDROEQUILENIN AND RELATED COMPOUNDS | |
GB1067345A (en) | Novel steroid compounds, processes for preparing them and compositions containing them | |
GB950899A (en) | Improvements in or relating to steroidal alkyl ethers | |
GB850386A (en) | Cyclopentanophenanthrene derivatives and processes for the production thereof | |
GB878725A (en) | Pregnenolone derivatives and processes for their production | |
GB1069709A (en) | New steroid compounds,compositions incorporating them,and processes for their preparation | |
GB739597A (en) | Steroid ketals | |
GB948631A (en) | Cyclopentanophenanthrene derivatives and process for their production | |
GB1120495A (en) | A process for the preparation of unsaturated steroids | |
GB772832A (en) | Improvements on or relating to process of production of hydroxylamine salts | |
GB957542A (en) | Cycloalkenyl ethers of 17ª‰-hydroxy androstanes | |
ES435139A1 (en) | Preparation of 2-aminomethyl-pyrrolidine | |
GB1045235A (en) | New steroid[2,3-c]furazan compounds and preparation of the same | |
GB747097A (en) | Steroids | |
GB923531A (en) | Steroids |