ES427480A1 - Corticoid-containing inhalant preparations - Google Patents

Corticoid-containing inhalant preparations

Info

Publication number
ES427480A1
ES427480A1 ES427480A ES427480A ES427480A1 ES 427480 A1 ES427480 A1 ES 427480A1 ES 427480 A ES427480 A ES 427480A ES 427480 A ES427480 A ES 427480A ES 427480 A1 ES427480 A1 ES 427480A1
Authority
ES
Spain
Prior art keywords
general formula
group
oxidizing
formula
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES427480A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES427480A1 publication Critical patent/ES427480A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedure for the preparation of an inhalation agent containing corticosteroids, characterized in that a corticoid of the general formula I is prepared as an active substance **(See formula)** where -BA- means the -CH2-CH2-, -CH = CH- or -CCl = CH- groupings, X means a hydrogen atom, a fluorine atom or a methyl group, Y means a hydrogen atom, a fluorine atom or a chlorine atom, Z means a methylene group, a hydroxymethylan group, a fluoromethylene group, a cloxaroethylene group or a corbonyl group, R1 means a hydrogen atom or a methyl group, and R2 means a hydrogen atom or R1 and R2 together signify an isopropylidenedioxy group; and R3 signifies a hydrocarbon radical with 1 to 12 carbon atoms, a) oxidizing the 20-hydroxy group of compounds of the general formula II **(See formula)** where -AB-, X, Y, Z, R'1, R2 and R2 have the same meanings as in formula I, if desired by oxidizing a free hydroxy group present at position 11, and if desired by saponifying or transesterifying the 21-esters of the general formula I, and transforming into their salts or esterifying the free acids of the general formula I; or b) oxidizing the steroid-aldehydes of the general formula III **(See formula)** where -AB, X, Y, Z, R1 and R2 have the aforementioned meanings or the hydrates, hemiacetals or acetals of these compounds in the presence of alcohols and cyanide ions, with oxides of heavy metals with oxidizing action, if desired oxidizing a free hydroxy group present at position 11, saponifying or transesterifying, if desired, the 21-esters of the general formula I, and transforming into their salts or esterifying the free acids of the general formula I; or c) for the preparation of compounds of the general formula I in which -A-B- has the meaning of a group -CH = CH-, dehydrogenating the compounds of the general formula IV, **(See formula)** where X, Y, Z, R1, R2 and R3 have the aforementioned meanings, if desired by oxidizing a free hydroxy group present in position 11, saponifying or transesterifying eventually the 21-esters of the general formula I, and transforming into their salts or esterifying the free acids of the general formula I; and bringing the corticosteroid of the general formula I thus obtained into a form suitable for inhalation. (Machine-translation by Google Translate, not legally binding)
ES427480A 1973-06-23 1974-06-20 Corticoid-containing inhalant preparations Expired ES427480A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2332663A DE2332663C2 (en) 1973-06-23 1973-06-23 Use of corticosteroid active ingredients for inhalation therapy

Publications (1)

Publication Number Publication Date
ES427480A1 true ES427480A1 (en) 1976-07-16

Family

ID=5885228

Family Applications (1)

Application Number Title Priority Date Filing Date
ES427480A Expired ES427480A1 (en) 1973-06-23 1974-06-20 Corticoid-containing inhalant preparations

Country Status (13)

Country Link
JP (1) JPS6245846B2 (en)
BE (1) BE816709A (en)
DD (1) DD112437A5 (en)
DE (1) DE2332663C2 (en)
DK (1) DK337574A (en)
ES (1) ES427480A1 (en)
FR (1) FR2233987B1 (en)
GB (1) GB1479488A (en)
IE (1) IE39516B1 (en)
IL (1) IL45087A (en)
NL (1) NL184724C (en)
SE (1) SE7408091L (en)
ZA (1) ZA744022B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX3864E (en) * 1975-05-27 1981-08-26 Syntex Corp A PROCESS TO PREPARE THE CRYSTALLINE COMPOUND 6-FLUIRO-11B 21-DIHIROXI-16 17-ISOPROPILIDENDIOXIPREGNA-1 4-DIEN-3 20-DIONA
DE2829953A1 (en) * 1978-07-03 1980-01-24 Schering Ag PHARMACEUTICAL PREPARATION FOR TREATING THE KOLITIS ULCEROSA AND KOLITIS GRANULOMATOSA
US5215979A (en) * 1985-12-19 1993-06-01 Aktiebolaget Draco 16,17-acetalsubstituted pregnane 21-oic acid derivatives
JP4893999B2 (en) * 2004-10-22 2012-03-07 小野薬品工業株式会社 Pharmaceutical composition for inhalation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB799902A (en) * 1954-08-11 1958-08-13 Merck & Co Inc Therapeutic preparations
US3320125A (en) * 1964-04-28 1967-05-16 Merck & Co Inc Inhalation aerosol composition
GB1242211A (en) * 1967-08-08 1971-08-11 Fisons Pharmaceuticals Ltd Pharmaceutical composition
GB1381872A (en) * 1971-06-22 1975-01-29 Fisons Ltd Pharmaceutical compositions for inhalation
BE787100A (en) * 1971-08-06 1973-02-02 Beecham Group Ltd COMPOSITION FOR THE TREATMENT OF ASTHMA
DE2150268C3 (en) * 1971-10-04 1980-11-06 Schering Ag, 1000 Berlin Und 4619 Bergkamen Pregnanic acid derivatives, processes for their preparation and pharmaceuticals containing them
DD95565B1 (en) * 1971-10-04 1986-10-29 Schering Ag PROCESS FOR PREPARING NEW PREGNANEANEUREDERIVATE
DE2264003C2 (en) * 1972-12-22 1982-11-04 Schering Ag, 1000 Berlin Und 4619 Bergkamen New pregnanic acid derivatives, processes for their production and pharmaceutical preparations containing them
DE2319479C2 (en) * 1973-04-14 1982-10-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Pregnanic acid derivatives, processes for their production and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
FR2233987A1 (en) 1975-01-17
AU7042174A (en) 1976-01-08
IE39516L (en) 1974-12-23
DE2332663C2 (en) 1986-07-31
DD112437A5 (en) 1975-04-12
NL184724C (en) 1989-10-16
GB1479488A (en) 1977-07-13
IL45087A0 (en) 1974-09-10
ZA744022B (en) 1975-06-25
IL45087A (en) 1978-04-30
JPS5047967A (en) 1975-04-28
SE7408091L (en) 1974-12-23
NL184724B (en) 1989-05-16
NL7408421A (en) 1974-12-30
IE39516B1 (en) 1978-10-25
JPS6245846B2 (en) 1987-09-29
DE2332663A1 (en) 1975-01-16
BE816709A (en) 1974-12-23
DK337574A (en) 1975-03-17
FR2233987B1 (en) 1977-07-08

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19930210