GB850663A - Substituted piperazines and process for their production - Google Patents

Substituted piperazines and process for their production

Info

Publication number
GB850663A
GB850663A GB23835/59A GB2383559A GB850663A GB 850663 A GB850663 A GB 850663A GB 23835/59 A GB23835/59 A GB 23835/59A GB 2383559 A GB2383559 A GB 2383559A GB 850663 A GB850663 A GB 850663A
Authority
GB
United Kingdom
Prior art keywords
chloro
methyl
carbon atoms
acid
dimethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB23835/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parke Davis and Co LLC
Original Assignee
Parke Davis and Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke Davis and Co LLC filed Critical Parke Davis and Co LLC
Publication of GB850663A publication Critical patent/GB850663A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The invention comprises compounds of the formula : <FORM:0850663/IV(b)/1> (wherein R and R1 are bromine, chlorine, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 5 carbon atoms, or R may additionally be an alkylmercapto group of 1 to 5 carbon atoms, R1 being in the 3- or 5-position) and acid-addition salts thereof; and the preparation thereof by reacting an appropriately disubstituted aniline with diethanolamine in presence of at least a slight excess of a mineral acid, or with an acid addition salt of a bis(haloethyl)amine. Preferably an excess of the aniline compound is employed and the reaction is carried out at elevated temperature. Examples describe the preparation of the 2 : 3-dichloro, 2 : 3-dimethyl, 3-chloro-2-methyl, 2 : 5-dimethyl, 2 : 5-dichloro, 2-methyl-5-chloro, 2-methyl-5-isopropyl, 2 : 3-dimethoxy, 5-chloro-2-isopropoxy, 5-chloro-2-ethylmercapto, 2 : 5-dimethoxy, 2 : 5-diethoxy, 5-chloro-2-methoxy and 2-methoxy-5-methyl compounds of the invention. Hydrochlorides and hydrobromides of some of the products are described and a list of further salt-forming organic and inorganic acids is also provided.
GB23835/59A 1956-10-22 1957-10-21 Substituted piperazines and process for their production Expired GB850663A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US850663XA 1956-10-22 1956-10-22

Publications (1)

Publication Number Publication Date
GB850663A true GB850663A (en) 1960-10-05

Family

ID=22189247

Family Applications (1)

Application Number Title Priority Date Filing Date
GB23835/59A Expired GB850663A (en) 1956-10-22 1957-10-21 Substituted piperazines and process for their production

Country Status (1)

Country Link
GB (1) GB850663A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7872132B2 (en) 2004-10-08 2011-01-18 Suven Life Sciences Limited Intermediates useful for the preparation of aripiprazole and methods for the preparation of the novel intermediates and aripiprazole

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7872132B2 (en) 2004-10-08 2011-01-18 Suven Life Sciences Limited Intermediates useful for the preparation of aripiprazole and methods for the preparation of the novel intermediates and aripiprazole

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