GB849032A - Improvements in and relating to azepine derivatives - Google Patents
Improvements in and relating to azepine derivativesInfo
- Publication number
- GB849032A GB849032A GB20125/58A GB2012558A GB849032A GB 849032 A GB849032 A GB 849032A GB 20125/58 A GB20125/58 A GB 20125/58A GB 2012558 A GB2012558 A GB 2012558A GB 849032 A GB849032 A GB 849032A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- iminostilbenes
- reacting
- represent
- products
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001538 azepines Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- 150000001450 anions Chemical class 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- CPEONABTMRSIKA-UHFFFAOYSA-N 1,4$l^{2}-oxazinane Chemical compound C1COCC[N]1 CPEONABTMRSIKA-UHFFFAOYSA-N 0.000 abstract 1
- WXGBMVAPOXRLDB-UHFFFAOYSA-N 6-(2-phenylethenyl)cyclohexa-2,4-dien-1-imine Chemical class N=C1C=CC=CC1C=CC1=CC=CC=C1 WXGBMVAPOXRLDB-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000002048 spasmolytic effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
The invention comprises compounds of the general formulae: <FORM:0849032/IV(b)/1> and <FORM:0849032/IV(b)/2> and the acid addition salts of I, wherein X1 and X2 represent hydrogen or halogen atoms, R1 and R2 represent alkyl or alkenyl groups containing 1 to 5 carbon atoms or R1 and R2 together with the nitrogen atom represent an alkylene imino radical having 5 or 6 ring members or the morpholino radical, R3 represents an alkyl or alkenyl group containing 1 to 6 carbon atoms or an araliphatic group, Y represents a monovalent anion or a normal equivalent of a polyvalent anion, and n is a whole number from 1 to 5; and the preparation of I by reacting a possibly ring substituted N-halogenoalkanoyliminostilbene of the general formula: <FORM:0849032/IV(b)/3> in which Hal represents chlorine or bromine, with an excess of an amine HNR1R2; and, if desired, converting the products into their acid addition salts; and the preparation of II by treatment of I with a reactive ester of an alcohol R3OH followed, if desired, by exchange of anions of II. The products of formula I have local anaesthetic activity and those of formula II have spasmolytic properties. N-Halogenoalkanoyl-iminostilbenes, are prepared by reacting iminostilbenes with halogenocarboxylic acid halides. Specification 820,476 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH849032X | 1957-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB849032A true GB849032A (en) | 1960-09-21 |
Family
ID=4542112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB20125/58A Expired GB849032A (en) | 1957-06-25 | 1958-06-24 | Improvements in and relating to azepine derivatives |
Country Status (4)
| Country | Link |
|---|---|
| CH (2) | CH358806A (en) |
| DE (1) | DE1124501B (en) |
| GB (1) | GB849032A (en) |
| NL (1) | NL106266C (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE456311A (en) * | 1951-07-11 |
-
0
- NL NL106266D patent/NL106266C/xx active
-
1957
- 1957-06-25 CH CH358806D patent/CH358806A/en unknown
- 1957-06-25 CH CH358805D patent/CH358805A/en unknown
-
1958
- 1958-06-24 DE DEG24808A patent/DE1124501B/en active Pending
- 1958-06-24 GB GB20125/58A patent/GB849032A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1124501B (en) | 1962-03-01 |
| CH358805A (en) | 1961-12-15 |
| CH358806A (en) | 1961-12-15 |
| NL106266C (en) |
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