GB845705A - Improvements in enhancing the potency of adrenocorticotrophin preparations - Google Patents
Improvements in enhancing the potency of adrenocorticotrophin preparationsInfo
- Publication number
- GB845705A GB845705A GB35919/56A GB3591956A GB845705A GB 845705 A GB845705 A GB 845705A GB 35919/56 A GB35919/56 A GB 35919/56A GB 3591956 A GB3591956 A GB 3591956A GB 845705 A GB845705 A GB 845705A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acth
- pyridoxine
- adrenocorticotrophin
- potency
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- A61K38/35—Corticotropin [ACTH]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Adrenocorticotrophin (ACTH) from any mammalian pituitary tissue, especially ovine and bovine ACTH, is enhanced in potency especially as manifested upon subcutaneous administration, by treatment with pyridoxine or a mineral acid salt thereof, preferably pyridoxine hydrochloride, present in a concentration from 0,005% to 10% weight/volume, preferably 1%, at a temperature which may be from 15 DEG C. to 150 DEG C., preferably 90 DEG C.-100 DEG C., at a pH from 3,5 to 5,5, preferably 4,7 to 4,8, which may be obtained by agents such as hydrochloric acid, sodium hydroxide, acetic acid-sodium acetate buffer. Gelatin and p preservatives such as propyl or methyl parahydroxybenzoate or phenol may be added before or after treatment and an organic reducing agent containing at least one sulphhydryl group such as cysteine, b -mercaptoethanol or thioglycollic acid may be added to stabilize the pyridoxine-treated ACTH. Specification 845,704 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US845705XA | 1955-11-28 | 1955-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB845705A true GB845705A (en) | 1960-08-24 |
Family
ID=22185805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB35919/56A Expired GB845705A (en) | 1955-11-28 | 1956-11-23 | Improvements in enhancing the potency of adrenocorticotrophin preparations |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB845705A (en) |
-
1956
- 1956-11-23 GB GB35919/56A patent/GB845705A/en not_active Expired
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