GB843676A - New biguanide salts - Google Patents
New biguanide saltsInfo
- Publication number
- GB843676A GB843676A GB4040257A GB4040257A GB843676A GB 843676 A GB843676 A GB 843676A GB 4040257 A GB4040257 A GB 4040257A GB 4040257 A GB4040257 A GB 4040257A GB 843676 A GB843676 A GB 843676A
- Authority
- GB
- United Kingdom
- Prior art keywords
- substituted
- salts
- aliphatic
- alkyl
- bis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
- C07C279/265—X and Y being nitrogen atoms, i.e. biguanides containing two or more biguanide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises salts of bis-biguanides of the formula: <FORM:0843676/IV(b)/1> (where A is a phenyl radical which may be substituted by alkyl, alkoxy or nitro groups or by halogen; R is hydrogen, alkyl or aralkyl; X is a direct linkage or an alkylene radical of not more than 3 carbon atoms; and m is an integer of 2-12, the polymethylene chain -(CH2)m-being optionally interrupted by oxygen atoms and/or by aromatic nuclei), with C6-C26 aliphatic or olefinic acids or their C-substituted monohydroxy, carboxy or ester derivatives. Suitable bis-biguanides are 1:6-di-(N1:N11-p-chlorophenyl- and p-chlorobenzyl-biguanido-N5:N51)-hexane, and those disclosed in Specifications 705,838 and 785,937. Suitable salt-forming acids are arachidic, stearic, palmitic, lauric, oleic, linoleic, linolenic and ricinoleic acids, and esters of a carboxy-substituted C6-26 aliphatic or olefinic acid with a monohydric alcohol or with a partially esterified polyhydric alcohol. The salts of the invention may be obtained by interacting a C6-26 aliphatic or olefinic acid or a C-substituted derivative thereof, or a salt thereof, with a bis-biguanide of the above formula, or a salt thereof. The salts of the invention are useful as antimicrobial and antifungal agents (see Group VI). Specifications 710,105, 815,800 and 815,925 also are referred to.ALSO:Pharmaceutical and veterinary compositions of antimicrobial and antifungal use contain as active agents one or more salts of bis-biguanides, of the formula: <FORM:0843676/VI/1> (where A is a phenyl radical which may be substituted by alkyl, alkoxy or nitro groups or by halogen; R is hydrogen, alkyl or aralkyl; X is a direct linkage or an alkylene radical of not more than 3 carbon atoms; and n is an integer of 2-12, the polymethylene chain -(CH2)n being optionally interrupted by oxygen atoms and/or aromatic nuclei), with C6-C26 aliphatic or olefinic acids or their C-substituted monohydroxy, carboxy or ester derivatives. Suitable compositions are solutions, suspensions, ointments, powders and the like. Other known antimicrobial and antifungal agents may be incorporated in the compositions. Castor oil is used as a solvent for the active agents in examples, and other specified additives are polyoxyethylene sorbitan monooleate, cetostearyl alcohol and Cetrimide. Specifications 705,838, 710,105, 785,937, 815,800 and 815,925 are referred to.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4040257A GB843676A (en) | 1957-12-31 | 1957-12-31 | New biguanide salts |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4040257A GB843676A (en) | 1957-12-31 | 1957-12-31 | New biguanide salts |
Publications (1)
Publication Number | Publication Date |
---|---|
GB843676A true GB843676A (en) | 1960-08-10 |
Family
ID=10414729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4040257A Expired GB843676A (en) | 1957-12-31 | 1957-12-31 | New biguanide salts |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB843676A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2194694A1 (en) * | 1972-08-01 | 1974-03-01 | Hurka Wilhelm | |
WO1998056253A1 (en) * | 1997-06-13 | 1998-12-17 | Avecia Limited | Biocidal organic acid salts of a polymeric biguanide |
WO2017137818A1 (en) * | 2016-02-12 | 2017-08-17 | Salicylates & Chemicals | Synthesis and application of an antimicrobial active |
-
1957
- 1957-12-31 GB GB4040257A patent/GB843676A/en not_active Expired
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2194694A1 (en) * | 1972-08-01 | 1974-03-01 | Hurka Wilhelm | |
WO1998056253A1 (en) * | 1997-06-13 | 1998-12-17 | Avecia Limited | Biocidal organic acid salts of a polymeric biguanide |
WO1998056252A1 (en) * | 1997-06-13 | 1998-12-17 | Unilever Plc | Composition for use in personal care |
AU742600B2 (en) * | 1997-06-13 | 2002-01-10 | Unilever Plc | Composition for use in personal care |
US6509022B2 (en) | 1997-06-13 | 2003-01-21 | Helene Curtis, Inc. | Composition for use in personal care comprising organic acid salts of polymeric biguanidines |
CN100577142C (en) * | 1997-06-13 | 2010-01-06 | 尤尼利弗公司 | Compositions for use in personal care |
WO2017137818A1 (en) * | 2016-02-12 | 2017-08-17 | Salicylates & Chemicals | Synthesis and application of an antimicrobial active |
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