GB1084996A - Dibenzocyclohepten-5-yl-acetic acid esters - Google Patents

Dibenzocyclohepten-5-yl-acetic acid esters

Info

Publication number
GB1084996A
GB1084996A GB47786/63A GB4778663A GB1084996A GB 1084996 A GB1084996 A GB 1084996A GB 47786/63 A GB47786/63 A GB 47786/63A GB 4778663 A GB4778663 A GB 4778663A GB 1084996 A GB1084996 A GB 1084996A
Authority
GB
United Kingdom
Prior art keywords
formula
alkyl
radical
acid addition
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB47786/63A
Inventor
Cordelis Van Der Stelt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Pharmaceutische Fabrieken NV
Original Assignee
Koninklijke Pharmaceutische Fabrieken NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NL125839D priority Critical patent/NL125839C/xx
Priority to GB47786/63A priority patent/GB1084996A/en
Application filed by Koninklijke Pharmaceutische Fabrieken NV filed Critical Koninklijke Pharmaceutische Fabrieken NV
Priority claimed from US385455A external-priority patent/US3324138A/en
Priority to US385455A priority patent/US3324138A/en
Priority to BR162496/64A priority patent/BR6462496D0/en
Priority to FR990881A priority patent/FR1518578A/en
Priority to IL22359A priority patent/IL22359A/en
Priority to FI2362/64A priority patent/FI42825B/fi
Priority to NO155795A priority patent/NO120680B/no
Priority to BE656483A priority patent/BE656483A/xx
Priority to ES0306937A priority patent/ES306937A1/en
Priority to NL6413980A priority patent/NL6413980A/xx
Priority to DE19641468425 priority patent/DE1468425A1/en
Priority to SE14558/64A priority patent/SE318868B/xx
Priority to CH1554664A priority patent/CH465596A/en
Publication of GB1084996A publication Critical patent/GB1084996A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C07C57/50—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

<FORM:1084996/C2/1> Novel compounds of the Formula I, wherein X represents an ethylene or ethylene radical, each of R1 and R2 represents a hydrogen or halogen atom or a C1- 7 alkyl group and R3 represents (a) a group of the formula -A-B, wherein A represent a C1- 7 alkylene radical and B represents a C1- 7 alkylamino, di-(C1- 7 alkyl) amino, piperidino, pyrrolidino, morpholino or thiamorpholino radical or (b) a group of the Formula II (wherein R4 represents a hydrogen atom or a C1- 7 alkyl group and n represents 1 or 2), or (c) a saturated bicyclic nitrogen-containing heterocyclic radical of less than 12 carbon atoms, optionally carrying a C1- 7 alkyl or aryl-C1- 7 alkyl substituent, and non-toxic acid addition salts thereof, are prepared by reacting in an inert solvent under esterification conditions an acid of the Formula III or a reactive functional derivative thereof with an alcohol of the formula R3OH or by reacting in an inert solvent a salt of said acid with a reactive-functional derivative of said alcohol, and, if desired, converting a resultant product into a non-toxic acid addition salt thereof. Therapeutic compositions with cardiac regulatory properties in forms suitable for oral or parenteral administration comprise compounds of the Formula I or non-toxic acid addition salts thereof in association with pharmaceutically acceptable carriers.
GB47786/63A 1963-12-03 1963-12-03 Dibenzocyclohepten-5-yl-acetic acid esters Expired GB1084996A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
NL125839D NL125839C (en) 1963-12-03
GB47786/63A GB1084996A (en) 1963-12-03 1963-12-03 Dibenzocyclohepten-5-yl-acetic acid esters
US385455A US3324138A (en) 1963-12-03 1964-07-27 Quinuclidin-3-yl-ester of 10, 11-dihydro-5h-dibenzo[a, d]cyclohepten-5-yl-acetic acid
BR162496/64A BR6462496D0 (en) 1963-12-03 1964-09-10 PROCESS TO PREPARE HEPTEY-5-IL-ACETIC DI-BENZO ACID ESTERS
FR990881A FR1518578A (en) 1963-12-03 1964-10-09 Process for the preparation of new esters of dibenzocyclohepten-5-yl-acetic acid
IL22359A IL22359A (en) 1963-12-03 1964-11-01 Dibenzocycloheptenyl acetic acids,their esters,and process for their preparation
FI2362/64A FI42825B (en) 1963-12-03 1964-11-11
NO155795A NO120680B (en) 1963-12-03 1964-11-28
BE656483A BE656483A (en) 1963-12-03 1964-12-01
ES0306937A ES306937A1 (en) 1963-12-03 1964-12-02 Procedure for the preparation of acid steres dibenzociclohepten-5-il-acetico. (Machine-translation by Google Translate, not legally binding)
NL6413980A NL6413980A (en) 1963-12-03 1964-12-02
DE19641468425 DE1468425A1 (en) 1963-12-03 1964-12-02 Process for the preparation of dibenzocyclohepten-5-ylessigic acid esters
SE14558/64A SE318868B (en) 1963-12-03 1964-12-02
CH1554664A CH465596A (en) 1963-12-03 1964-12-02 Process for the preparation of 5H-dibenzocyclohepten- or 10,11-dihydro-5H-dibenzocyclohepten-5-yl-acetic acid esters

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB47786/63A GB1084996A (en) 1963-12-03 1963-12-03 Dibenzocyclohepten-5-yl-acetic acid esters
US385455A US3324138A (en) 1963-12-03 1964-07-27 Quinuclidin-3-yl-ester of 10, 11-dihydro-5h-dibenzo[a, d]cyclohepten-5-yl-acetic acid

Publications (1)

Publication Number Publication Date
GB1084996A true GB1084996A (en) 1967-09-27

Family

ID=26266134

Family Applications (1)

Application Number Title Priority Date Filing Date
GB47786/63A Expired GB1084996A (en) 1963-12-03 1963-12-03 Dibenzocyclohepten-5-yl-acetic acid esters

Country Status (10)

Country Link
BE (1) BE656483A (en)
BR (1) BR6462496D0 (en)
CH (1) CH465596A (en)
DE (1) DE1468425A1 (en)
FI (1) FI42825B (en)
GB (1) GB1084996A (en)
IL (1) IL22359A (en)
NL (2) NL6413980A (en)
NO (1) NO120680B (en)
SE (1) SE318868B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4412999A (en) * 1982-04-14 1983-11-01 Merck & Co., Inc. Anti-emetic esters of cyproheptadine-3-carboxylic acid and structurally related compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4412999A (en) * 1982-04-14 1983-11-01 Merck & Co., Inc. Anti-emetic esters of cyproheptadine-3-carboxylic acid and structurally related compounds

Also Published As

Publication number Publication date
BR6462496D0 (en) 1973-08-07
NO120680B (en) 1970-11-23
DE1468425A1 (en) 1969-05-29
NL125839C (en)
NL6413980A (en) 1965-06-04
BE656483A (en) 1965-04-01
FI42825B (en) 1970-08-03
IL22359A (en) 1968-07-25
SE318868B (en) 1969-12-22
CH465596A (en) 1968-11-30

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