GB833067A - Improvements in or relating to the purification of vitamin b12 - Google Patents

Improvements in or relating to the purification of vitamin b12

Info

Publication number
GB833067A
GB833067A GB21202/57A GB2120257A GB833067A GB 833067 A GB833067 A GB 833067A GB 21202/57 A GB21202/57 A GB 21202/57A GB 2120257 A GB2120257 A GB 2120257A GB 833067 A GB833067 A GB 833067A
Authority
GB
United Kingdom
Prior art keywords
vitamin
phenol
solution
complex
aqueous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB21202/57A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB833067A publication Critical patent/GB833067A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises a crystalline hydrated vitamin B12/phenol complex having the empirical formula C63H88N14O14PCO(R)n(H2O)x\t in which n is 2 or 4, x is an integer from 4 to 11, and R is a phenol, and a process for the production of highly pure vitamin B12 which comprises adding a phenol to an aqueous solution of vitamin B12 containing at least 0.05% by weight of vitamin B12 thereby to form a vitamin B12/phenol complex, the amount of added phenol being less than the solubility limit in the said vitamin B12 solution, but sufficient to render said complex insoluble in the solution, allowing or causing crystallization to proceed, isolating the resulting hydrated vitamin B12/phenol complex crystals, mixing the said crystals with water whereby an aqueous vitamin B12 solution results, precipitating by adding a water-miscible non-solvent for vitamin B12 whereby the said vitamin B12 is precipitated and recovering the resulting highly pure vitamin B12. As phenols there may be used phenol, orcinol, phloroglucinol and hydroquinone. Preferably, the amount of added is less than 3% suitably 1.5 to 2.5% by volume based on the said aqueous vitamin B12 solution. The pure vitamin B12 may be precipitated from its solution after decomposition of the phenol complex by means of acetone or dioxane. Examples describe the formation of complexes using the phenols mentioned above.
GB21202/57A 1956-07-05 1957-07-04 Improvements in or relating to the purification of vitamin b12 Expired GB833067A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR833067X 1956-07-05

Publications (1)

Publication Number Publication Date
GB833067A true GB833067A (en) 1960-04-21

Family

ID=9296350

Family Applications (1)

Application Number Title Priority Date Filing Date
GB21202/57A Expired GB833067A (en) 1956-07-05 1957-07-04 Improvements in or relating to the purification of vitamin b12

Country Status (1)

Country Link
GB (1) GB833067A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0976757A2 (en) * 1998-06-11 2000-02-02 Nippon Mitsubishi Oil Corporation A method of purifying vitamin B12 and/or derivatives thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0976757A2 (en) * 1998-06-11 2000-02-02 Nippon Mitsubishi Oil Corporation A method of purifying vitamin B12 and/or derivatives thereof
EP0976757A3 (en) * 1998-06-11 2001-08-08 Nippon Mitsubishi Oil Corporation A method of purifying vitamin B12 and/or derivatives thereof

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