GB824496A - New alkaloid derivatives and methods of producing same - Google Patents

New alkaloid derivatives and methods of producing same

Info

Publication number
GB824496A
GB824496A GB3554156A GB3554156A GB824496A GB 824496 A GB824496 A GB 824496A GB 3554156 A GB3554156 A GB 3554156A GB 3554156 A GB3554156 A GB 3554156A GB 824496 A GB824496 A GB 824496A
Authority
GB
United Kingdom
Prior art keywords
hydroxy
yohimbane
apoyohimbine
dehydro
carbomethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3554156A
Inventor
Wagn Ole Godtfredsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KNUD ABILDGAARD
Original Assignee
KNUD ABILDGAARD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KNUD ABILDGAARD filed Critical KNUD ABILDGAARD
Priority to GB3554156A priority Critical patent/GB824496A/en
Publication of GB824496A publication Critical patent/GB824496A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention comprises 10-hydroxy-16 -carbomethoxy - D 16 - dehydro - yohimbane, its 3 - epimer, 10 - hydroxy - 16 - carbomethoxy - 17 - methoxy - yohimbane, 18 - hydroxy - 16 - carbomethoxy - D 16 - dehydro - yohimbane, and a process for the preparation of monohydroxy derivatives of yohimbane, 3-epiyohimbane, D 16-dehydro-yohimbane, D 16-dehydro-3-epi-yohimbane, their 16-carbalkoxy-, 17-alkoxy- and 16-carbalkoxy-17-alkoxy-derivatives by adding the alkaloid compound to a culture medium in which is grown under submerged aerobic conditions one of the following fungi: Cunninghamella blakesleana, Rhizopus oryzae, R. arrhizus, R. achlamydosporus, R. chinensis, R. circicans, R. delemar, Mucor griseocyanus, Trichothecium roseum, and Mortierella pusilla, the medium containing the nutritional requirements for the growth of fungi of the family Mucoraceae, and isolating the hydroxylated alkaloid which is formed. Detailed examples illustrate the preparation of 10 - hydroxy - apoyohimbine, 18 - hydroxy - apoyohimbine, 10 - hydroxy - 16 - carbomethoxy - 17 - methoxy - yohimbane, 10 - hydroxy - 3 - epi - apoyohimbine and 18 - hydroxy - 3 - epi - apoyohimbine.
GB3554156A 1956-11-21 1956-11-21 New alkaloid derivatives and methods of producing same Expired GB824496A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3554156A GB824496A (en) 1956-11-21 1956-11-21 New alkaloid derivatives and methods of producing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3554156A GB824496A (en) 1956-11-21 1956-11-21 New alkaloid derivatives and methods of producing same

Publications (1)

Publication Number Publication Date
GB824496A true GB824496A (en) 1959-12-02

Family

ID=10378884

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3554156A Expired GB824496A (en) 1956-11-21 1956-11-21 New alkaloid derivatives and methods of producing same

Country Status (1)

Country Link
GB (1) GB824496A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3120534A (en) * 1961-09-06 1964-02-04 Warner Lambert Pharmaceutical 10-methoxyyohimbane
US3395152A (en) * 1966-03-14 1968-07-30 Warner Lambert Pharmaceutical Preparation of d, 1-pseudoyohimbanes
FR2068400A1 (en) * 1969-10-09 1971-08-27 Roussel Uclaf

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3120534A (en) * 1961-09-06 1964-02-04 Warner Lambert Pharmaceutical 10-methoxyyohimbane
US3395152A (en) * 1966-03-14 1968-07-30 Warner Lambert Pharmaceutical Preparation of d, 1-pseudoyohimbanes
FR2068400A1 (en) * 1969-10-09 1971-08-27 Roussel Uclaf

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