GB820954A - Improvements in or relating to esters of 2,3-dimercaptopropanol - Google Patents
Improvements in or relating to esters of 2,3-dimercaptopropanolInfo
- Publication number
- GB820954A GB820954A GB1356956A GB1356956A GB820954A GB 820954 A GB820954 A GB 820954A GB 1356956 A GB1356956 A GB 1356956A GB 1356956 A GB1356956 A GB 1356956A GB 820954 A GB820954 A GB 820954A
- Authority
- GB
- United Kingdom
- Prior art keywords
- esters
- substituted
- acetate
- alcohol
- benzoate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
O-esters of 2:3-dimercapto propanol are prepared by a process wherein the alcohol is reacted by contacting, if necessary with heating, with a carboxylic acid halide of the general formula R.COX, wherein R is a substituted alkyl group or a substituted or unsubstituted aryl, aralkyl or cycloalkyl group, the substituents being such as are inert under the conditions of the reaction, and X is a halogen atom. The reaction is preferably effected with acid chlorides and in the presence of a liquid which is a solvent for the alcohol and the acid halide, especially a hydrocarbon solvent. Examples describe the preparation of the following O-esters of 2:3-mercapto propanol by refluxing the alcohol with the appropriate acid chloride in benzene with exclusion of moisture: (1) benzoate, (2) phenyl acetate, (3) o-chlorobenzoate, (4) p-chlorobenzoate, (5) p-methoxy benzoate, (6) hexahydrobenzoate, (7) b -methyl thiopropionate, (8) ethylthio acetate, (9) benzyl thio acetate, (10) 2:4-dichlorobenzoate, (11) a -naphthoate and (12) p-(p-toluene sulphonamido) benzoate. Certain of these esters have anti-tubercular activity. According to the Provisional Specification, the esters may be prepared from acid halides of the general formula R1COX, wherein R1 is a substituted, e.g. halo-substituted, or unsubstituted alkyl, aryl, aralkyl or cyclo-alkyl group and an additional example is given employing palmityl chloride as reagent. The esters, with the exception of the acetate, propionate, butyrate and the succinate, are stated to be new compounds. Specification 687,069 is referred to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1356956A GB820954A (en) | 1956-05-02 | 1956-05-02 | Improvements in or relating to esters of 2,3-dimercaptopropanol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1356956A GB820954A (en) | 1956-05-02 | 1956-05-02 | Improvements in or relating to esters of 2,3-dimercaptopropanol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB820954A true GB820954A (en) | 1959-09-30 |
Family
ID=10025337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1356956A Expired GB820954A (en) | 1956-05-02 | 1956-05-02 | Improvements in or relating to esters of 2,3-dimercaptopropanol |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB820954A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013503908A (en) * | 2009-09-04 | 2013-02-04 | ユナイテッド パラゴン アソシエイツ インコーポレイテッド | Compounds for treating disorders or diseases associated with neurokinin 2 receptor activity |
-
1956
- 1956-05-02 GB GB1356956A patent/GB820954A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013503908A (en) * | 2009-09-04 | 2013-02-04 | ユナイテッド パラゴン アソシエイツ インコーポレイテッド | Compounds for treating disorders or diseases associated with neurokinin 2 receptor activity |
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