ES285236A1 - Procedure for the preparation of penicillins (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of penicillins (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES285236A1
ES285236A1 ES285236A ES285236A ES285236A1 ES 285236 A1 ES285236 A1 ES 285236A1 ES 285236 A ES285236 A ES 285236A ES 285236 A ES285236 A ES 285236A ES 285236 A1 ES285236 A1 ES 285236A1
Authority
ES
Spain
Prior art keywords
penicillins
translation
procedure
preparation
machine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES285236A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Research Laboratories Ltd
Original Assignee
Beecham Research Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Research Laboratories Ltd filed Critical Beecham Research Laboratories Ltd
Publication of ES285236A1 publication Critical patent/ES285236A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms

Abstract

Procedure for the preparation of penicillins of the general formula: ** (See formula) ** and non-toxic salts thereof, wherein R is a hydrogen atom or an alkyl, aryl or aralkyl group, which may be substituted, which process comprises the reaction of a silyl derivative of 6-aminopenicillanic acid, of the general formula: ** (See formula) ** where R1, R2 and R3 are the same or different and each of them is an alkyl, aryl or aralkyl group, or a solution thereof, with a reactive derivative of a carboxylic acid of the general formula: ** (See formula) ** and subsequently the separation of the silyl groups by solvolysis. (Machine-translation by Google Translate, not legally binding)
ES285236A 1962-02-28 1963-02-18 Procedure for the preparation of penicillins (Machine-translation by Google Translate, not legally binding) Expired ES285236A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB775162A GB959853A (en) 1962-02-28 1962-02-28 Penicillins
GB775262 1962-02-28

Publications (1)

Publication Number Publication Date
ES285236A1 true ES285236A1 (en) 1963-06-01

Family

ID=26241643

Family Applications (1)

Application Number Title Priority Date Filing Date
ES285236A Expired ES285236A1 (en) 1962-02-28 1963-02-18 Procedure for the preparation of penicillins (Machine-translation by Google Translate, not legally binding)

Country Status (9)

Country Link
AT (1) AT275732B (en)
BR (1) BR6346795D0 (en)
CH (1) CH446336A (en)
DK (1) DK132412C (en)
ES (1) ES285236A1 (en)
FI (1) FI41652C (en)
GB (1) GB959853A (en)
NO (1) NO129956B (en)
SE (1) SE320369B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL37124A (en) * 1970-07-03 1974-10-22 Chinoin Gyogyszer Es Vegyeszet Chlorocarbonyl derivatives of penicillin and their preparation
US3678037A (en) * 1970-08-10 1972-07-18 American Home Prod Process for producing {60 -amino penicillin intermediates
US4182709A (en) * 1976-01-15 1980-01-08 Glaxo Group Limited Manufacture of semi-synthetic penicillin antibiotics
US4278600A (en) 1979-03-19 1981-07-14 Bristol-Myers Company Production of penicillins
US4310458A (en) 1979-03-19 1982-01-12 Bristol-Myers Company Production of penicillins
US7230097B2 (en) 2003-03-10 2007-06-12 Lupin Ltd. Process for preparation of 7-[α-Amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid

Also Published As

Publication number Publication date
BR6346795D0 (en) 1973-07-19
DK132412C (en) 1976-05-03
AT275732B (en) 1969-11-10
DK132412B (en) 1975-12-01
NO129956B (en) 1974-06-17
CH446336A (en) 1967-11-15
GB959853A (en) 1964-06-03
SE320369B (en) 1970-02-09
FI41652B (en) 1969-09-30
FI41652C (en) 1973-03-23

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