GB819852A - Improvements in or relating to new phenthiazine derivatives and processes for their preparation - Google Patents
Improvements in or relating to new phenthiazine derivatives and processes for their preparationInfo
- Publication number
- GB819852A GB819852A GB38910/57A GB3891057A GB819852A GB 819852 A GB819852 A GB 819852A GB 38910/57 A GB38910/57 A GB 38910/57A GB 3891057 A GB3891057 A GB 3891057A GB 819852 A GB819852 A GB 819852A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenthiazine
- cyano
- propyl
- piperazinyl
- dimaleate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- WJFKNYWRSNBZNX-UHFFFAOYSA-N 10H-phenothiazine Chemical class C1=CC=C2NC3=CC=CC=C3SC2=C1 WJFKNYWRSNBZNX-UHFFFAOYSA-N 0.000 title abstract 12
- -1 phenthiazine compound Chemical class 0.000 abstract 5
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 5
- 150000002148 esters Chemical class 0.000 abstract 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- JTTWNTXHFYNETH-UHFFFAOYSA-N propyl 4-methylbenzenesulfonate Chemical compound CCCOS(=O)(=O)C1=CC=C(C)C=C1 JTTWNTXHFYNETH-UHFFFAOYSA-N 0.000 abstract 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 2
- QFXXARKSLAKVRL-UHFFFAOYSA-N 2-(3-chloropropoxy)oxane Chemical compound ClCCCOC1CCCCO1 QFXXARKSLAKVRL-UHFFFAOYSA-N 0.000 abstract 1
- WFCSWCVEJLETKA-UHFFFAOYSA-N 2-piperazin-1-ylethanol Chemical compound OCCN1CCNCC1 WFCSWCVEJLETKA-UHFFFAOYSA-N 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- LAMUXTNQCICZQX-UHFFFAOYSA-N 3-chloropropan-1-ol Chemical compound OCCCCl LAMUXTNQCICZQX-UHFFFAOYSA-N 0.000 abstract 1
- QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 abstract 1
- YYROPELSRYBVMQ-UHFFFAOYSA-N 4-toluenesulfonyl chloride Chemical compound CC1=CC=C(S(Cl)(=O)=O)C=C1 YYROPELSRYBVMQ-UHFFFAOYSA-N 0.000 abstract 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- AGEZXYOZHKGVCM-UHFFFAOYSA-N benzyl bromide Chemical compound BrCC1=CC=CC=C1 AGEZXYOZHKGVCM-UHFFFAOYSA-N 0.000 abstract 1
- RDHPKYGYEGBMSE-UHFFFAOYSA-N bromoethane Chemical compound CCBr RDHPKYGYEGBMSE-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001860 citric acid derivatives Chemical class 0.000 abstract 1
- AFAXGSQYZLGZPG-UHFFFAOYSA-N ethanedisulfonic acid Chemical class OS(=O)(=O)CCS(O)(=O)=O AFAXGSQYZLGZPG-UHFFFAOYSA-N 0.000 abstract 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
- 150000002688 maleic acid derivatives Chemical class 0.000 abstract 1
- 150000002823 nitrates Chemical class 0.000 abstract 1
- 150000003891 oxalate salts Chemical class 0.000 abstract 1
- 235000021317 phosphate Nutrition 0.000 abstract 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 abstract 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 abstract 1
- 150000003892 tartrate salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
- C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
- C07D279/28—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom with other substituents attached to the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
- C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Chairs Characterized By Structure (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR728471 | 1956-12-27 | ||
| FR731471 | 1957-02-11 | ||
| FR731743 | 1957-02-14 | ||
| FR734099 | 1957-03-15 | ||
| FR737286 | 1957-04-26 | ||
| FR743682 | 1957-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB819852A true GB819852A (en) | 1959-09-09 |
Family
ID=27546128
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB38910/57A Expired GB819852A (en) | 1956-12-27 | 1957-12-13 | Improvements in or relating to new phenthiazine derivatives and processes for their preparation |
| GB1046/58A Expired GB819886A (en) | 1956-12-27 | 1958-01-10 | New phenthiazine derivatives and processes for their preparation |
| GB2555/58A Expired GB824536A (en) | 1956-12-27 | 1958-01-24 | Improvements in or relating to new phenthiazine derivatives and processes for their preparation |
| GB14506/58A Expired GB824548A (en) | 1956-12-27 | 1958-05-06 | Improvements in or relating to collapsible chairs |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1046/58A Expired GB819886A (en) | 1956-12-27 | 1958-01-10 | New phenthiazine derivatives and processes for their preparation |
| GB2555/58A Expired GB824536A (en) | 1956-12-27 | 1958-01-24 | Improvements in or relating to new phenthiazine derivatives and processes for their preparation |
| GB14506/58A Expired GB824548A (en) | 1956-12-27 | 1958-05-06 | Improvements in or relating to collapsible chairs |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US2975175A (enExample) |
| BE (4) | BE563461A (enExample) |
| CH (2) | CH374674A (enExample) |
| DE (2) | DE1097996B (enExample) |
| FR (7) | FR1186175A (enExample) |
| GB (4) | GB819852A (enExample) |
| LU (3) | LU35590A1 (enExample) |
| NL (4) | NL103867C (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL258900A (enExample) * | 1959-12-11 | |||
| NL120362C (enExample) * | 1961-04-26 | |||
| US3285919A (en) * | 1961-05-10 | 1966-11-15 | Sahyun Melville | Piperazinyl alkyl thiaxanthene derivatives |
| IT8453617U1 (it) * | 1984-07-06 | 1986-01-06 | Surace Spa | Carrozzella per infermi pieghevole a telaio di sostegno ad X e permettente un leggero disassamento fra telaio e ossatura della stessa |
| CH678486C1 (enExample) * | 1988-06-18 | 2000-11-30 | Rainer Küschall | |
| US9695138B1 (en) * | 2016-10-17 | 2017-07-04 | Acenda Pharma, Inc. | Phenothiazine derivatives and methods of use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2534237A (en) * | 1950-12-19 | B-haloxanthine salts of aminoalkyl | ||
| US2650919A (en) * | 1953-09-01 | Basic esters of phenothiazine-io-car | ||
| US2272498A (en) * | 1939-02-04 | 1942-02-10 | Gen Aniline & Film Corp | Process for producing compounds of the diaryl series |
| NL97951C (enExample) * | 1955-11-15 | |||
| US2889328A (en) * | 1956-01-19 | 1959-06-02 | Schering Corp | N (2 substituted thio phenyl) n phenyl, alkylene diamines |
| BE558008A (enExample) * | 1956-06-21 |
-
1956
- 1956-12-27 FR FR1186175D patent/FR1186175A/fr not_active Expired
-
1957
- 1957-01-31 FR FR1186186D patent/FR1186186A/fr not_active Expired
- 1957-02-11 FR FR1166240D patent/FR1166240A/fr not_active Expired
- 1957-02-14 FR FR1189122D patent/FR1189122A/fr not_active Expired
- 1957-03-15 FR FR71701D patent/FR71701E/fr not_active Expired
- 1957-04-26 FR FR71703D patent/FR71703E/fr not_active Expired
- 1957-07-19 FR FR71869D patent/FR71869E/fr not_active Expired
- 1957-11-22 LU LU35590D patent/LU35590A1/xx unknown
- 1957-12-04 LU LU35612D patent/LU35612A1/xx unknown
- 1957-12-05 LU LU35615D patent/LU35615A1/xx unknown
- 1957-12-11 CH CH5365057A patent/CH374674A/fr unknown
- 1957-12-13 GB GB38910/57A patent/GB819852A/en not_active Expired
- 1957-12-17 DE DES56300A patent/DE1097996B/de active Pending
- 1957-12-20 US US704011A patent/US2975175A/en not_active Expired - Lifetime
- 1957-12-23 BE BE563461D patent/BE563461A/xx unknown
- 1957-12-24 NL NL223587A patent/NL103867C/xx active
-
1958
- 1958-01-09 DE DE1958S0056519 patent/DE1075621B/de active Pending
- 1958-01-10 GB GB1046/58A patent/GB819886A/en not_active Expired
- 1958-01-17 NL NL224148A patent/NL101630C/xx active
- 1958-01-20 NL NL224190A patent/NL103590C/xx active
- 1958-01-24 GB GB2555/58A patent/GB824536A/en not_active Expired
- 1958-01-28 CH CH5518258A patent/CH380134A/fr unknown
- 1958-01-28 BE BE564321D patent/BE564321A/xx unknown
- 1958-02-05 BE BE564557D patent/BE564557A/xx unknown
- 1958-02-10 BE BE564673D patent/BE564673A/xx unknown
- 1958-02-13 NL NL224888A patent/NL102466C/xx active
- 1958-05-06 GB GB14506/58A patent/GB824548A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE563461A (enExample) | 1958-06-23 |
| BE564557A (enExample) | 1958-08-05 |
| LU35615A1 (enExample) | 1958-02-05 |
| NL102466C (enExample) | 1962-09-17 |
| FR1186186A (fr) | 1959-08-17 |
| BE564321A (enExample) | 1958-07-28 |
| LU35590A1 (enExample) | 1958-01-22 |
| CH374674A (fr) | 1964-01-31 |
| FR71701E (enExample) | 1960-01-19 |
| DE1075621B (de) | 1960-02-18 |
| NL103867C (enExample) | 1963-02-15 |
| FR1186175A (fr) | 1959-08-17 |
| FR1166240A (fr) | 1958-11-04 |
| FR71869E (fr) | 1960-02-01 |
| US2975175A (en) | 1961-03-14 |
| NL103590C (enExample) | 1963-01-15 |
| FR71703E (enExample) | 1960-01-19 |
| CH380134A (fr) | 1964-07-31 |
| FR1189122A (fr) | 1959-09-29 |
| BE564673A (enExample) | 1958-08-11 |
| NL101630C (enExample) | 1962-06-15 |
| GB819886A (en) | 1959-09-09 |
| GB824548A (en) | 1959-12-02 |
| LU35612A1 (enExample) | 1958-02-04 |
| DE1097996B (de) | 1961-01-26 |
| GB824536A (en) | 1959-12-02 |
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