US2889328A - N (2 substituted thio phenyl) n phenyl, alkylene diamines - Google Patents

N (2 substituted thio phenyl) n phenyl, alkylene diamines Download PDF

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US2889328A
US2889328A US560083A US56008356A US2889328A US 2889328 A US2889328 A US 2889328A US 560083 A US560083 A US 560083A US 56008356 A US56008356 A US 56008356A US 2889328 A US2889328 A US 2889328A
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methylthio
acid
phenyl
ether
chlorodiphenylamine
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Sherlock Margaret
Sperber Nathan
Papa Domenick
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Merck Sharp and Dohme Corp
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Definitions

  • R Similarly falling within the definition of R are lower alkyls such as methyl, ethyl, butyl; aralkyl groupings such as benzyl and aryl groups such as phenyl which may or may not be substituted.
  • R is piperaZ-ino, we include within our invention such radicals as 4-alkylpiperazino, 4-hydroxyalkylpiperazino and 4-oxyalkoxyalkylpiperazino.
  • the compounds of the general formula possess certain important physiological properties which are useful in chemopsychotherapeutic applications. These compounds manifest themselves by exerting a calming and a quieting effect, thereby lending themselves to application to neuropsychiatric patients in particular. Thus, in their ability to tranquilize severely disturbed patients such as those in mental institutions, the restlessness and hyperactivity of the patient are relieved, permitting an improvement in appetite and sleeping habits. Furthermore, along with their general tranquilizing properties, these compounds are useful in allaying anxiety and tension which arise from a myriad of sources such as gynecologic disorders, dermatologic conditions, etc.
  • the compounds of our invention may be administered as anti-emetics in the treatment of nausea and vomiting.
  • the mechanism by which this action occurs is not completely known, but we believe that the compounds exert a depressant effect on the central nervous system and on the medulla, thus inhibiting the vomiting center and preventing or stopping emesis.
  • compounds of the generalformula are insoluble in aqueous media, they are preferably administered in the form of a soluble non-toxic acid addition salt such as hydrochloride, maleate, tartrate,
  • the preferred mode of administration is oral by means of tablets or elixirs in conjunction with suitable carriers and other types of pharmaceutical dosage units which lend themselves to such administration.
  • the compound in the form of non-toxic acid addition salt is prepared in sterile solutions or suspensions.
  • compounds of our invention may be administered in doses ranging from 10 to mg. per day, although doses as high as 250 mg. may be used in severe cases.
  • the compounds of our invention may be prepared by alkylation of an o-methylthiodiphenylamine with a substituted alkyl halide such as dimethylaminopropyl chloride, piperidinoethyl chloride and the like.
  • a substituted alkyl halide such as dimethylaminopropyl chloride, piperidinoethyl chloride and the like.
  • reaction sequence may be applied generally for the preparation of thiodiphenylamines which possess a substituent in either or both rings.
  • thiodiphenylamines which possess a substituent in either or both rings.
  • the substituent such as chloro
  • the substituent may be present in the starting thioaniline as is exemplified by 2- methylthio-S-chloroaniline (which is obtained by methylation of the corresponding benzenethiol with dimethylsulfate).
  • the ultimate product obtained with this intermediate is Z-methylthio-S-chlorodiphenylamine.
  • the alkylation of the diphenylamine maybe carried out in a variety of Ways in addition to the well-known utilization of a dialkylaminoalkyl halide in the presence ther reacted with a secondary amine such as dimethyl-' amine, pyrrolidine, piperidine, piperazine, morpholine and the'like, giving rise to compounds having the configura Patented June 2, 1959' tion shown in general Formula I.
  • a secondary amine such as dimethyl-' amine, pyrrolidine, piperidine, piperazine, morpholine and the'like, giving rise to compounds having the configura Patented June 2, 1959' tion shown in general Formula I.
  • Salts of the free base of our invention may be prepared by methods described in the literature. For example, bubbling anhydrous hydrogen chloride into an ether solution of the free base causes.
  • salts such as the maleate are prepared by mixing equal molecular quantities of the free base and the carboxylic acid in a solvent such as ethyl acetate or isopropyl acetate and forcing crystallization either by concentration or dilution with a second solvent in which the salt is insoluble.
  • N- ('y-dimethylaminopropyl) -2-me thylthiodiphenylamine The requisite intermediate, N-(o-methylthiophenyl)- anthranilic acid is prepared in the following manner: A mixture of 42.8 g. of o-methylthioaniline, 62 g. of potassium o-chlorobenzoate and 3'. g. of copper powder in 150 ml. ofn -amyl alcohol is stirred and heated at reflux for six hours. The reaction mixture is made alkaline with sodium bicarbonate solution and steam distilled to remove the amyl alcohol. The residue is cooled and thoroughly extracted with ether.
  • the basic aqueous layer is acidified with dilute acetic acid and the precipitate so formed is removed by filtration. Recrystallization from benzene yields N-(o-methylthiophenyl)-anthranilic acid, M.P. 184-185.
  • Decauboxylation of the anthranilic acid obtained above is. eflected by heating 32.5 g. of the acid at 240-260 for one to two hours. Theresidual oil is distilled affording Z-methylthiodiphenylamiflc, B.P. 151-155 /0.5 mm.
  • sodamide from 1.88 g. of sodium
  • sodamide from 1.88 g. of sodium
  • liquid ammonia 300 ml. of liquid ammonia
  • 9.8 g. of -dimethylaminopropyl chloride is added, followed by the slow addition of 200 ml. of anhydrous toluene.
  • the ammonia is allowed to evaporate and the reaction mixture isrefluxed and stirred for eight hours.
  • the mixture isdecomposed with water and the toluene layer extracted with dilute hydrochloric acid.
  • the aqueous layer is made alkaline with 50 sodium hydroxide solution and the oily layer which separates is extracted with ether.
  • the following alkylation procedure may be employed: To a. suspension of sodamide (from 2.3 g. of sodium) and 300 ml. of liquid ammonia ether is added 21.5 g. of o-methylthiodiphenylamine. After stirring for 30 minutes, 16 g. of l-chloro-3-bromopropane is added dropwise. When the ammonia has evaporated, 200ml. of water is added and the separated oil is extracted with ether. The ether extracts are dried over anhydrous sodium sulfate and concentrated. The crude. residue, N-(yhlq crmpy -m th t i0d pheny miu -is hea ed. n a,
  • EXAM L 2 N- (y-dimethylaminopropyl)-2-methylthiodiplzenylamine monohydrochloride A solution of 1 g. of the free base obtained in Example 1 in 3 ml. of anhydrous ethanol is treated with 5 ml. of a saturated solution of hydrogen chloride in anhydrous ethanol. Upon cooling, the hydrochloride of this example is obtained and is purified by recrystallization from ethanol, M.P. 205-207".
  • N-dim ethylaminopr0pyl -2-methylthi0-3 chlorodiphenylamine The requisite intermediate, N-(o-methylthiophenyl)-4- chloroanthranilic acid is prepared from the reaction of 32.9 g. of o-methylthioaniline, 55.9 g. of the potassium salt of 2,4dichlorobenzoic acid, 2.3 g. of copper powder and ml. of n-amyl alcohol according to the procedure in Example 1.
  • the acid isobtained as yellow crystals, M.P. 212-214", after recrystallization from ethyl acetate.
  • a hydrochloride prepared as described in Example 2 melts at 176.-177.
  • N-(fl-diethylaminoethyl) -2-methylthiodiphenylamine By the alkylation of 17.3 g. of Z-methylthiodiphenylamine with sodamide (from 1.88 g. of sodium) and 11 g. of ,B-diethylaminoethyl chloride in the manner described in Example 1, there is obtained N-(fi-diethylaminoethyl) -2-methylthiodiphenylamine, B.P. 171-172 1.0 mm.” 4
  • N-(2-benzylthio-5-bromophenyl)anthranilic acid so obtained is decarboxylated by heating at 240260 for EXAMPLE 9 N- (p-pyrrolidin'oethyl)-2-methy'lzfhio-4-melhoxydiphenyl amine
  • a solution of 31 g. of 2-amino-5-methoxythiophenol in 50 ml. of water containing 8 g. of sodium hydroxide is treated with 26 g. of dimethyl sulfate as in Example 4, yielding 2-rnethylthio-4-methoxyaniline as a light yel low oil; B.P. 130132/6.0 mm.
  • the requisite intermediate N-(o-methylthiophenyl)-4- methylanthranilic acid is prepared from the reaction of 32.9 g. of o-methylthioaniline, 51 g. of the potassium salt of 2-chloro-4-methylbenzoic acid and 2.3 g. of copper powder according to the procedure in Example 1.
  • the crude acid thus obtained is decarboxylated at 240-260 for three hours and distillation of the residue yields a yellow oil, 2-methylthio-3-methyldiphenylamine, B.P. 142145/1.0 mm.
  • a mixture of 25 g. of 4-(B-hydroxyethyl)-piperazine and 16 g. of the crude N-(y-chloropropyl) -2-methylthio- 3-chlorodiphenylamine obtained above is heated for 18 hours on a steam bath.
  • the mixture is decomposed by the addition of 200 ml. of water and the aqueous mixture is extracted several times with ether.
  • the ether layer is then extracted with dilute hydrochloric acid.
  • the acid layer is basified with sodium hydroxide solution and the resulting oil is extracted with ether.
  • the ether extracts are dried, concentrated and the residue distilled, yielding the product of this example, an oil haying a 31?. of 255-260 (1.0 mm.).
  • R is a member of the group consisting of H, halogen, lower alkyl and lower alkyloxy; R is selected from the group consisting of H, lower aliphatic alkyl, phenyl and benzyl; R is an amino group selected from. the class consisting of lower dialkylamino, pyrrolidino, piperidino, morpholino, and piperazino and n is an integer from 2 to 4.
  • N r g H with an aminoalkyl halide of the formula:

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Description

N (2 SUBSTITUTED THIO PHENYL) N PHENYL, ALKYLENE DIAMINES Margaret Sherlock and Nathan Sperber, Bloomfield, and Domenick Papa, Glen Ridge, N.J., assignors to Schering Corporation, Bloomfield, N.J., a corporation of New Jersey 7 No Drawing. Application January 19, 1956 Serial No. 560,083
17 Claims. (Cl. 260-268) SR v ( r-Rl wherein R is a member of the group consisting of H, halogen, lower alkyloxy or lower alkyl, R, is a member of the group consisting of H, lower alkyl, aralkyl or aryl, R is a member of the group consisting of lower dialkylamino, pyrrolidino, piperidine, morpholino, and piperazino, and n is an integer from 2 to 4. Representative members of the moieties included in the definition of R are exemplified by chlorine, bromine, iodine, methoxy, ethoxy, methyl, ethyl and the like. Similarly falling within the definition of R are lower alkyls such as methyl, ethyl, butyl; aralkyl groupings such as benzyl and aryl groups such as phenyl which may or may not be substituted. Where R is piperaZ-ino, we include within our invention such radicals as 4-alkylpiperazino, 4-hydroxyalkylpiperazino and 4-oxyalkoxyalkylpiperazino. Specific examples of the foregoing are 4-methylpiperazino, 4-ethylpiperazino, 4-(fi-hydroxyethyl)-piperazino, 4-[19- (B' hydroxyethoxy) -ethyl] -piperazino, 4- [/3- (fl-ethoxy ethoxy) -ethyl]-piperazino and the like. 1
We have found that the compounds of the general formula possess certain important physiological properties which are useful in chemopsychotherapeutic applications. These compounds manifest themselves by exerting a calming and a quieting effect, thereby lending themselves to application to neuropsychiatric patients in particular. Thus, in their ability to tranquilize severely disturbed patients such as those in mental institutions, the restlessness and hyperactivity of the patient are relieved, permitting an improvement in appetite and sleeping habits. Furthermore, along with their general tranquilizing properties, these compounds are useful in allaying anxiety and tension which arise from a myriad of sources such as gynecologic disorders, dermatologic conditions, etc.
In addition, the compounds of our invention may be administered as anti-emetics in the treatment of nausea and vomiting. The mechanism by which this action occurs is not completely known, but we believe that the compounds exert a depressant effect on the central nervous system and on the medulla, thus inhibiting the vomiting center and preventing or stopping emesis.
In addition to the important applications of the compounds cited above, our new substances exhibit antiited States Patent citrate and the like.
Since for the most part, compounds of the generalformula are insoluble in aqueous media, they are preferably administered in the form of a soluble non-toxic acid addition salt such as hydrochloride, maleate, tartrate,
The preferred mode of administration is oral by means of tablets or elixirs in conjunction with suitable carriers and other types of pharmaceutical dosage units which lend themselves to such administration. In certain instances where parenteral administration is indicated, the compound in the form of non-toxic acid addition salt is prepared in sterile solutions or suspensions.
Depending upon the treatment and the indication, the
compounds of our invention may be administered in doses ranging from 10 to mg. per day, although doses as high as 250 mg. may be used in severe cases.
The compounds of our invention may be prepared by alkylation of an o-methylthiodiphenylamine with a substituted alkyl halide such as dimethylaminopropyl chloride, piperidinoethyl chloride and the like. We prefer to prepare the o-alkylthiodiphenylamines according to the following sequence of reactions:
heat;
@HSO N H In the foregoing reaction scheme a thioaniline such as o-methylthioaniline (II) is reacted with an o-halogenated benzoic acid salt such as potassium o-chlorobenzoate (III) in the presence of copper powder. The carboxydiphenylamine (IV) is easily decarboxylated by heating, thereby generating the alkylthiodiphenylamine, V. Alklation of V as indicated with dimethylaminoethyl chloride in the presence of sodamide gives rise to a compound falling within the general Formula I.
The foregoing reaction sequence may be applied generally for the preparation of thiodiphenylamines which possess a substituent in either or both rings. For example, in place of III, there may be used a salt of 2,4- dichlorobenzoic acid, ultimately yielding after decarboxylation o-methylthio-m'-chlorodiphenylamine.
Alternatively, the substituent, such as chloro, may be present in the starting thioaniline as is exemplified by 2- methylthio-S-chloroaniline (which is obtained by methylation of the corresponding benzenethiol with dimethylsulfate). The ultimate product obtained with this intermediate is Z-methylthio-S-chlorodiphenylamine.
The alkylation of the diphenylamine maybe carried out in a variety of Ways in addition to the well-known utilization of a dialkylaminoalkyl halide in the presence ther reacted with a secondary amine such as dimethyl-' amine, pyrrolidine, piperidine, piperazine, morpholine and the'like, giving rise to compounds having the configura Patented June 2, 1959' tion shown in general Formula I. For clarification, this I alternative method of' alkylation by a two step process VII Salts of the free base of our invention may be prepared by methods described in the literature. For example, bubbling anhydrous hydrogen chloride into an ether solution of the free base causes. immediate precipitation of the corresponding hydrochloride which may be recrystallized from alcohobeth'er mixtures. Other salts such as the maleate are prepared by mixing equal molecular quantities of the free base and the carboxylic acid in a solvent such as ethyl acetate or isopropyl acetate and forcing crystallization either by concentration or dilution with a second solvent in which the salt is insoluble.
EXAMPLE 1 N- ('y-dimethylaminopropyl) -2-me thylthiodiphenylamine The requisite intermediate, N-(o-methylthiophenyl)- anthranilic acid is prepared in the following manner: A mixture of 42.8 g. of o-methylthioaniline, 62 g. of potassium o-chlorobenzoate and 3'. g. of copper powder in 150 ml. ofn -amyl alcohol is stirred and heated at reflux for six hours. The reaction mixture is made alkaline with sodium bicarbonate solution and steam distilled to remove the amyl alcohol. The residue is cooled and thoroughly extracted with ether. The basic aqueous layer is acidified with dilute acetic acid and the precipitate so formed is removed by filtration. Recrystallization from benzene yields N-(o-methylthiophenyl)-anthranilic acid, M.P. 184-185.
Decauboxylation of the anthranilic acid obtained above is. eflected by heating 32.5 g. of the acid at 240-260 for one to two hours. Theresidual oil is distilled affording Z-methylthiodiphenylamiflc, B.P. 151-155 /0.5 mm.
To a suspension of sodamide (from 1.88 g. of sodium) in 300 ml. of liquid ammonia, there isv added 17.3 g. of, Z-methylthiodiphenylamin'e. After stirring for twenty minutes, 9.8, g. of -dimethylaminopropyl chloride is added, followed by the slow addition of 200 ml. of anhydrous toluene. The ammonia is allowed to evaporate and the reaction mixture isrefluxed and stirred for eight hours. The mixture isdecomposed with water and the toluene layer extracted with dilute hydrochloric acid. The aqueous layer is made alkaline with 50 sodium hydroxide solution and the oily layer which separates is extracted with ether. The ether extracts are dried over anhydrous sodium sulfate, concentrated and the residual oil distilled yielding N-(q/ dimethylaminopropyl) 2- methylthiodiphenylamine, B.P. 184-185 (0.5 mm.).
Alternatively, the following alkylation procedure may be employed: To a. suspension of sodamide (from 2.3 g. of sodium) and 300 ml. of liquid ammonia ether is added 21.5 g. of o-methylthiodiphenylamine. After stirring for 30 minutes, 16 g. of l-chloro-3-bromopropane is added dropwise. When the ammonia has evaporated, 200ml. of water is added and the separated oil is extracted with ether. The ether extracts are dried over anhydrous sodium sulfate and concentrated. The crude. residue, N-(yhlq crmpy -m th t i0d pheny miu -is hea ed. n a,
4 sealed tube with an excess of dimethylamine at -120 for 4-6 hours. The crude reaction mixture is treated with dilute hydrochloric acid solution and extracted with ether. The acid layer is basified with sodium hydroxide solution and the resulting oil is extracted with ether. The ether extracts are dried, concentrated and the residue fractionally distilled, yielding the compound of this example.
EXAM L 2 N- (y-dimethylaminopropyl)-2-methylthiodiplzenylamine monohydrochloride A solution of 1 g. of the free base obtained in Example 1 in 3 ml. of anhydrous ethanol is treated with 5 ml. of a saturated solution of hydrogen chloride in anhydrous ethanol. Upon cooling, the hydrochloride of this example is obtained and is purified by recrystallization from ethanol, M.P. 205-207".
EXAMPLE 3 N -dim ethylaminopr0pyl -2-methylthi0-3 chlorodiphenylamine The requisite intermediate, N-(o-methylthiophenyl)-4- chloroanthranilic acid is prepared from the reaction of 32.9 g. of o-methylthioaniline, 55.9 g. of the potassium salt of 2,4dichlorobenzoic acid, 2.3 g. of copper powder and ml. of n-amyl alcohol according to the procedure in Example 1. The acid isobtained as yellow crystals, M.P. 212-214", after recrystallization from ethyl acetate.
Decarboxylation of 28 g. of N-(o-methylthiophenyD- 4-chloroanthranilic acid at 240-260" for three and onehalf hours and distillation of the residue yields a yellow oil, 2-methylthio-3-chlorodiphenylamine, Bl. 146-148 (0 mm.
By the method of Example 1, 13.0 g. of 2-methylthio- 3-chlorodiphenylarnine is alkylated with sodamide (from 1.27 g. of sodium.) and 8 g. of 'y-dimethylaminopropyl chloride yielding N-(y-dimethylaminopropyl)-2-methylchic-3-chlorodiphenylamine, B1. 202204/0.5 mm.
A hydrochloride prepared as described in Example 2 melts at 176.-177.
When a solution of the free base in anhydrous ether is treated with gaseous methyl bromide for three hours, N ('y dimethylaminopropyl) 2 methylthio 3- chlorodiphenylamine methyl bromide is obtained. The white, crystallinequaternary is recrystallized from absolute ethanol, M.P. 182-183.
EXAMPLE 4 N-(y-pyrrolidirwpropyl)-2-methylthioJ-ehlorodiphenylamina The requisite intermediate, Z-methylthio-S-chloroaniline is prepared as follows: To a solution of 63.8 g. of 4-chloro-Z-aminothiophenol in 100 ml. of water containing 16 g. of sodium hydroxide there is added over a period of one hour, 52 g. of dimethylsulfate, keeping the reaction temperature below 50. After stirring for one hour, the reaction mixture is made alkaline with 10% sodium hydroxide and extracted with ether. The ether extracts are dried over anhydrous sodium sulfate, concentrated. and the residual oil is distilled, yielding the thiochloroaniline, B.P. l24126/ 8.0 mm.
A mixture of 26.5 g. of 2-methylthio-5-chloroaniline, 31 g. of the potassium salt of o-chlorobenzoic acid and 1.5 g. of copper powder is reacted as in Example 1. The crude acid, Z-methylthio-5-chloro-2-carboxydiphenylamine is obtained as a pale yellow powder.
Decarboxylation of the crude 2-methylthio-5-chloro- 2'-carboxydiphenylamine at 240260 as in Example 1 affords Z-methylthio-S-chlorodiphenylamine as a yellow oil, B.P. -l54/1.0 mm.
Alkylation of 20 g, of 2-methylthio-5-chlorodiphenyl- W h. dtc (from: 1- 8 sq u), d. 12
gZ 'of 'y-pyrrolidinopropylchloride as in Example 1 yields N (7 pyrrolidinopropyl) 1 2 methylthio 5 chlorodiphenylamine as a viscous yellow oil, B.P. 218-222/ 0.5 mm.
EXAMPLE 5 N-(fl-diethylaminoethyl) -2-methylthiodiphenylamine By the alkylation of 17.3 g. of Z-methylthiodiphenylamine with sodamide (from 1.88 g. of sodium) and 11 g. of ,B-diethylaminoethyl chloride in the manner described in Example 1, there is obtained N-(fi-diethylaminoethyl) -2-methylthiodiphenylamine, B.P. 171-172 1.0 mm." 4
EXAMPLE 6 N-( y-piperz'dinopropyl) -2-methylthi0-3'-chl0r0a'iphenylamine By the alkylation of 26 g. of 2-rnethylthio-3'-chlorodiphenylarnine with sodamide (from 2.5 g. of sodium) and 225g; of 'piperidinopropyl Chloride yields the compound of this example as a viscous yellow oil, B.P. 240242/0.5 mm.
EXAMPLE 7 N -(fi-dimethylaminopropyl) -2-methylthi0-5-chl0rodiphenylamine By the alkylation of 20 g. of Z-methylthio-S-chlorodiphenylamine with 9.8 g. of fi-dimethylaminopropyl chloride in the presence of sodamide prepared from 2.1 g. of sodium as in Example 1. There is obtained N 8- dimethylaminopropyl) 2 methylthio 5 chlorodiphenylamine as a viscous yellow oil, B.P. 207212/ 1.0 mm.
EXAMPLE 8 N- ('y-dipropylaminopropyl) -2-benzylfhi0-5-br0m0diphenylamine The intermediate, Z-benzylthio-5-bromodiphenylamine is prepared as follows: A mixture of 30 g. of Z-benzylthio-S-bromoaniline, 21 g. of the potassium salt of o-chlorobenzoic acid and 1 g. of copper powder are refluxed in 100 ml. of n-amyl alcohol as in Example 1. The crude N-(2-benzylthio-5-bromophenyl)anthranilic acid so obtained is decarboxylated by heating at 240260 for EXAMPLE 9 N- (p-pyrrolidin'oethyl)-2-methy'lzfhio-4-melhoxydiphenyl amine A solution of 31 g. of 2-amino-5-methoxythiophenol in 50 ml. of water containing 8 g. of sodium hydroxide is treated with 26 g. of dimethyl sulfate as in Example 4, yielding 2-rnethylthio-4-methoxyaniline as a light yel low oil; B.P. 130132/6.0 mm.
A mixture of 26 g. of Z-methylthio-4-methoxyaniline, 31 g. of the potassium salt of o-chlorobenzoic acid and 1.5 g. of copper powder is reacted and worked up as in Example 1. Decarboxylation of the crude N-(2- methylthio-4-methoxyphenyl)anthranilic acid so obtained yields Z-methylthio-4-methoxydiphenylamine; B.P. 150- 153/0.05 mm.
The alkylation of 19.5 g. of 2-rnethylthio-4-methoxydiphenylamine with sodamide (from 1.88 g. of sodium) and 11 g. of fi-pyrrolidinoethyl chloride as in Example 1 afiords N-(fi-pyrrolidinoethyl)-2-methylthio-4-methoxydiphenylamine; B.P. 195-198/0.5 mm.
EXAMPLE 10 v r N -(A-dimethylamin0butyl) -2-phenylthiodiphenylamine From 31 g. of Z-phenylthioaniline, 31 g. of the potassium salt of o-chlorobenzoic acid and 1.5 g. of copper powder as in Example 1 affords crude N-(2-phenylthiophenyl) anthranilic acid which is decarboxylated yielding 2-phenylthiodiphenylamine, B.P. 165-168/ 0.05 mm.
Alkylation of 22 g. of Z-phenylthiodiphenylamine with sodamide (from 1.88 g. of sodium) and 11 g. of A- dimethylaminobutyl chloride as previously described yields N (A-dimethylaminobutyl)-2-phenylthiodiphenylamine; B.P. 207-210/ 1.0 mm.
EXAMPLE 11 N 'y-dimethylamlinopropyl -2-mercapt0diphenylamine To a solution of 15 g. of N-(y-dimethylaminopropyh- 2-methylthiodiphenylamine in 200 ml. of liquid ammonia is added 2.5 g. of freshly cut sodium. After the ammonia has evaporated, water is added cautiously. The mixture is made strongly alkaline with sodium hydroxide, in the cold, and extracted with ether. The aqueous alkaline layer is neutralized with acetic acid, the separated oil is extracted with ether. The ether extracts are concentrated under an atmosphere of nitrogen. The residual oil is distilled in vacuo in an atmosphere of nitrogen yielding the mercapto intermediate, B.P. 178-180/ 0.05 mm.
EXAMPLE 12 N -('y-dimethylaminopropyl) -2-methylthi03'-methyl diphenylamzne Y The requisite intermediate N-(o-methylthiophenyl)-4- methylanthranilic acid is prepared from the reaction of 32.9 g. of o-methylthioaniline, 51 g. of the potassium salt of 2-chloro-4-methylbenzoic acid and 2.3 g. of copper powder according to the procedure in Example 1. The crude acid thus obtained is decarboxylated at 240-260 for three hours and distillation of the residue yields a yellow oil, 2-methylthio-3-methyldiphenylamine, B.P. 142145/1.0 mm.
By the method of Example 1, 12.0 g. of 2-methylthio- 3'-methyldiphenylamine is alkylated with 'sodamide (from 1.27 g. of sodium) and 8 g. of y-dimethylaminopropyl 1 chloride yielding N-(y-dimethylaminopropyl)-2-methy1- thio-3'-methyldiphenylamine, B. P. 198201/1.0 mm.
When a solution of 3.14 g. of the free base in 25 ml.
ethyl acetate is treated with a hot solution of 1.2 g. of
maleic acid in 25 ml. of ethyl acetate, a quantitative yield of the maleate is obtained which is purified by recrystallization from ethyl acetate.
EXAMPLE 13 N-'y [4-(fl-hydroxyethyl) -pip'erazino] -propyl-2-inethylthi0-3'-chl0rodiphenylamine To a suspension of sodamide (from 3 g. of sodium) in 300 ml. of liquid ammonia, there is added 31 g. of 2- methylthio-3-chlorodiphenylamine. After stirring for one hour, 19 g. of 1-bromo-3-chloropropane is added. The ammonia is allowed to evaporate and to the residue there is then added 200 ml. of water. The oily layer which separates is extracted with ether. The ether extracts are dried over anhydrous sodium sulfate, filtered and concentrated. N-(y-chloropropyl)-2-methylthio-3'- chlorodiphenylamine is obtained in the form of a crude oil.
A mixture of 25 g. of 4-(B-hydroxyethyl)-piperazine and 16 g. of the crude N-(y-chloropropyl) -2-methylthio- 3-chlorodiphenylamine obtained above is heated for 18 hours on a steam bath. The mixture is decomposed by the addition of 200 ml. of water and the aqueous mixture is extracted several times with ether. The ether layer is then extracted with dilute hydrochloric acid. The acid layer is basified with sodium hydroxide solution and the resulting oil is extracted with ether. The ether extracts are dried, concentrated and the residue distilled, yielding the product of this example, an oil haying a 31?. of 255-260 (1.0 mm.).
We claim:
1. Com-pounds selected from the group consisting of the free bases of the following formula and the non-toxic acid addition salts thereof:
D -Rn wherein R is a member of the group consisting of H, halogen, lower alkyl and lower alkyloxy; R is selected from the group consisting of H, lower aliphatic alkyl, phenyl and benzyl; R is an amino group selected from. the class consisting of lower dialkylamino, pyrrolidino, piperidino, morpholino, and piperazino and n is an integer from 2 to 4.
2. N- -dirnethylan inopropyl)-2-methylthio-3'-chlorodiphenylamine.
3. N-(q-pyrrolidinopropyl)-2-methyltl1io 5 chlorodiphenylamine.
4. N-(B diethylaminoethyl) 2 methylthiodiphenylamine.
5. N-(fi dimethylaminopropyl) -2-methylthio-S-chlorodiphenylamine.
6. N-( y dipropylaminopropyl),-2-benzylthio-5-bromodiphenylamine.
7. A process for the manufacture of a compound of the formula:
, N r g H with an aminoalkyl halide of the formula:
R (CH ),,Hal and recovering the resulting condensation product.
8- q s o d n to c a m 7 here the oadsnse i u is carried out in the presence of a basic condensipgagent:
9. Process for preparing compounds of; claim 1 which comprises condensing a diphenylamine of the formula:
SR R R with a dihalohydrocarbon of the formula:
Cl(CH ),,Br isolating the N-alkylated diphenylamine of the formula;
(011,)..01 and condensing the latter with a secondary amine of the formula:
References Cited in the file of this patent UNITED STATES PATENTS 2,642,433 Duschinsky June 16,1953; 2,745,837 Papa May 15,1956
FOREIGN PATENTS 550,327 Germany Oct. 24, 1930 OTHER REFERENCES.
King et al.: Journal of the Chemical Society (London) for 1946, pp. 5-10.

Claims (2)

1. COMPOUNDS SELECTED FROM THE GROUP CONSISTING OF THE FREE BASES OF THE FOLLOWING FORMULA AND THE NON-TOXIC ACID ADDITION SALTS THEREOF:
4. N-(B-DIETHYLAMINOETHYL)-2- METHYLTHIODIPHENYLAMINE.
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2975175A (en) * 1956-12-27 1961-03-14 Rhone Poulenc Sa Phenthiazine derivatives
US3065251A (en) * 1959-08-31 1962-11-20 Merck & Co Inc Substituted phenazasilines
US3109022A (en) * 1960-06-23 1963-10-29 Parke Davis & Co Nu-aryl anthranilic acids
US3185707A (en) * 1961-04-19 1965-05-25 Mcneilab Inc Alpha substituted phenyl aceto nitriles and hydrocinnamonitriles and the corresponding carbamates thereof
US5922887A (en) * 1995-05-19 1999-07-13 Smithkline Beecham Spa Diaryldiamine derivatives and their use as delta opiod (ANT)-agonists

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE550327C (en) * 1930-10-24 1932-05-20 I G Farbenindustrie Akt Ges Process for the preparation of basic substituted ethers or thioether
US2642433A (en) * 1949-11-17 1953-06-16 Hoffmann La Roche Alpha-amino-alpha, alpha-diphenylacetic acid derivatives and method of preparing same
US2745837A (en) * 1954-01-21 1956-05-15 Schering Corp Benzhydryl ethers of alkyl piperidinols

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE550327C (en) * 1930-10-24 1932-05-20 I G Farbenindustrie Akt Ges Process for the preparation of basic substituted ethers or thioether
US2642433A (en) * 1949-11-17 1953-06-16 Hoffmann La Roche Alpha-amino-alpha, alpha-diphenylacetic acid derivatives and method of preparing same
US2745837A (en) * 1954-01-21 1956-05-15 Schering Corp Benzhydryl ethers of alkyl piperidinols

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2975175A (en) * 1956-12-27 1961-03-14 Rhone Poulenc Sa Phenthiazine derivatives
US3065251A (en) * 1959-08-31 1962-11-20 Merck & Co Inc Substituted phenazasilines
US3109022A (en) * 1960-06-23 1963-10-29 Parke Davis & Co Nu-aryl anthranilic acids
US3185707A (en) * 1961-04-19 1965-05-25 Mcneilab Inc Alpha substituted phenyl aceto nitriles and hydrocinnamonitriles and the corresponding carbamates thereof
US5922887A (en) * 1995-05-19 1999-07-13 Smithkline Beecham Spa Diaryldiamine derivatives and their use as delta opiod (ANT)-agonists

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