GB810264A - Manufacture of a 17-hydroxysteroid - Google Patents

Manufacture of a 17-hydroxysteroid

Info

Publication number
GB810264A
GB810264A GB3857/56A GB385756A GB810264A GB 810264 A GB810264 A GB 810264A GB 3857/56 A GB3857/56 A GB 3857/56A GB 385756 A GB385756 A GB 385756A GB 810264 A GB810264 A GB 810264A
Authority
GB
United Kingdom
Prior art keywords
acids
per
pregnene
acid
acetylamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3857/56A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Farbwerke Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG, Farbwerke Hoechst AG filed Critical Hoechst AG
Publication of GB810264A publication Critical patent/GB810264A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

D 5 - 17 a - Hydroxy - pregnene - ol - (3b ) - one-(20) is prepared by oxidizing D 5 : 17(20)-pregnadiene - ol - (3b ) - acylamine - (20) - acylate with an organic per-acid to form 17,20-oxido- D 5 - pregnene - ol - (3b ) - acetylamine - (20) - acylate which is then hydrolysed. Suitable organic per-acids are aromatic per-acids such as perbenzoic and monoperphthalic acids and saturated aliphatic per-acids such as performic, peracetic and persuccinic acids. The per-acid may be formed in situ by the addition of a peroxide, for example, sodium or barium peroxide, to the corresponding organic acid, or a mixture of hydrogen peroxide and glacial acetic acid may be used. The hydrolysis may be carried out with dilute alkalies such as dilute sodium or potassium hydroxide solution. In the example D 5 - 17a - hydroxy - pregnene - ol - (3b ) - one - (20) is prepared from D 5 : 17(20)-pregnadiene-ol -(3b ) - acetylamine - (20) - acetate, the intermediate compound being 17 : 20-oxido- D 5 - pregnene - ol - (3b ) - acetylamine - (20) - acetate. Specification 780,970 is referred to.
GB3857/56A 1955-02-07 1956-02-07 Manufacture of a 17-hydroxysteroid Expired GB810264A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE810264X 1955-02-07

Publications (1)

Publication Number Publication Date
GB810264A true GB810264A (en) 1959-03-11

Family

ID=6724237

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3857/56A Expired GB810264A (en) 1955-02-07 1956-02-07 Manufacture of a 17-hydroxysteroid

Country Status (1)

Country Link
GB (1) GB810264A (en)

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