GB759743A - Steroids - Google Patents
SteroidsInfo
- Publication number
- GB759743A GB759743A GB36949/54A GB3694954A GB759743A GB 759743 A GB759743 A GB 759743A GB 36949/54 A GB36949/54 A GB 36949/54A GB 3694954 A GB3694954 A GB 3694954A GB 759743 A GB759743 A GB 759743A
- Authority
- GB
- United Kingdom
- Prior art keywords
- diepoxypregnan
- acid
- diacyloxy
- pregnene
- effected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises a 3-oxygenated 5a (6a ), 16a (17a )-diepoxypregnan-20-one of the formula <FORM:0759743/IV(a)/1> wherein R represents hydrogen or an acyl radical of a hydrocarbon carboxylic acid containing up to and including eight carbon atoms, and the preparation thereof by mixing a 3b ,20-diacyloxy-5,16,20-pregnatriene with an organic peracid, e.g. perbenzoic, peracetic, performic or monoperphthalic acid at a temperature between -10 DEG and +40 DEG C. to give a 3b ,20-diacyloxy-5a (6a ), 16a (17a ) - diepoxy - 20 - pregnene and hydrolysing the thus-obtained diepoxy-20-pregnene with a strong base to obtain 3b -hydroxy - 5a (6a ), 16a (17a ) - diepoxypregnan-20-one, and treating the latter with an acylating agent such as ketene, isopropenyl acylate, an acid anhydride, an acid chloride or an acid bromide. The hydrolysis may be effected by means of an alkali hydroxide, sodamide, calcium hydroxide, barium hydroxide or sodium carbonate. The acylation may be effected in pyridine, benzene, toluene or ether as solvent. Examples describe the production of 3b -hydroxy - 5a (6a ), 16a (17a ) - diepoxypregnan - 20-one and the corresponding 3b -acetoxy-, 3b -propionyloxy-, 3b -benzoyloxy- and 3b -(b -cyclopentylpropionyloxy)-esters thereof. Specification 759,247 is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US759743XA | 1954-01-04 | 1954-01-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB759743A true GB759743A (en) | 1956-10-24 |
Family
ID=22129099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB36949/54A Expired GB759743A (en) | 1954-01-04 | 1954-12-21 | Steroids |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB759743A (en) |
-
1954
- 1954-12-21 GB GB36949/54A patent/GB759743A/en not_active Expired
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB759743A (en) | Steroids | |
GB868303A (en) | New cyclopentanophenanthrene derivatives and process for the production thereof | |
GB595539A (en) | 1:4-dichloro- and 1:4-dibromo-2-butines | |
GB843664A (en) | Preparation of 3ª‰-hydroxy-6-methyl-25d-spirost-5-ene or the 3ª‰-acyl derivatives thereof | |
GB759247A (en) | Steroids | |
GB810264A (en) | Manufacture of a 17-hydroxysteroid | |
GB746096A (en) | Production of -a-(n-(-a-diethylaminoethyl))-aminophenylacetic acid isoamyl ester hydrochloride | |
GB729610A (en) | Oxido-steroids | |
GB733052A (en) | Manufacture of genins | |
GB739175A (en) | Steroid compounds | |
GB865316A (en) | Improvements in or relating to steroids and the manufacture thereof | |
GB915636A (en) | Novel alkylated pregnadienes | |
GB766326A (en) | Penicillin salts of an ester of 4-aminosalicylic acid | |
GB719068A (en) | Manufacture of substituted amino-acetoacetic acid esters | |
GB805584A (en) | Steroid compounds | |
GB695520A (en) | Production of cholanic acid derivatives | |
GB763197A (en) | Substituted phenanthrene compounds and their preparation | |
GB928226A (en) | Steroid compounds | |
GB741013A (en) | Steroid compounds | |
GB763205A (en) | Polyhydrophenanthrene compounds | |
GB759615A (en) | Improvements in or relating to the preparation of steroid substances | |
GB736182A (en) | Halogenation of steroid compounds | |
GB914739A (en) | New cyclopentano-naphthalene derivatives and processes for their production | |
GB593013A (en) | Improvements in and relating to the production of dl-n-formyl-isopropylidene-penicillamine l-brucine salt | |
GB724148A (en) | Steroids |