GB797469A - Preparation of 2-amino-5-mercapto-1, 3, 4-thiadiazoles - Google Patents

Preparation of 2-amino-5-mercapto-1, 3, 4-thiadiazoles

Info

Publication number
GB797469A
GB797469A GB16080/56A GB1608056A GB797469A GB 797469 A GB797469 A GB 797469A GB 16080/56 A GB16080/56 A GB 16080/56A GB 1608056 A GB1608056 A GB 1608056A GB 797469 A GB797469 A GB 797469A
Authority
GB
United Kingdom
Prior art keywords
mercapto
amino
thiadiazoles
preparation
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB16080/56A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of GB797469A publication Critical patent/GB797469A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

2 - Amino - 5 - mercapto - 1:3:4 - thiadiazoles are prepared by the ring closure of an N:N1 - bis - (thiocarbamyl hydrazine in the presence of hydrochloric and/or hydrobromic acid and from 0.05 to 30 parts by weight (preferably 0.60 to 2.0 parts by weight) of hypophosphorous acid per 100 parts by weight of said N:N1 - bis - (thiocarbamyl) hydrazine. The hydrohalic acid may be employed as a 1 to 12 N and preferably as a 2 to 4 N solution. Reaction temperatures are preferably from 90 DEG C. to reflux. The examples describe the preparation of 2 - amino - 5 - mercapto - 1:3:4 - thiadiazole. Specifications 687,760 and 726,045 are referred to.
GB16080/56A 1955-10-27 1956-05-24 Preparation of 2-amino-5-mercapto-1, 3, 4-thiadiazoles Expired GB797469A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US797469XA 1955-10-27 1955-10-27

Publications (1)

Publication Number Publication Date
GB797469A true GB797469A (en) 1958-07-02

Family

ID=22152543

Family Applications (1)

Application Number Title Priority Date Filing Date
GB16080/56A Expired GB797469A (en) 1955-10-27 1956-05-24 Preparation of 2-amino-5-mercapto-1, 3, 4-thiadiazoles

Country Status (1)

Country Link
GB (1) GB797469A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4374993A (en) * 1981-06-08 1983-02-22 Eastman Kodak Company Process for the preparation of the sulfate salt of 2-amino-5-alkylthio-1,3,4-thiadiazoles
CN116063244A (en) * 2021-11-02 2023-05-05 宁夏常晟药业有限公司 Synthesis method of 2-amino-5-mercapto-1, 3, 4-thiadiazole

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4374993A (en) * 1981-06-08 1983-02-22 Eastman Kodak Company Process for the preparation of the sulfate salt of 2-amino-5-alkylthio-1,3,4-thiadiazoles
CN116063244A (en) * 2021-11-02 2023-05-05 宁夏常晟药业有限公司 Synthesis method of 2-amino-5-mercapto-1, 3, 4-thiadiazole

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