GB792158A - Improvements relating to methyl-4-beta-halogenoethyl-5-thiazoles and salts thereof - Google Patents
Improvements relating to methyl-4-beta-halogenoethyl-5-thiazoles and salts thereofInfo
- Publication number
- GB792158A GB792158A GB31342/55A GB3134255A GB792158A GB 792158 A GB792158 A GB 792158A GB 31342/55 A GB31342/55 A GB 31342/55A GB 3134255 A GB3134255 A GB 3134255A GB 792158 A GB792158 A GB 792158A
- Authority
- GB
- United Kingdom
- Prior art keywords
- beta
- methyl
- salts
- halogenoethyl
- thiazoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Abstract
The invention comprises the methane sulphonates, and the alpha- and beta-camphosulphonates of 4-methyl-5-beta-halogenoethylthiazoles, and a process for the preparation of 4 - methyl - 5 - beta - halogenoethyl - thiazoles and their hydrohalide salts by reacting thionyl chloride or phosphorus bromide at a temperature of - 10 DEG to 0 DEG C. with 4-methyl-5-betahydroxyethyl-thiazole in chloroform and crystallizing the hydrohalide salt formed and, if desired, converting it into the free base, e.g. by neutralizing an aqueous solution of the hydrohalide salt with sodium bicarbonate. The 4 - methyl - 5 - beta - halogenoethyl - thiazoles may be converted into the methane sulphonates and the optically active or racemic alpha or beta camphosulphonate salts by treating a solution in acetone of the free base with the required acids. In the examples, 4-methyl - 5 - beta - chloroethyl - thiazole and the hydrochloride, methane sulphonate and optically active and racemic alpha- and beta-camphosulphonate salts thereof, and 4-methyl 5-beta - bromoethyl - thiazole and the hydrobromide salt thereof are prepared.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR792158X | 1955-09-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB792158A true GB792158A (en) | 1958-03-19 |
Family
ID=9229138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB31342/55A Expired GB792158A (en) | 1955-09-28 | 1955-11-02 | Improvements relating to methyl-4-beta-halogenoethyl-5-thiazoles and salts thereof |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB792158A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3031457A (en) * | 1955-09-28 | 1962-04-24 | Charonnat Solange Costes | Salts of 4-methyl-5 (beta-halogenoethyl)-thiazole and certain sulfonic acids |
-
1955
- 1955-11-02 GB GB31342/55A patent/GB792158A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3031457A (en) * | 1955-09-28 | 1962-04-24 | Charonnat Solange Costes | Salts of 4-methyl-5 (beta-halogenoethyl)-thiazole and certain sulfonic acids |
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