GB778728A - A carboxy-phenyl sulphonamide derivative - Google Patents
A carboxy-phenyl sulphonamide derivativeInfo
- Publication number
- GB778728A GB778728A GB2560354A GB2560354A GB778728A GB 778728 A GB778728 A GB 778728A GB 2560354 A GB2560354 A GB 2560354A GB 2560354 A GB2560354 A GB 2560354A GB 778728 A GB778728 A GB 778728A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carboxyphenylsulphonyl
- hexamethyleneimine
- nitrile
- reacting
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises N-(p-carboxyphenylsulphonyl) hexamethyleneimine. The compound is prepared by reacting a compound of the formula: <FORM:0778728/IV(b)/1> where X is a halogen atom and Y is a carboxyl, a nitrile or a carboxylic ester group, with hexamethylene imine in the presence of an acid-binding agent and, where necessary, hydrolysing the nitrile or carboxylic ester group to a carboxyl group. The reaction may be conducted in the presence of a diluent or of a solvent such as acetone. Acid-binding agents mentioned are hexamethyleneimine, pyridine or an aqueous solution of a hydroxide, carbonate or bicarbonate of an alkali or alkaline-earth metal such as aqueous sodium hydroxide. In an example, N-(p-carboxyphenylsulphonyl) hexamethyleneimine is prepared by reacting p-carboxyphenylsulphonyl chloride with hexamethyleneimine in the presence of aqueous sodium hydroxide solution.ALSO:The therapeutic action of penicillin in experimental animals is extended when N - (p - carboxyphenylsulphonyl) - hexamethylene - imine is also administered.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2560354A GB778728A (en) | 1954-09-03 | 1954-09-03 | A carboxy-phenyl sulphonamide derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2560354A GB778728A (en) | 1954-09-03 | 1954-09-03 | A carboxy-phenyl sulphonamide derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB778728A true GB778728A (en) | 1957-07-10 |
Family
ID=10230366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2560354A Expired GB778728A (en) | 1954-09-03 | 1954-09-03 | A carboxy-phenyl sulphonamide derivative |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB778728A (en) |
-
1954
- 1954-09-03 GB GB2560354A patent/GB778728A/en not_active Expired
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