GB765898A - Improvements in or relating to a process for the preparation of 5-nitro-2-furfural diacetate - Google Patents

Improvements in or relating to a process for the preparation of 5-nitro-2-furfural diacetate

Info

Publication number
GB765898A
GB765898A GB34777/54A GB3477754A GB765898A GB 765898 A GB765898 A GB 765898A GB 34777/54 A GB34777/54 A GB 34777/54A GB 3477754 A GB3477754 A GB 3477754A GB 765898 A GB765898 A GB 765898A
Authority
GB
United Kingdom
Prior art keywords
nitration
furfural
weight
nitric acid
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB34777/54A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Chilcott Pharmaceuticals Inc
Original Assignee
Norwich Pharmacal Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norwich Pharmacal Co filed Critical Norwich Pharmacal Co
Publication of GB765898A publication Critical patent/GB765898A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/02—Formation or introduction of functional groups containing nitrogen of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A process for the preparation of 5-nitro-2-furfural diacetate comprises nitrating furfural with concentrated nitric acid in the presence of acetic anhydride and a small proportion of an arsenic compound, followed by raising the pH of the reaction mixture by the addition of water and a base to convert the nitration intermediate. Technical nitric acid of 42 DEG to 43 DEG Baum<\>ae may be used for the nitration, preferably in the ratio of 1.15 parts by weight to each part by weight of furfural. The arsenic compound is preferably arsenic acid, preferably 0.0004 to 0.02 part by weight per part by weight of nitric acid being used. The temperature of the reaction mixture is preferably maintained below 40 DEG C. during the nitration reaction and the pH of the reaction is preferably raised to 3.7 (e.g. by addition of trisodium phosphate) after the nitration is completed.
GB34777/54A 1954-01-26 1954-12-01 Improvements in or relating to a process for the preparation of 5-nitro-2-furfural diacetate Expired GB765898A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US765898XA 1954-01-26 1954-01-26

Publications (1)

Publication Number Publication Date
GB765898A true GB765898A (en) 1957-01-16

Family

ID=22132995

Family Applications (1)

Application Number Title Priority Date Filing Date
GB34777/54A Expired GB765898A (en) 1954-01-26 1954-12-01 Improvements in or relating to a process for the preparation of 5-nitro-2-furfural diacetate

Country Status (1)

Country Link
GB (1) GB765898A (en)

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