GB758941A - Improvements in or relating to quaternary and tertiary amino carbinols - Google Patents
Improvements in or relating to quaternary and tertiary amino carbinolsInfo
- Publication number
- GB758941A GB758941A GB3427553A GB3427553A GB758941A GB 758941 A GB758941 A GB 758941A GB 3427553 A GB3427553 A GB 3427553A GB 3427553 A GB3427553 A GB 3427553A GB 758941 A GB758941 A GB 758941A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cyclohexyl
- phenyl
- hydrochloride
- general formula
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Compounds of the formula <FORM:0758941/IV(a)/1> where R1, R2 and R3 are alkyl groups of 1 to 3 carbon atoms or NR1R2 forms a piperidino or pyrrolidino ring, and X is chlorine or bromine, and the corresponding tertiary amine <FORM:0758941/IV(a)/2> and its hydrochloride or hydrobromide are made by reacting a carbinol of the general formula <FORM:0758941/IV(a)/3> wherein Y is a chlorine or bromine with an amine of the general formula NR1R2R3 or NHR1R2. In examples: (1) 1-cyclohexyl-1-phenyl - 3 - chloro - propan - 1 - ol is treated with pyrrolidine to give 1-cyclohexyl-1-phenyl-3 - pyrrolidinopropan - 1 - ol as the hydrochloride, and (2) 1-cyclohexyl-1-phenyl-3-chloropropan-1-ol is treated with N-methylpyrrolidine to give N-methyl-3-cyclohexyl-3-phenyl-3-hydroxy-propyl-pyrrolidinium chloride. By similar methods there may be prepared 1-cyclohexyl - 1 - phenyl - 3 - piperidino - 1 - ol hydrochloride, N - ethyl - 3 - cyclohexyl - 3-phenyl - 3 - hydroxypropyl - piperidinium chloride and N-methyl-N : N-diethyl-3-cyclohexyl - 3 - phenyl - 3 - hydroxypropylammonium chloride. Starting materials: 1-Cyclohexyl-1-phenyl-3-chloro (or bromo) propan-(1)-ols of the formula II are made by treating a ketone of the general formula C6H5COCH2CH2Y with a cyclohexyl Grignard reagent C6H11MgY and hydrolysing the reaction product. Specifications 627,139 and 624,118 mentioned in Provisional Specification are referred to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3427553A GB758941A (en) | 1953-12-09 | 1953-12-09 | Improvements in or relating to quaternary and tertiary amino carbinols |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3427553A GB758941A (en) | 1953-12-09 | 1953-12-09 | Improvements in or relating to quaternary and tertiary amino carbinols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB758941A true GB758941A (en) | 1956-10-10 |
Family
ID=10363595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3427553A Expired GB758941A (en) | 1953-12-09 | 1953-12-09 | Improvements in or relating to quaternary and tertiary amino carbinols |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB758941A (en) |
-
1953
- 1953-12-09 GB GB3427553A patent/GB758941A/en not_active Expired
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