GB875458A - Improvements in or relating to the preparation of 3-aminoisoxazoles - Google Patents
Improvements in or relating to the preparation of 3-aminoisoxazolesInfo
- Publication number
- GB875458A GB875458A GB32111/59A GB3211159A GB875458A GB 875458 A GB875458 A GB 875458A GB 32111/59 A GB32111/59 A GB 32111/59A GB 3211159 A GB3211159 A GB 3211159A GB 875458 A GB875458 A GB 875458A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkali
- aminoisoxazoles
- halogen
- carboxylic acid
- alkali metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
3-Aminoisoxazoles of the formula: <FORM:0875458/IV (b)/1> wherein R and R1, when individual, are each hydrogen or an alkyl, aryl or aralkyl radical and, when linked together, form a saturated or unsaturated hydrocarbon bridge (e.g. tetramethylene), are prepared by applying the Hofmann reaction to the corresponding isoxazole-3-carboxylic acid amides. Suitable reagents are halogen and alkali, halogen and alkali alcoholate or alkali metal (when alcohol solvents are used), alkali metal hypohalites and chloride of lime. Intermediates such as halogenoamides or urethane may occur as the main product and are transformed to the amine by heating with further amounts of alkali. N - Chloro - 5 - methylisoxazole-3-carboxylic acid amide may be isolated as an intermediate.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP875458X | 1958-09-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB875458A true GB875458A (en) | 1961-08-23 |
Family
ID=13917945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB32111/59A Expired GB875458A (en) | 1958-09-20 | 1959-09-21 | Improvements in or relating to the preparation of 3-aminoisoxazoles |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB875458A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3157669A (en) * | 1962-07-17 | 1964-11-17 | Hoffmann La Roche | Preparation of isoxazole compounds |
| US3290326A (en) * | 1963-09-20 | 1966-12-06 | Hoffmann La Roche | Esters of 4-lower alkyl-5-oxazole-car-bamic acid and intermediates therefor |
-
1959
- 1959-09-21 GB GB32111/59A patent/GB875458A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3157669A (en) * | 1962-07-17 | 1964-11-17 | Hoffmann La Roche | Preparation of isoxazole compounds |
| US3290326A (en) * | 1963-09-20 | 1966-12-06 | Hoffmann La Roche | Esters of 4-lower alkyl-5-oxazole-car-bamic acid and intermediates therefor |
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