GB757077A - Manufacture of indolyl compounds - Google Patents
Manufacture of indolyl compoundsInfo
- Publication number
- GB757077A GB757077A GB331/53A GB33153A GB757077A GB 757077 A GB757077 A GB 757077A GB 331/53 A GB331/53 A GB 331/53A GB 33153 A GB33153 A GB 33153A GB 757077 A GB757077 A GB 757077A
- Authority
- GB
- United Kingdom
- Prior art keywords
- indolyl
- products
- phenyl
- methoxy
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000001041 indolyl group Chemical group 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000047 product Substances 0.000 abstract 6
- 238000006243 chemical reaction Methods 0.000 abstract 5
- -1 indolyl magnesium halide Chemical class 0.000 abstract 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- UVXYHQQDTXJQSE-UHFFFAOYSA-N 2-(1-ethyl-2-phenyl-4,5-dihydroimidazol-4-yl)-1H-indole hydrochloride Chemical compound Cl.N1C(=CC2=CC=CC=C12)C1N=C(N(C1)CC)C1=CC=CC=C1 UVXYHQQDTXJQSE-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 238000006114 decarboxylation reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000003840 hydrochlorides Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- ODUCDPQEXGNKDN-UHFFFAOYSA-N nitroxyl Chemical compound O=N ODUCDPQEXGNKDN-UHFFFAOYSA-N 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE314486X | 1952-01-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB757077A true GB757077A (en) | 1956-09-12 |
Family
ID=6146171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB331/53A Expired GB757077A (en) | 1952-01-05 | 1953-01-05 | Manufacture of indolyl compounds |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US2752358A (enExample) |
| CH (1) | CH314486A (enExample) |
| GB (1) | GB757077A (enExample) |
| NL (1) | NL82464C (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3732245A (en) * | 1970-11-04 | 1973-05-08 | Hoffmann La Roche | Process and intermediates for the preparation of indoles from ortho-nitrotoluenes |
| US6821264B1 (en) | 2000-11-27 | 2004-11-23 | Gautam Khurana | Gene delivery device and gene delivery method |
| PL376596A1 (pl) * | 2002-10-24 | 2006-01-09 | Colgate-Palmolive Company | Materiał silikonowy modyfikowanego poliamidu stosowany do ochrony jamy ustnej |
| RU2382031C2 (ru) * | 2004-06-01 | 2010-02-20 | Ф. Хоффманн-Ля Рош Аг | 3-амино-1-арилпропилиндолы, применяемые в качестве ингибиторов обратного захвата моноаминов |
| KR20080080593A (ko) | 2005-11-30 | 2008-09-04 | 에프. 호프만-라 로슈 아게 | 3-아미노-1-아릴프로필 인돌의 합성 방법 |
| JP2009517432A (ja) * | 2005-11-30 | 2009-04-30 | エフ．ホフマン−ラ ロシュ アーゲー | ３−アミノ−２−アリールプロピルアザインドールおよびその使用 |
| AU2006319231A1 (en) * | 2005-11-30 | 2007-06-07 | F. Hoffmann-La Roche Ag | 3-amino-1-arylpropyl indoles and aza-substituted indoles |
| DE102008030207A1 (de) * | 2008-06-25 | 2009-12-31 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 7-Sulfanylmethyl-, 7-Sulfinylmethyl- und 7-Sulfonylmethyl-Indole und ihre Verwendung |
| DE102008030206A1 (de) | 2008-06-25 | 2009-12-31 | Bayer Schering Pharma Aktiengesellschaft | 3-Cyanoalky- und 3-Hydroxyalkyl-Indole und ihre Verwendung |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2505247A (en) * | 1950-04-25 | Process fob the preparation of | ||
| US2161938A (en) * | 1934-07-31 | 1939-06-13 | Soc Of Chemical Ind | Imidazolines |
| US2252723A (en) * | 1938-05-11 | 1941-08-19 | Ciba Pharm Prod Inc | Halogen-alkyl amidines and process of preparing same |
| DE701322C (de) * | 1938-05-11 | 1941-01-14 | Chemische Ind Ges | Verfahren zur Darstellung von Imidazolin- und Tetrahydropyrimidinverbindungen |
-
0
- NL NL82464D patent/NL82464C/xx active
-
1952
- 1952-12-30 US US328831A patent/US2752358A/en not_active Expired - Lifetime
-
1953
- 1953-01-05 GB GB331/53A patent/GB757077A/en not_active Expired
- 1953-01-05 CH CH314486D patent/CH314486A/de unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH314486A (de) | 1956-06-15 |
| NL82464C (enExample) | |
| US2752358A (en) | 1956-06-26 |
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