GB736816A - A new trypanocidal substance and its acid addition salts - Google Patents
A new trypanocidal substance and its acid addition saltsInfo
- Publication number
- GB736816A GB736816A GB31705/52A GB3170552A GB736816A GB 736816 A GB736816 A GB 736816A GB 31705/52 A GB31705/52 A GB 31705/52A GB 3170552 A GB3170552 A GB 3170552A GB 736816 A GB736816 A GB 736816A
- Authority
- GB
- United Kingdom
- Prior art keywords
- addition salt
- acid
- diamino
- oxide
- trypanocidal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 7
- 239000002253 acid Substances 0.000 title abstract 3
- 230000000654 trypanocidal effect Effects 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 4
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 abstract 4
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 abstract 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 2
- VOLTUGUMYQENMY-UHFFFAOYSA-N 4-arsorosoaniline Chemical compound NC1=CC=C([As]=O)C=C1 VOLTUGUMYQENMY-UHFFFAOYSA-N 0.000 abstract 1
- ZPKGNACMIIMUNF-UHFFFAOYSA-N C(O)(O)=O.[AsH3]=O Chemical compound C(O)(O)=O.[AsH3]=O ZPKGNACMIIMUNF-UHFFFAOYSA-N 0.000 abstract 1
- 239000012670 alkaline solution Substances 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- CXKRDMQZBMZKKJ-UHFFFAOYSA-N arsine oxide Chemical compound [AsH3]=O CXKRDMQZBMZKKJ-UHFFFAOYSA-N 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 229940045996 isethionic acid Drugs 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 235000010269 sulphur dioxide Nutrition 0.000 abstract 1
- 239000004291 sulphur dioxide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/66—Arsenic compounds
- C07F9/70—Organo-arsenic compounds
- C07F9/80—Heterocyclic compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
4 - (2 : 6 - Diamino - 4 - pyrimidylamino)-phenylarsine oxide <FORM:0736816/IV (b)/1> is prepared by (a) reduction of 4-(2 : 6-diamino-4-pyrimidylamino)-phenyl arsonic acid with sulphur dioxide and hydrochloric acid in the presence of potassium iodide, and hydrolysing the dichloride so formed without purification and isolating the arsine oxide as its carbonate addition salt by passage of CO2 into the alkaline solution; or (b) reacting p-aminophenylarsine oxide with 2 : 6-diamino-4-chloropyrimidine and isolating the required product as its carbonate addition salt. Reaction (b) may be carried out in an acid medium, e.g. aqueous hydrochloric acid. The arsine oxide carbonate addition salt may be converted to the isethionate addition salt by reaction with isethionic acid (see Group VI) in an aqueous medium. Detailed examples are given. U.S.A. Specification 2,435,393 is referred to.ALSO:4 - (2:6 - diamino - 4 - pyrmiidylamino)-phenylarsine oxide <FORM:0736816/VI/1> and is acid addition salts (see Group IV (b)) may be used in trypanocidal compositions. In particular, the isethionate addition salt may be used in aqueous solution. U.S.A. Specification 2,435,393 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB326011X | 1952-12-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB736816A true GB736816A (en) | 1955-09-14 |
Family
ID=10341163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB31705/52A Expired GB736816A (en) | 1952-12-15 | 1952-12-15 | A new trypanocidal substance and its acid addition salts |
Country Status (4)
| Country | Link |
|---|---|
| CH (1) | CH326011A (en) |
| DE (1) | DE1003214B (en) |
| FR (1) | FR1096246A (en) |
| GB (1) | GB736816A (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2435393A (en) * | 1943-06-19 | 1948-02-03 | Parke Davis & Co | Arsenic derivatives and process of preparing same |
-
1952
- 1952-12-15 GB GB31705/52A patent/GB736816A/en not_active Expired
-
1953
- 1953-12-11 CH CH326011D patent/CH326011A/en unknown
- 1953-12-12 FR FR1096246D patent/FR1096246A/en not_active Expired
- 1953-12-14 DE DEI8045A patent/DE1003214B/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CH326011A (en) | 1957-11-30 |
| DE1003214B (en) | 1957-02-28 |
| FR1096246A (en) | 1955-06-16 |
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