GB716059A - Improvements in medical preparations for the treatment of high blood pressure - Google Patents
Improvements in medical preparations for the treatment of high blood pressureInfo
- Publication number
- GB716059A GB716059A GB6302/52A GB630252A GB716059A GB 716059 A GB716059 A GB 716059A GB 6302/52 A GB6302/52 A GB 6302/52A GB 630252 A GB630252 A GB 630252A GB 716059 A GB716059 A GB 716059A
- Authority
- GB
- United Kingdom
- Prior art keywords
- solution
- acid
- ethylene diamine
- acetic
- pyrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A pyrogen-free aqueous solution of an alkali-metal salt of a magnesium chelate compound of ethylene diamine-N,N1-tetra-acetic acid at pH 7.2-7.4 is used for medical injection. The disodium compound is produced by dissolving repeatedly crystallized ethylene diamine tetracetic acid in a pyrogen-free aqueous solution of 2 mols. pure sodium hydroxide per mol. acid with agitation and gentle heating, and adding 1 mol. magnesium chloride, acetate, oxide, hydroxide or carbonate. The solution is concentrated by boiling and the pH adjusted by addition of hydrochloric, acetic or citric acid, or of sodium hydroxide.ALSO:A preparation for injection, to reduce by base-exchange the calcium ions in the bloodstream, consists of a pyrogen-free aqueous, suitably isotonic, solution of an alkali metal salt of a magnesium chelate compound of ethylene diamine N, N1 tetraacetic acid having a pH of 7.2-7.4. Alternatively, the solution is incorporated in a water-miscible ointment for absorption through the skin. Isotonic solutions suitably contain 5 per cent glucose. The disodium magnesium chelate compound is produced from pure ethylene diamine tetra-acetic acid (see Group IV (b)), the pH of the solution being finally brought to 7.2-7.4 by addition of hydrochloric, acetic or citric acid, or of sodium hydroxide.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US716059XA | 1951-03-17 | 1951-03-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB716059A true GB716059A (en) | 1954-09-29 |
Family
ID=22102395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB6302/52A Expired GB716059A (en) | 1951-03-17 | 1952-03-11 | Improvements in medical preparations for the treatment of high blood pressure |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB716059A (en) |
-
1952
- 1952-03-11 GB GB6302/52A patent/GB716059A/en not_active Expired
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB576909A (en) | Improvements in the bleaching of organic materials | |
| GB716059A (en) | Improvements in medical preparations for the treatment of high blood pressure | |
| GB715976A (en) | Improvements in medical preparations for removing toxic heavy metals from the human body | |
| GB748024A (en) | Improved therapeutic preparations of iron | |
| GB1304595A (en) | ||
| GB827578A (en) | A process for the purification of an alkali metal hypophosphite solution containing alkali metal phosphite | |
| GB934292A (en) | Process for the preparation of heterocyclic compounds | |
| GB715848A (en) | Improvements in medicinal preparations for the treatment of calcifications in human and animal systems | |
| GB475291A (en) | Process of preparing nutritive amino-acid preparations | |
| GB770075A (en) | Improvements in or relating to preparation of a fibrinogen product and stable solutions thereof | |
| GB613080A (en) | Improvements in the preparation of stable medicinal salts of acetylsalicylic acid | |
| GB683423A (en) | Improvements in and relating to antibiotic substances produced by group n streptococcus lactis | |
| US2098976A (en) | Medicinal preparations containing metal compounds of decomposition products of nucleoproteins | |
| GB1033736A (en) | Stable injectable protamine-active compositions | |
| GB516634A (en) | Improvements in or relating to the production of solutions of low substituted cellulose ethers | |
| GB579970A (en) | Manufacture of lactic acid and salts thereof | |
| GB894752A (en) | Improvements in or relating to citric acid derivatives | |
| GB786917A (en) | Para-aminosalicylic acids | |
| GB733886A (en) | Process of producing glucoheptonic acid and/or calcium glucoheptonate for the preparation of derivatives thereof | |
| GB768639A (en) | Method for ensilage of grass and green fodder | |
| GB870397A (en) | Improvements relating to methods of preparing solutions, particularly for waterproofing | |
| GB1172470A (en) | A Novel Imidazole Compound and a Process for Producing the same | |
| GB813960A (en) | An improved clinical dextran and method for producing the same | |
| GB608771A (en) | Improvements in or relating to an aqueous non-alcoholic vanillin-containing flavouring composition | |
| GB561013A (en) | Production of ª‰-alanine and ª‰-alanates |