GB703961A - Improvements in derivatives of stilbazoline - Google Patents

Improvements in derivatives of stilbazoline

Info

Publication number
GB703961A
GB703961A GB5362/52A GB536252A GB703961A GB 703961 A GB703961 A GB 703961A GB 5362/52 A GB5362/52 A GB 5362/52A GB 536252 A GB536252 A GB 536252A GB 703961 A GB703961 A GB 703961A
Authority
GB
United Kingdom
Prior art keywords
methyl
iodide
alkyl
conversion
mol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5362/52A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of GB703961A publication Critical patent/GB703961A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

The invention comprises bis-quaternary stilbazolinium salts of the formula <FORM:0703961/IV(b)/1> where R and R1 are alkyl of 1-4 carbon atoms, one being methyl, S denotes saturation of the ring and X is the anion of an acid. These are made from N-alkyl-41-dimethylamino-g -stil - bazoline hydriodides by (1) conversion to free base and treatment with 2 mols. of methyl iodide to give the product (R1 = methyl); or (2) addition of one mol. of R1, conversion to free base and treatment with one mol. of methyl iodide. Alternatively N-alkyl-41-methylethylamino-stilbazoline hydriodide may be used as starting material; this is obtained from an alkyl-g -picolinium iodide and p-methylethylaminobenzaldehyde followed by catalytic hydrogenation. The above processes yield products where X is iodide; other salts may be obtained by using a different quaternating agent (e.g. a bromide or sulphate) or by subsequent conversion, e.g. into chlorides and nitrates. Examples show the production of compounds (1) R = R1 = methyl, X = iodide, converted into chloride, (2) R = ethyl, R1 = methyl, X = iodide, (3) R = methyl, R1 = ethyl, X = iodide. R or R1 may also be n-propyl or n-butyl.
GB5362/52A 1951-03-29 1952-02-29 Improvements in derivatives of stilbazoline Expired GB703961A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US703961XA 1951-03-29 1951-03-29

Publications (1)

Publication Number Publication Date
GB703961A true GB703961A (en) 1954-02-10

Family

ID=22095042

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5362/52A Expired GB703961A (en) 1951-03-29 1952-02-29 Improvements in derivatives of stilbazoline

Country Status (1)

Country Link
GB (1) GB703961A (en)

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