GB667923A - Process for preparing 3.4-dihydroxypyrrolidines - Google Patents
Process for preparing 3.4-dihydroxypyrrolidinesInfo
- Publication number
- GB667923A GB667923A GB12871/50A GB1287150A GB667923A GB 667923 A GB667923 A GB 667923A GB 12871/50 A GB12871/50 A GB 12871/50A GB 1287150 A GB1287150 A GB 1287150A GB 667923 A GB667923 A GB 667923A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyrrolidines
- dihydroxypyrrolidines
- amines
- compounds
- over
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pyrrole Compounds (AREA)
Abstract
3 : 4-Dihydroxypyrrolidines are obtained by heating 1 : 4-diarylamino-, or diaralkylamino-2 : 3-dihydroxybutanes to temperatures over 200 DEG C., when ring closure and elimination of amine takes place. Mixtures of amines and butane derivatives which yield the above intermediate compounds may be directly converted into pyrrolidines without isolating the power. In examples: 1 : 4-dianilino-2 : 3-di-hydroxybutane, obtainable by the action of aniline on butadiene dioxide or on the dichlorhydrin or dibromhydrin of racemic erythritol, and the corresponding 1 : 4-dianisidyl-, di-benzylamino-, dimeta- or para chloranilino-compounds are heated at over 200 DEG C. with evolution of the respective amines to give the 3 : 4 - dihydroxy - pyrrolidines, N - substituted. N-ortho-tolyl- and N-phenetyl-pyrrolidine may be obtained similarly.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE667923X | 1949-05-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB667923A true GB667923A (en) | 1952-03-12 |
Family
ID=6589948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB12871/50A Expired GB667923A (en) | 1949-05-28 | 1950-05-23 | Process for preparing 3.4-dihydroxypyrrolidines |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB667923A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3312716A (en) * | 1964-08-11 | 1967-04-04 | Aldrich Chem Co Inc | 4-hydroxy-3-pyrrolidinemethanols |
WO1992005152A2 (en) * | 1990-09-17 | 1992-04-02 | Mcneilab, Inc. | Process for producing polyhydroxylated piperidines and pyrrolidines and compounds thereof |
-
1950
- 1950-05-23 GB GB12871/50A patent/GB667923A/en not_active Expired
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3312716A (en) * | 1964-08-11 | 1967-04-04 | Aldrich Chem Co Inc | 4-hydroxy-3-pyrrolidinemethanols |
WO1992005152A2 (en) * | 1990-09-17 | 1992-04-02 | Mcneilab, Inc. | Process for producing polyhydroxylated piperidines and pyrrolidines and compounds thereof |
WO1992005152A3 (en) * | 1990-09-17 | 1992-05-14 | Mcneilab Inc | Process for producing polyhydroxylated piperidines and pyrrolidines and compounds thereof |
US5290948A (en) * | 1990-09-17 | 1994-03-01 | Mcneilab, Inc. | Process for producing polyhydroxylated piperidines and pyrrolidines and compounds thereof |
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