GB1002856A - Pyrrolidine derivatives - Google Patents
Pyrrolidine derivativesInfo
- Publication number
- GB1002856A GB1002856A GB41661/60A GB4166160A GB1002856A GB 1002856 A GB1002856 A GB 1002856A GB 41661/60 A GB41661/60 A GB 41661/60A GB 4166160 A GB4166160 A GB 4166160A GB 1002856 A GB1002856 A GB 1002856A
- Authority
- GB
- United Kingdom
- Prior art keywords
- substituted
- phthalyl
- mono
- ethyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of general formula <FORM:1002856/C2/1> wherein X represents the radical of a cyclic imide of an aromatic, substituted aromatic, aliphatic or substituted aliphatic dicarboxylic acid attached to the pyrrolidine ring by its imido-nitrogen atom, and R represents hydrogen or a lower (1-7 C) aliphatic group; and their preparation by treatment of an X-substituted succinic acid or functional derivative thereof to effect ring closure through a nitrogen atom, in particular by heating the mono- or diamide with a dehydrating agent or by treatment of the acid or derivative with a urea, amine or mono- or di-carboxylic acid amide. Isomers are obtained using appropriate starting materials. Subsequent modification of substituents X and R is mentioned particularly by nitration, which may be followed by reduction, of a phthalimido substituent X, and by 1-hydroxyethylation. g - N - (Methyl or ethyl) - a - N - phthalyl - asparagines are prepared from N-phthalyl-asparagine and methyl- and ethyl-amines.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB41661/60A GB1002856A (en) | 1960-12-03 | 1960-12-03 | Pyrrolidine derivatives |
| FR880621A FR2055M (en) | 1960-12-03 | 1961-12-01 | New derivatives of pyrrolidine. |
| CH1403461A CH419128A (en) | 1960-12-03 | 1961-12-02 | Process for the preparation of pyrrolidine derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB41661/60A GB1002856A (en) | 1960-12-03 | 1960-12-03 | Pyrrolidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1002856A true GB1002856A (en) | 1965-09-02 |
Family
ID=10420712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB41661/60A Expired GB1002856A (en) | 1960-12-03 | 1960-12-03 | Pyrrolidine derivatives |
Country Status (3)
| Country | Link |
|---|---|
| CH (1) | CH419128A (en) |
| FR (1) | FR2055M (en) |
| GB (1) | GB1002856A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11395820B2 (en) | 2016-03-16 | 2022-07-26 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Small molecules against cereblon to enhance effector t cell function |
| US11730726B2 (en) | 2018-07-11 | 2023-08-22 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Dimeric immuno-modulatory compounds against cereblon-based mechanisms |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0031297A3 (en) * | 1979-12-07 | 1981-07-15 | Ciba-Geigy Ag | 2,5 dioxo pyrrolidin compounds, process for their preparation and their use as microbicides |
-
1960
- 1960-12-03 GB GB41661/60A patent/GB1002856A/en not_active Expired
-
1961
- 1961-12-01 FR FR880621A patent/FR2055M/en active Active
- 1961-12-02 CH CH1403461A patent/CH419128A/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11395820B2 (en) | 2016-03-16 | 2022-07-26 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Small molecules against cereblon to enhance effector t cell function |
| US11730726B2 (en) | 2018-07-11 | 2023-08-22 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Dimeric immuno-modulatory compounds against cereblon-based mechanisms |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2055M (en) | 1963-10-07 |
| CH419128A (en) | 1966-08-31 |
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