GB666629A - Improvements in or relating to thiouracil compounds - Google Patents

Improvements in or relating to thiouracil compounds

Info

Publication number
GB666629A
GB666629A GB32063/49A GB3206349A GB666629A GB 666629 A GB666629 A GB 666629A GB 32063/49 A GB32063/49 A GB 32063/49A GB 3206349 A GB3206349 A GB 3206349A GB 666629 A GB666629 A GB 666629A
Authority
GB
United Kingdom
Prior art keywords
propyl
methylthiouracil
thiouracil
relating
ketocaproic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB32063/49A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Societe des Usines Chimiques Rhone Poulenc SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc SA, Societe des Usines Chimiques Rhone Poulenc SA filed Critical Rhone Poulenc SA
Publication of GB666629A publication Critical patent/GB666629A/en
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

6-Propyl-2-thiouracil is manufactured by reacting S-methylisothiourea (conveniently in the form of its sulphate) with a b -ketocaproic acid ester in the presence of a strong alkali (preferably sodium ethoxide), and demethylating the resulting 6-propyl-2-methylthiouracil by heating with at least the theoretical quantity of an alkali metal (e.g. potassium) hydrosulphide, preferably under superatmospheric pressure. The condensation is preferably effected by allowing the reagents to stand together at room temperature in an anhydrous solvent (e.g. methyl or ethyl alcohols), and the 6-propyl-2-methylthiouracil may be isolated from the reaction mixture by dilution with water, filtration and acidification of the filtrate. In an example, the starting material is the ethyl ester of b -ketocaproic acid.
GB32063/49A 1948-12-20 1949-12-14 Improvements in or relating to thiouracil compounds Expired GB666629A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR666629X 1948-12-20

Publications (1)

Publication Number Publication Date
GB666629A true GB666629A (en) 1952-02-13

Family

ID=9013969

Family Applications (1)

Application Number Title Priority Date Filing Date
GB32063/49A Expired GB666629A (en) 1948-12-20 1949-12-14 Improvements in or relating to thiouracil compounds

Country Status (1)

Country Link
GB (1) GB666629A (en)

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