Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB32063/49A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Societe des Usines Chimiques Rhone Poulenc SA
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Filing date
Publication date
Application filed by Rhone Poulenc SA, Societe des Usines Chimiques Rhone Poulenc SAfiledCriticalRhone Poulenc SA
Publication of GB666629ApublicationCriticalpatent/GB666629A/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
6-Propyl-2-thiouracil is manufactured by reacting S-methylisothiourea (conveniently in the form of its sulphate) with a b -ketocaproic acid ester in the presence of a strong alkali (preferably sodium ethoxide), and demethylating the resulting 6-propyl-2-methylthiouracil by heating with at least the theoretical quantity of an alkali metal (e.g. potassium) hydrosulphide, preferably under superatmospheric pressure. The condensation is preferably effected by allowing the reagents to stand together at room temperature in an anhydrous solvent (e.g. methyl or ethyl alcohols), and the 6-propyl-2-methylthiouracil may be isolated from the reaction mixture by dilution with water, filtration and acidification of the filtrate. In an example, the starting material is the ethyl ester of b -ketocaproic acid.
GB32063/49A1948-12-201949-12-14Improvements in or relating to thiouracil compounds
ExpiredGB666629A
(en)