GB655519A - Improvements in or relating to penicillin compositions - Google Patents

Improvements in or relating to penicillin compositions

Info

Publication number
GB655519A
GB655519A GB2887648A GB2887648A GB655519A GB 655519 A GB655519 A GB 655519A GB 2887648 A GB2887648 A GB 2887648A GB 2887648 A GB2887648 A GB 2887648A GB 655519 A GB655519 A GB 655519A
Authority
GB
United Kingdom
Prior art keywords
organic solvent
active agent
procaine penicillin
polyoxyalkylene
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2887648A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PERCY CHARLES HENRY VERDUN CLA
Distillers Co Biochemicals Ltd
Original Assignee
PERCY CHARLES HENRY VERDUN CLA
Distillers Co Biochemicals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PERCY CHARLES HENRY VERDUN CLA, Distillers Co Biochemicals Ltd filed Critical PERCY CHARLES HENRY VERDUN CLA
Priority to GB2887648A priority Critical patent/GB655519A/en
Publication of GB655519A publication Critical patent/GB655519A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Abstract

Solid readily dispersable preparations containing procaine penicillin are manufactured by intimately mixing (e.g. by trituration) procaine penicillin with a small amount (e.g. 0.1-1.0 per cent), of a water-soluble non-ionic surface-active agent in the presence of an organic solvent selected from lower aliphatic alcohols, ketones and chlorinated hydrocarbons, aliphatic carboxylic acid esters and aromatic hydrocarbons, and having a boiling point not substantially above 130 DEG C., at normal pressure, the organic solvent being thereafter removed, e.g. by the action of heat. Suitable solvents include methyl and n-butyl alcohol, ethyl, n- and isopropyl and n-butyl acetate, chloroform, carbon tetrachloride, dichlorethylene and especially acetone, whilst preferred surface-active agents are the polyoxyalkylene derivatives of partial esters of polyhydric alcohols having at most 10 hydroxy groups with fatty acids having at least 4 carbon atoms in the molecule, especially a polyoxyalkylene derivative of a hexitol inner anhydride partial long-chain fatty acid ester. In examples, the surface-active agent is polyoxyethylene sorbitan mono-oleate, alternatives to which are listed. Specifications 661,272 and 3806/46 (as open to inspection under Sect. 91) are referred to.ALSO:Solid readily dispersable preparations containing procaine penicillin are manufactured by intimately mixing (e.g. by trituration), procaine penicillin with a small amount (e.g. 0.1-1.0 per cent), of a water-soluble non-ionic surface active agent in the presence of an organic solvent selected from lower aliphatic alcohols, ketones and chlorinated hydrocarbons, aliphatic carboxylic acid esters and aromatic hydrocarbons, and having a boiling point not substantially above 130 DEG C at normal pressure, the organic solvent being thereafter removed, e.g. by the action of heat. The products, which may be distributed in vials, yield injectible suspensions by dispersing them in an injectible menstruum, especially water. Suitable organic solvents include methyl and n-butyl alcohol, ethyl, n-and iso-propyl and n-butyl acetate, chloroform, carbon tetrachloride, dichlorethylene and especially acetone, whilst preferred surface active agents are the polyoxyalkylene derivatives of partial esters of polyhydric alcohols having at most 10 hydroxy groups with fatty acids having at least 4 carbon atoms in the molecule, especially a polyoxyalkylene derivative of a hexitol inner anhydride partial long chain fatty acid ester. In examples, the surface active agent is polyoxyethylene sorbitan monooleate, alternatives to which are listed. Specifications 661,272 and 3806/46 (as open to inspection under Sect. 91), are referred to.
GB2887648A 1948-11-06 1948-11-06 Improvements in or relating to penicillin compositions Expired GB655519A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2887648A GB655519A (en) 1948-11-06 1948-11-06 Improvements in or relating to penicillin compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2887648A GB655519A (en) 1948-11-06 1948-11-06 Improvements in or relating to penicillin compositions

Publications (1)

Publication Number Publication Date
GB655519A true GB655519A (en) 1951-07-25

Family

ID=10282585

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2887648A Expired GB655519A (en) 1948-11-06 1948-11-06 Improvements in or relating to penicillin compositions

Country Status (1)

Country Link
GB (1) GB655519A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2890980A (en) * 1953-12-02 1959-06-16 American Cyanamid Co Anti-static medicated animal feedstuffs
US2963403A (en) * 1956-11-01 1960-12-06 Upjohn Co Defoamed surface-activated monocalcium novobiocin compositions
US4533542A (en) * 1983-08-22 1985-08-06 Eli Lilly And Company Pharmaceutical compositions for storage in plastic containers and process therefor
US4684643A (en) * 1983-08-22 1987-08-04 Eli Lilly And Company Pharmaceutical compositions for storage in plastic containers and process therefor

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2890980A (en) * 1953-12-02 1959-06-16 American Cyanamid Co Anti-static medicated animal feedstuffs
US2963403A (en) * 1956-11-01 1960-12-06 Upjohn Co Defoamed surface-activated monocalcium novobiocin compositions
US4533542A (en) * 1983-08-22 1985-08-06 Eli Lilly And Company Pharmaceutical compositions for storage in plastic containers and process therefor
US4684643A (en) * 1983-08-22 1987-08-04 Eli Lilly And Company Pharmaceutical compositions for storage in plastic containers and process therefor

Similar Documents

Publication Publication Date Title
ES2462946T3 (en) Enzymatic process to obtain 17-alpha cortexolone propionate in crystalline form III
GB688056A (en) Improvements in or relating to esters of chlorinated phenoxyacetic acids
GB1099974A (en) Process for the preparation of surfactants from hydroxylated organic compounds, fatty acid esters and alkylene oxides
GB911185A (en) Electrically conductive compositions
GB655519A (en) Improvements in or relating to penicillin compositions
US2285422A (en) Emulsion
GB689194A (en) Improvements in the production of mixed cellulose esters
US3095353A (en) Aqueous mixture of surface active agents
US2073256A (en) Solutions of organic chlorine compounds
GB766394A (en) Improvements in or relating to refining vegetable oils
GB996207A (en) Improved vitamin a compositions
NL128856C (en)
GB643765A (en) Improvements relating to emulsions of saturated fatty acids
GB669567A (en) Improvements in or relating to the preparation of derivatives of cyclohexane
GB951011A (en) Emulsifier blends
GB970789A (en) Process of esterification
JPS5573337A (en) Emulsifying or solubilizing composition
GB499794A (en) Manufacture of new esters of compounds of the oestrone series
US2387841A (en) Vinyl resin compositions
GB644828A (en) Esters of mixtures of polyoxyalkylene monohydroxy compounds
GB713720A (en) Improvements in or relating to the preparation of stabilized liquid catalase
GB736242A (en) Steroids
GB712948A (en) 21-steroid ester and compositions thereof
GB563991A (en) Improvements in or relating to the production of polyvinyl compounds
GB915578A (en) Process for the production of esters of sugars, hexitols and anhydro-sugars