GB610731A - Improvements in or relating to the purification of penicillin salts - Google Patents
Improvements in or relating to the purification of penicillin saltsInfo
- Publication number
- GB610731A GB610731A GB420246A GB420246A GB610731A GB 610731 A GB610731 A GB 610731A GB 420246 A GB420246 A GB 420246A GB 420246 A GB420246 A GB 420246A GB 610731 A GB610731 A GB 610731A
- Authority
- GB
- United Kingdom
- Prior art keywords
- penicillin
- salt
- cyclohexylamine
- primary amine
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
In an improved process for the preparation of primary amine salts of penicillin, an aqueous solution of a metallic salt of penicillin is treated directly with a salt of a compound of the formula RNH2, where R is a cyclohexyl residue which may contain alkyl substituents containing less than 9 carbon atoms and which compound has a pKH value of not less than 10.2. Preferably, the cooled aqueous solution of the penicillin metallic salt, containing a high concentration of a salting out substance, e.g. sodium chloride, sodium sulphate or potassium chloride, is agitated with a salt of the primary amine causing the primary amine salt of penicillin to separate. Suitable salts of primary amines are those formed with strong mineral acids, specifically such salts of cyclohexylamine and 2-, 3- or 4-methyl cyclohexylamine. In examples: (I) and (III) cyclohexylamine hydrochloride of sodium penicillin react to give cyclohexylamine penicillin, and (II) methyl cyclohexylamine reacts with penicillin to give the methyl cyclohexylamine salt of penicillin. The Provisional Specification includes also the use of additional primary amine salts. Specification 606,482 is referred to.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB420246A GB610731A (en) | 1946-02-11 | 1946-02-11 | Improvements in or relating to the purification of penicillin salts |
| ES0176753A ES176753A1 (en) | 1946-02-11 | 1947-02-10 | A PROCEDURE FOR PURIFYING PENICILLIN SALTS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB420246A GB610731A (en) | 1946-02-11 | 1946-02-11 | Improvements in or relating to the purification of penicillin salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB610731A true GB610731A (en) | 1948-10-20 |
Family
ID=9772641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB420246A Expired GB610731A (en) | 1946-02-11 | 1946-02-11 | Improvements in or relating to the purification of penicillin salts |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES176753A1 (en) |
| GB (1) | GB610731A (en) |
-
1946
- 1946-02-11 GB GB420246A patent/GB610731A/en not_active Expired
-
1947
- 1947-02-10 ES ES0176753A patent/ES176753A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES176753A1 (en) | 1947-03-16 |
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