ES273187A1 - Procedure for the preparation of derivatives of 3,4-dihidroquinazolona (4) (Machine-translation by Google Translate, not legally binding)
- Google Patents
Procedure for the preparation of derivatives of 3,4-dihidroquinazolona (4) (Machine-translation by Google Translate, not legally binding)
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Merck KGaA
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E Merck AG
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Publication of ES273187A1publicationCriticalpatent/ES273187A1/en
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms
(AREA)
Abstract
Process for the preparation of 3,4-dihydroquinazolone- (4) derivatives of the formula I ** (See formula) ** in which And it means C1 or Br, Z means Cl, Br, OH or OR3, and R3 is an organic radical with a total of 18 carbon atoms at most, which may contain one or more nitrogen and/or oxygen atoms in any bonding form, while the group OR3 designates, preferably, ester or carbamate radicals, characterized by the fact that: a) an N-acylanthranilic acid derivative of the formula II is condensed ** (See formula) ** or a derivative, substituted in position 2, of the 3,1-benzoxazin-4-one of the formula III ** (See formula) ** wherein Z has the expressed meaning, with an aromatic amine of formula IV ** (See formula) ** where Y has the meaning already expressed, O well b) an anthranilic acid or o-nitrobenzoic acid derivative of the general formula is condensed ** (See formula) ** in which R4 is equivalent to a hydrocarbon radical or a monovalent inorganic cation, preferably Na, K o NH4, y R 5 is NH 2 or NO 2, with an imide chloride, substituted in N, of formula VI ** (See formula) ** in which Y and Z have the meaning already expressed, and, provided that R5 is NO2, the reaction product is then treated with sodium dithionite, or d) a radical Z is transformed, by methods already known, into another radical 2, and likewise, eventually, e) a compound of the formula I is converted, by already customary processes, into its acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES0273187A1960-12-231961-12-22Procedure for the preparation of derivatives of 3,4-dihidroquinazolona (4) (Machine-translation by Google Translate, not legally binding)
ExpiredES273187A1
(en)
Chemical compounds process for preparing said compounds and process for preparing 6-(p-hydroxyphenyl-glycylamido)-penam or 7-(p-hydroxyphenyl-glycylamido)-cephem compounds