GB563936A - Method for the production of easily soluble chemico-therapeutics of the sulphonamide group - Google Patents
Method for the production of easily soluble chemico-therapeutics of the sulphonamide groupInfo
- Publication number
- GB563936A GB563936A GB1590742A GB1590742A GB563936A GB 563936 A GB563936 A GB 563936A GB 1590742 A GB1590742 A GB 1590742A GB 1590742 A GB1590742 A GB 1590742A GB 563936 A GB563936 A GB 563936A
- Authority
- GB
- United Kingdom
- Prior art keywords
- solution
- added
- sulphanilamido
- thiodiazole
- ammonia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Easily soluble therapeutic compounds are prepared by reacting a 2 - sulphanilamido-1 : 3 : 4-thiodiazole which is substituted in the 5-position by an alkyl or an aryl group, with ammonia or an aliphatic amine. The amount of ammonia or amine added is preferably such as to bring the pH of the resulting solution in the range 7.0-7.4. The concentration of the solution is preferably arranged such that the resulting solution is of about 4 per cent strength in which case it is suitable for application to the eye or to mucous membranes. If a more dilute solution than 4 per cent is used, an addition of neutral salts may be made to bring the total concentration of salts to the point where the solution is isotonic with body fluids. In examples: (1) To 2-sulphanilamido-5-methyl-1 : 3 : 4-thiodiazole (5.5 grams) is added aqueous ammonia to form a solution of pH 7.05. (2) Ammonia is added to the 5-ethyl compound to form a solution of pH 7.2-7.5. (3) Monoethanolamine is added to 2-sulphanilamido-5-methyl-1 : 3 : 4-thiodiazole to form a solution of pH 7.2-7.4. (4) Triethanolamine is added to 2 - sulphanilamido - 5 - methyl - 1 : 3 : 4-thiodiazole to form a solution of pH 7.2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1590742A GB563936A (en) | 1942-11-11 | 1942-11-11 | Method for the production of easily soluble chemico-therapeutics of the sulphonamide group |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1590742A GB563936A (en) | 1942-11-11 | 1942-11-11 | Method for the production of easily soluble chemico-therapeutics of the sulphonamide group |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB563936A true GB563936A (en) | 1944-09-06 |
Family
ID=10067695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1590742A Expired GB563936A (en) | 1942-11-11 | 1942-11-11 | Method for the production of easily soluble chemico-therapeutics of the sulphonamide group |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB563936A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2578761A (en) * | 1950-02-07 | 1951-12-18 | Merck & Co Inc | Alkanolamine salts of sulfaquinoxaline |
-
1942
- 1942-11-11 GB GB1590742A patent/GB563936A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2578761A (en) * | 1950-02-07 | 1951-12-18 | Merck & Co Inc | Alkanolamine salts of sulfaquinoxaline |
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