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Expired
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GB1246/37A
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of GB466555ApublicationCriticalpatent/GB466555A/en
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms
(AREA)
Abstract
The isoxazole-carboxylic acids of the parent Specification are converted into their amides using other secondary amines than dialkylamines. Such amines may comprise secondary aromatic amines, compounds having an NH group as part of a heterocyclic ring, and mono-substituted urethanes. The products possess therapeutic properties. According to the examples: (1) 3 : 5-dimethylisoxazole-4-carboxylic acid chloride is treated with monomethylaniline, methylbenzylamine, p-dimethyl-aminophenyl - benzylamine, vinyl diacetonamine, 2 - methylpiperidine, 2 : 6-dimethyl-piperidine and ethylcarbamic acid ethylester; (2) 5-methylisoxazole-3-carboxylic acid chloride is reacted with methylaniline.
GB1246/37A1936-03-201937-01-15Process for the manufacture of amide derivatives of isoxazole carboxylic acids
ExpiredGB466555A
(en)