GB450147A - Lyophilic biologically active substances - Google Patents

Lyophilic biologically active substances

Info

Publication number
GB450147A
GB450147A GB354/35A GB35435A GB450147A GB 450147 A GB450147 A GB 450147A GB 354/35 A GB354/35 A GB 354/35A GB 35435 A GB35435 A GB 35435A GB 450147 A GB450147 A GB 450147A
Authority
GB
United Kingdom
Prior art keywords
pict
iii
stopper
sealed
vacuum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB354/35A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sharp and Dohme Inc
Original Assignee
Sharp and Dohme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sharp and Dohme Inc filed Critical Sharp and Dohme Inc
Publication of GB450147A publication Critical patent/GB450147A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum

Abstract

<PICT:0450147/III/1> <PICT:0450147/III/2> <PICT:0450147/III/3> <PICT:0450147/III/4> Biologically active substances, such as sera, converted into a solid form, as described in Specification 450,145, by freezing and evaporation of water at low temperature under a vacuum and without comminution, are so prepared by carrying out these operations in a final container, which is then sealed without destroying the vacuum. Suitable receptacles for the product are provided, as shown in Figs. 1, 3 and 6, with rubber stoppers 3 which may be pierced by a hollow needle for evacuation of air or admission of liquid when it is desired to re-dissolve the contents and these are self sealing so that the vacuum is maintained when the needle is withdrawn. The exhaustion may also be effected through lateral tubes 4 which are then sealed off. In the form shown in Fig. 6 an opening 13 is provided which is closed by a thick rubber ring 14 through which a hollow needle may be inserted. The end of a receptacle remote from the stopper may be sealed by a rubber plug 15 which may be pressed in to eject the p liquid contents through a hypodermic needle inserted into the stopper. In the arrangement shown in Fig. 7 a bottle 1 is provided with a stopper 7 secured by a cap 9 carrying a tube 8 closed by a soft rubber stopper 11 and having a lateral sealable tube 12. Specification 450,146 also is referred to.
GB354/35A 1934-01-31 1935-01-04 Lyophilic biologically active substances Expired GB450147A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US450147XA 1934-01-31 1934-01-31

Publications (1)

Publication Number Publication Date
GB450147A true GB450147A (en) 1936-07-06

Family

ID=21935538

Family Applications (1)

Application Number Title Priority Date Filing Date
GB354/35A Expired GB450147A (en) 1934-01-31 1935-01-04 Lyophilic biologically active substances

Country Status (1)

Country Link
GB (1) GB450147A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2391862A (en) * 2002-08-13 2004-02-18 Shield Medicare Ltd Spray dispenser assembly, vessel and seal means
WO2006045625A1 (en) * 2004-10-27 2006-05-04 Glaxosmithkline Biologicals S.A. Process for preparing a lyophilised material
CN100565062C (en) * 2004-10-27 2009-12-02 防腐技术公司 Be used to prepare the technology of lyophilised material
US7832078B2 (en) 2003-07-08 2010-11-16 Aseptic Technologies S.A. Process and apparatus for producing a vial in a sterile environment
US8002130B2 (en) 2005-05-17 2011-08-23 Aseptic Technologies S.A. Closure system and method of filling a vial

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2391862A (en) * 2002-08-13 2004-02-18 Shield Medicare Ltd Spray dispenser assembly, vessel and seal means
GB2391862B (en) * 2002-08-13 2006-05-10 Shield Medicare Ltd Spray dispenser assembly and vessel therefor
US7832078B2 (en) 2003-07-08 2010-11-16 Aseptic Technologies S.A. Process and apparatus for producing a vial in a sterile environment
WO2006045625A1 (en) * 2004-10-27 2006-05-04 Glaxosmithkline Biologicals S.A. Process for preparing a lyophilised material
JP2008518189A (en) * 2004-10-27 2008-05-29 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Method for producing freeze-dried material
CN100565062C (en) * 2004-10-27 2009-12-02 防腐技术公司 Be used to prepare the technology of lyophilised material
AU2005298861B2 (en) * 2004-10-27 2010-06-17 Aseptic Technologies S.A. Process for preparing a lyophilised material
US8574213B2 (en) 2004-10-27 2013-11-05 Aseptic Technologies S.A. Process for preparing a lyophilized material
US8002130B2 (en) 2005-05-17 2011-08-23 Aseptic Technologies S.A. Closure system and method of filling a vial

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