GB324484A - Manufacture of bromine-substituted aryl-1-thioglycollic acids - Google Patents
Manufacture of bromine-substituted aryl-1-thioglycollic acidsInfo
- Publication number
- GB324484A GB324484A GB3764628A GB3764628A GB324484A GB 324484 A GB324484 A GB 324484A GB 3764628 A GB3764628 A GB 3764628A GB 3764628 A GB3764628 A GB 3764628A GB 324484 A GB324484 A GB 324484A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- thioglycollic
- cyano
- bromine
- methoxybenzene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
324,484. Imray, O. Y., (I. G. Farbenindustrie Akt.-Ges.). Dec. 20, 1928. Brominated 2-carboxyamide and brominated 2- cyano-benzene-1-thioglycollic acids and substitution derivatives thereof are obtained by treating the parent compounds with bromine in the presence of a diluent at a temperature below 30‹ C., with or without a halogen carrying catalyst. In examples (1) 3-methyl-5-chlorbenzene-1-thioglycollic-2-carboxyamide is treated with bromine in the presence of sulphuric acid, both with and without iodine as a catalyst the corresponding 4- brom compound being obtained : (2) 2-cyano-3- methyl-5-chlorbenzene-1-thioglycollic acid is similarly brominated both with and without using mercury as a catalyst, the corresponding 4-brom derivative being obtained : (3) 2-cyano-5-methoxybenzene-1-thioglycollic acid dissolved in sulphuric acid is treated with bromine. Glacial acetic acid, chlorinated hydrocarbons and water are also mentioned as diluents. 2-Cyano-5-methoxyzenzene-1-thioglycollic acid is prepared from p-anisidine by forming the thiazthionium compound by means of sulphur chloride, treating with caustic alkali to obtain the 1-mercapto-2-amino-5-methoxybenzene, and condensing with chloracetic acid to give the corresponding o-aminothioglycollic acid, which, on diazotizing and treating with cuprous cyanide, gives 2-cyano-5-methoxybenzene 1-thioglycollic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3764628A GB324484A (en) | 1928-12-20 | 1928-12-20 | Manufacture of bromine-substituted aryl-1-thioglycollic acids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3764628A GB324484A (en) | 1928-12-20 | 1928-12-20 | Manufacture of bromine-substituted aryl-1-thioglycollic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB324484A true GB324484A (en) | 1930-01-30 |
Family
ID=10397954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3764628A Expired GB324484A (en) | 1928-12-20 | 1928-12-20 | Manufacture of bromine-substituted aryl-1-thioglycollic acids |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB324484A (en) |
-
1928
- 1928-12-20 GB GB3764628A patent/GB324484A/en not_active Expired
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