GB2608698A

GB2608698A - Multi-sample tissue homogenizer

Info

Publication number: GB2608698A
Application number: GB2207642.6A
Authority: GB
Inventors: Li Xiangyao; Sheng Tao; Liu Li; Wu Cheng; Wang Jinghua; Lian Yanna
Original assignee: Zhejiang University ZJU
Current assignee: Zhejiang University ZJU
Priority date: 2021-06-03
Filing date: 2022-05-25
Publication date: 2023-01-11
Anticipated expiration: 2042-05-25
Also published as: GB202207642D0; CN113324825A; GB2608698B

Abstract

A multi-sample tissue homogenizer 100 includes base 10, at least two metal bath assemblies 20 on the base, and homogenizing assemblies 30, and a heat dissipation module 40, each metal bath assembly includes a heat conduction block 21, a heat preservation casing 23 and a refrigeration module 22, the heat preservation casing is arranged outside the heat conduction block, the refrigeration module 22 is arranged between the heat preservation casing and the heat conduction block, a cavity 24 is formed in the heat conduction block 21 and is configured for placing samples therein, part 32 of a homogenizing assembly 30 is arranged in each cavity 24 and is movable in the cavity to homogenise samples. The heat dissipation module 40 is connected with the refrigeration module 22 and used for lowering the temperature of the refrigeration module. The refrigeration module 22 may be a Peltier cooling plate.

Description

MULTI-SAMPLE TISSUE HOMOGENIZER

TECHNICAL FIELD

[0001] The present disclosure relates to the field of homogenizers, and specifically relates to a multi-sample tissue homogenizer.

BACKGROUND ART

[0002] In biological experiments, the content of proteins or nucleic acids in multiple tissue samples needs to be detected at the same time, so that the influence of the experiment on substances to he detected is researched. There occur various errors in scientific experiments, and in order to minimize the influence of the errors on the experiment conclusion, it is necessary to measure multiple samples for each treatment. During the detection process, multiple samples need to be homogenized. At present, existing homogenizers in laboratories can typically only homogenize one sample. While a certain experimental sample is homogenized, other samples have to be placed on ice to remain low temperature. By doing that, the degradation speed of the samples is expected to be reduced through low temperature, so that the states of the samples are kept consistent, and errors are reduced. However, it currently takes a long period of time for the homogenizers in laboratories to process multiple samples, and the samples are easily subject to laboratory temperature, weather conditions, environmental factors and the like, so that the difference among the samples in a group becomes increased, resulting in too large experimental errors.

SUMMARY OF THE INVENTION

[0003] The present. disclosure aims to provide a multi-sample tissue homogenizer to at least solve at least one of the above defects existing in the above prior art.

[0004] In order to solve the defects, according to one aspect of the present disclosure, a multi-sample tissue homogenizer is provided. The multi-sample tissue homogenizer includes a base, at least two metal bath assemblies and homogenizing assemblies, and a heat dissipation module, wherein the metal bath assemblies are installed on the base, and each metal bath assembly includes a heat conduction block, a heat preservation casing and a refrigeration module, the heat preservation casing is arranged outside the heat conduction block, the refrigeration module is arranged between the heat preservation casing and the heat. conduction block, a cavity is formed in the heat conduction block and configured for placing a sample therein, at least a part of a homogenizing assembly is arranged in the cavity and is movable in the cavity, and the heat. dissipation module is connected with the refrigeration module and is configured for lowering the temperature of the refrigeration module.

[0005] In one embodiment, the refrigeration module includes a semiconductor heat radiation fin, the semiconductor heat radiation fin is provided with a first surface and a second surface opposite to the first surface, the first surface is in direct or indirect contact with the heat conduction block, and the second surface cooperates with the refrigeration module.

[0006] In one embodiment, the multi-sample tissue homogenizer further includes a temperature measurement module, and the temperature measurement module cooperates with the heat conduction block to measure the temperature of the heat conduction block. [0007] In one embodiment, the multi-sample tissue homogenizer further includes a control module, and the control module is connected with the refrigeration module, the homogenizing assemblies, the heat dissipation module and the temperature measurement module, and controls the operations of the refrigeration module, the homogenizing assemblies, the heat dissipation module and the temperature measurement module. [0008] In one embodiment, the heat dissipation module includes a heat conductor, a liquid guide pipe and a cold radiator, the heat conductor is arranged on the second surface of the semiconductor heat radiation fin, and the cold radiator is in fluid communication with the heat conductor through the liquid guide pipe so as to cool the heat conductor. [0009] In one embodiment, the heat dissipation module further includes a fan, and the fan is installed at one side of the cold radiator to carry out heat dissipation on the cold radiator.

[0010] In one embodiment, the base includes an upper base and a lower base, the homogenizing assemblies are arranged in the upper base, and the metal bath assemblies arc arranged in the lower base.

[0011] In one embodiment, the base further includes a stand, and the upper base and the lower base are connected with each other through the stand.

[0012] In one embodiment, each of the homogenizing assemblies includes a motor and a homogenizing component, the homogenizing component extends into the cavity of the heat conduction block, and the motor is connected with the homogenizing component and drives the homogenizing component to move in the cavity.

[0013] In one embodiment, the metal bath assemblies are independent from each other, and/or the homogenizing assemblies are independent from each other.

[0014] The multi-sample tissue homogenizer in accordance with the present disclosure at least has one of the following beneficial technical effects.

[0015] Firstly, the temperature is controllable. The refrigeration module and the temperature measurement module are controlled by the control module to form a temperature adjusting loop, so that the temperature of the metal bath can be accurately controlled, and the temperatures of all sample tubes and different batches of experiments can be ensured to be kept consistent.

[0016] Secondly, the homogenizer is convenient, quick and efficient. Through the control module, timing start and stop and speed adjustment of the independent homogenizing assemblies are achieved, the treatment effect can be accelerated, the operation is convenient, and the practicability is high.

[0017] Thirdly, the experimental time is saved. The device can carry out tissue homogenate on multiple groups of multiple samples at the same time in a low-temperature environment, so that the experimental time is saved.

BRIEF DESCRIPTION OF THE DRAWINGS

[0018] FIG. 1 is a schematic perspective structural diagram of a multi-sample tissue homogenizer in an embodiment according to the present disclosure.

DETAILED DESCRIPTION OF THE EMBODIMENTS

[0019] The following detailed description of preferred embodiments of the present disclosure is taken in conjunction with the attached drawings to provide a clearer understanding of the objects, characteristics and advantages of the present disclosure. It will be understood that the embodiments shown in the attached drawings are not intended to limit the scope of the present disclosure, but are merely intended to illustrate the essential spirit of the technical schemes of the present disclosure.

[0020] In the following description, for the purposes of illustrating various disclosed embodiments, certain specific details are set forth in order to provide a thorough understanding of the various disclosed embodiments. However, those skilled in the relevant art will recognize that the embodiments may be practiced without one or more of these specific details. In other instances, well-known devices, structures and techniques associated with this application may not have been shown or described in detail to avoid from unnecessarily obscuring the description of the embodiments.

[0021] Reference throughout this specification to "one embodiment" or "an embodiment" means that a particular feature, structure, or characteristic described in combination with the embodiment is included in at least one embodiment.. Therefore, "in one embodiment" or "in an embodiment" appearing at various places throughout the specification does not necessarily refer to a same embodiment. Furthermore, the particular features, structures or characteristics may be combined in any manner in one or more embodiments.

[0022] In the following description, in order to clearly show the structure and operating way of the present disclosure, the description will be made with the help of numerous spatially relative words, but the words "front", "rear", left", "right", "outer", "inner", "outward", "inward", "upper", "lower" and the like should be understood as terms of convenience and not as limiting words.

[0023] The present disclosure generally relates to a device which can be temperature-controllable, simple and convenient, quickly operated and efficient, and capable of carrying out tissue homogenate on multiple groups of multiple samples at the same time.

[0024] A multi-sample tissue homogenizer in accordance with an embodiment of the present disclosure includes a base, at least two metal bath assemblies and homogenizing assemblies, and a heat dissipation module, wherein the metal bath assemblies is installed on the base, and each of the metal bath assemblies includes a heat conduction block, a heat preservation casing and a refrigeration module, the heat preservation casing is arranged outside the heat conduction block, the refrigeration module is arranged between the heat preservation casing and the heat conduction block, a cavity is formed in the heat conduction block and configured for placing a sample therein, at least a part of the homogenizing assembly is arranged in the cavity and is movable in the cavity, and the heat dissipation module is connected with the refrigeration module and is configured for lowering the temperature of the refrigeration module.

[0025] When samples need to be subjected to homogenization treatment, the homogenizing assemblies are taken out from the cavities of the heat conduction blocks of the metal bath assemblies, so that the disposable sample tubes can be placed in the cavities of the heat conduction blocks of the metal bath assemblies. After the disposable sample tubes arc placed in the cavities of the heat conduction blocks of the metal bath assemblies, the multi-sample tissue homogenizer is connected with an external power supply. The refrigeration module starts to work, the temperature is lowered, and the low temperature is conducted to the disposable sample tubes through the heat conduction blocks, so that the samples are in a low-temperature state. Meanwhile, the heat preservation casing arranged outside each heat conduction block serves for effectively decreasing heat exchange between the sample tube and the room temperature, so that the refrigeration efficiency of the refrigeration module is improved. Meanwhile, the heat dissipation module connected with the refrigeration module also works to lower the temperature of the refrigeration module, so that the refrigeration effect of the refrigeration module is more remarkable. The metal bath assemblies and the heat dissipation module cooperate with each other, so that the samples are kept at low temperature, and the degradation speed of the samples is reduced. Therefore, the states of the samples arc kept consistent, and the errors are reduced. In addition, the homogenizing assembly is arranged in the cavity of the heat conduction block to move and is configured for homogenizing the samples. The metal bath assemblies, the homogenizing assemblies and the heat dissipation module are all fixedly installed on the base.

[0026] In an embodiment or the present disclosure, the refrigeration module can also he a semiconductor heat radiation fin. When samples need to be subjected to homogenization treatment, the homogenizing assemblies are taken out from the cavities of the heat conduction blocks of the metal bath assemblies, so that the disposable sample tubes can be placed in the cavities of the heat conduction blocks of the metal bath assemblies. After the disposable sample tubes are placed in the cavities of the heat conduction blocks of the metal bath assemblies, the multi-sample tissue homogenizer is connected with an external power supply. The semiconductor heat radiation fin starts to work, the refrigeration end of the semiconductor heat radiation fin is lowered the temperature, and the low temperature is conducted to the disposable sample tubes through the heat conduction blocks, so that the samples are in a low-temperature state. Meanwhile, the heat preservation casing arranged outside the heat conduction block serves for effectively decreasing heat exchange between the sample tube and the room temperature, so that the refrigeration efficiency of the refrigeration module is improved. Meanwhile, the heat dissipation module connected with the heating end of the semiconductor heat radiation fin also works to lower the temperature of the heating end of the semiconductor heat radiation fin, so that the refrigeration effect of the refrigeration end of the semiconductor heat radiation fin is more remarkable. The metal bath assemblies and the heat dissipation module cooperate with each other, so that the samples are kept at low temperature, and the degradation speed of the samples is reduced. Therefore, the states of the samples are kept consistent, and the errors are reduced. In addition, the homogenizing assembly is arranged in the cavity of the heat conduction block to move and is configured for homogenizing the samples. The metal bath assemblies, the homogenizing assemblies and the heat dissipation module are all fixedly installed on the base.

[0027] In an embodiment of the present disclosure, the multi-sample tissue homogenizer further includes a temperature measurement module, and the temperature measurement module is in contact with the heat conduction block to measure the temperature of the heat conduction block. When samples need to be subjected to homogenization treatment, the homogenizing assemblies are taken out from the cavities of the heat conduction blocks of the metal bath assemblies, so that the disposable sample tubes can be placed in the cavities of the heat conduction blocks of the metal bath assemblies. After the disposable sample tubes arc placed in the cavities of the heat conduction blocks of the metal bath assemblies, the multi-sample tissue homogenizer is connected with an external power supply. The refrigeration module starts to work, the temperature is lowered, and the low temperature is conducted to the disposable sample tubes through the heat conduction blocks, so that the samples are in a low-temperature state. Meanwhile, the heat preservation casing arranged outside each heat conduction block serves for effectively decreasing heat exchange between the sample tube and the room temperature, so that the refrigeration efficiency of the refrigeration module is improved. Meanwhile, the heat dissipation module connected with the refrigeration module also works to lower the temperature of the refrigeration module, so that the refrigeration effect of the refrigeration module is more remarkable. The temperature measurement module in contact with the heat conduction block measures the temperature of the heat conduction block during the working process of the multi-sample tissue homogenizer. The metal bath assemblies and the heat dissipation module cooperate with each other, so that the samples are kept at low temperature, and the degradation speed of the samples is reduced. Therefore, the states of the samples arc kept consistent, and the errors are reduced. In addition, the homogenizing assembly is arranged in the cavity of the heat conduction block to move and is configured for homogenizing the samples.

[0028] In an embodiment of the present disclosure, the multi-sample tissue homogenizer further includes a control module, and the control module is in signal communication with the refrigeration module, the homogenizing assemblies, the heat dissipation module and the temperature measurement module, and the control module controls the operations of the refrigeration module, the homogenizing assemblies, the heat dissipation module and the temperature measurement module. When samples need to be subject to homogenization treatment, the homogenizing assemblies are taken out from the cavities of the heat conduction blocks of the metal bath assemblies, so that the disposable sample tubes can be placed in the cavities of the heat conduction blocks of the metal bath assemblies. After the disposable sample tubes arc placed in the cavities of the heat conduction blocks of the metal bath assemblies, the multi-sample tissue homogenizer is connected with an external power supply. The refrigeration module starts to work, the temperature is lowered, and the low temperature is conducted to the disposable sample tubes through the heat conduction blocks, so that the samples are in a low-temperature state. The temperature measurement module in contact with the heat conduction block starts to work. When the temperature measurement module measures that the temperature of the heat conduction block is higher than the required temperature, the temperature measurement module transmits information to the refrigeration module through the control module, so that the refrigeration module is controlled to start refrigeration, meanwhile, the control module transmits signals to the heat dissipation module to control the heat dissipation module to coordinate with the refrigeration module, so that the refrigeration efficiency of the refrigeration module is higher; and when the temperature measurement module measures that the temperature of the heat conduction block is lower than the required temperature, the temperature measurement module transmits information to the refrigeration module through the control module, so that the refrigeration module is controlled to stop refrigeration, meanwhile, the control module transmits signals to the heat dissipation module to control the heat dissipation module to stop heat dissipation. Temperature measurement and temperature control are achieved through the control module, and the temperature of the samples is stabilized. In addition, the control module controls the homogenizing assemblies to move in the cavities of the heat conduction blocks to homogenize the samples. Due to the fact that the multi-sample tissue homogenizer includes at least two metal bath assemblies, the refrigeration module and the temperature measurement module are controlled through a circuit to form a temperature adjusting loop, the temperature of each metal bath is adjusted and stabilized, and the cavity is preserved in the metal bath assembly according to the dimensions and specifications of the disposable sample tubes, so that the temperatures of all sample tubes and different batches of experiments can be ensured to be kept consistent. In addition, the motor is controlled through a circuit, and timing start and stop and speed adjustment of the homogenate rod can be achieved, so that the treatment effect can be accelerated, and the operation is convenient.

[0029] In an embodiment of the present disclosure, the heat dissipation module of the multi-sample tissue homogenizer includes a heat conductor, a liquid guide pipe and a cold radiator. When samples need to be subject to homogenization treatment, the homogenizing assemblies are taken out from the cavities of the heat conduction blocks of the metal bath assemblies, so that the disposable sample tubes can he placed in the cavities of the heat conduction blocks of the metal bath assemblies. After the disposable sample tubes are placed in the cavities of the heat conduction blocks of the metal bath assemblies, the multi-sample tissue homogenizer is connected with an external power supply. The refrigeration module starts to work, the temperature is lowered, and the low temperature is conducted to the disposable sample tubes through the heat conduction blocks, so that the samples are in a low-temperature state. Meanwhile, the heat preservation casing arranged outside each heat conduction block serves for effectively decreasing heat exchange between the sample tube and the room temperature, so that the refrigeration efficiency of the refrigeration module is improved. Meanwhile, the cold radiator cools liquid transmitted from the heat conductor through the liquid guide pipe, so that the refrigeration effect of the refrigeration module is more remarkable. The metal bath assemblies and the heat dissipation module cooperate with each other, so that the samples are kept at low temperature, and the degradation speed of the samples is reduced. Therefore, the states of the samples are kept consistent, and the errors are reduced.

[0030] In an embodiment of the present disclosure, the heat dissipation module of the multi-sample tissue homogenizer further includes a fan. When samples need to be subjected to homogenization treatment, the homogenizing assemblies are taken out from the cavities of the heat conduction blocks of the metal bath assemblies, so that the disposable sample tubes can he placed in the cavities of the heat conduction blocks of the metal bath assemblies. After the disposable sample tubes are placed in the cavities of the heat conduction blocks of the metal bath assemblies, the multi-sample tissue homogenizer is connected with an external power supply. The refrigeration module starts to work, the temperature is lowered, and the low temperature is conducted to the disposable sample tubes through the heat conduction blocks, so that the samples are in a low-temperature state. Meanwhile, the heat preservation casing arranged outside each heat conduction block serves for effectively decreasing heat exchange between the sample tube and the room temperature, so that the refrigeration efficiency of the refrigeration module is improved. Meanwhile, the cold radiator cools liquid transmitted from the heat conductor through the liquid guide pipe, and the fan further quickly cools liquid transmitted from the heat conductor through the liquid guide pipe, so that the refrigeration effect of the refrigeration module is more remarkable. The metal bath assemblies and the heat dissipation module cooperate with each other, so that the samples are kept at low temperature, and the degradation speed of the samples is reduced. Therefore, the states of the samples arc kept consistent, and the errors arc reduced. In addition, each homogenizing assembly is arranged in the cavity of the heat conduction block to move and is used for homogenizing the samples. The metal bath assemblies, the homogenizing assemblies and the heat dissipation module are all fixedly installed on the base.

[0031] In an embodiment of the present disclosure, the base of the multi-sample tissue homogenizer includes an upper base and a lower base. The upper base and the lower base can be joined into a whole to fixedly install the metal bath assemblies, the homogenizing assemblies and the heat dissipation module, meanwhile, The upper base and the lower base can be separated from each other, so that the metal bath assemblies can be separated from the homogenizing assemblies, and a space for placing the disposable sample tube can be left by the metal bath assemblies. Optionally, the upper base and the lower base arc provided with cavities, and the metal bath assemblies, the homogenizing assemblies and the heat dissipation module can all be fixed in the cavities; or, the lower base is provided with a cavity so that the metal bath assemblies can be fixedly installed in the cavity of the lower base, the upper base is only a flat plate perpendicular to the side wall of the lower base, and the flat plate can be inserted into the side wall of the lower base and fixed to the side wall of the lower base, while the homogenizing assemblies are fixedly installed on the flat plate. In addition, other forms of the upper base and the lower base are available to enable fixedly installing the metal bath assemblies, the homogenizing assemblies and the heat dissipation module.

[0032] In an embodiment of the present disclosure, the homogenizing assemblies of the multi-sample tissue homogenizer arc fixedly installed on the upper base. The homogenizing assemblies are fixedly installed on the upper base and are positioned directly above the metal bath assemblies aligned horizontally, so that each homogenizing assembly can move in the cavity of the respective heat conduction block of the respective metal bath assembly to homogenize the sample.

[0033] In an embodiment of the present disclosure, the metal bath assemblies of the multi-sample tissue homogenizer are independent from each other, and the homogenizing assemblies are independent from each other, so that during the operational process of the multi-sample tissue homogenizer, homogenization of each sample can he carried out independently. For example, homogenization can be carried out on multiple sample tubes at the same time; only one sample tube can be placed to homogenize one sample; and one part of the samples can be homogenized, and other part of the samples are refrigerated. Besides, the samples can be homogenized only, or the samples can be refrigerated only. Different samples are homogenized and refrigerated according to different requirements. so that energy is saved.

[0034] An embodiment of a multi-sample tissue homogenizer in accordance with the present disclosure is described below with reference to FIG. 1.

[0035] FIG. 1 is a schematic perspective structural diagram of a multi-sample tissue homogenizer 100 in an embodiment of the present disclosure. As shown in FIG. 1, the multi-sample tiss ue homogenizer 100 includes abase 10, six metal bath assemblies 20, six homogenizing assemblies 30, a heat dissipation module 40, a temperature measurement module 50 and a control module 60. The base 10 is composed of an upper base 11, a stand 12 and a lower base 13 from top to bottom in the vertical direction. The upper base 11 and the lower base 13 each are of a quadrilateral frame plate structure. The upper base 11 and the lower base 13 are spaced apart at a certain distance in the vertical direction. The upper base 11 and the lower base 13 are oppositely provided with cavities, so that there is an accommodation space below the upper base 11 in the vertical direction and above the lower base 13 in the vertical direction. The stand 12 is perpendicularly fixed to the lower base 13 and connected with the upper base 11 and supports the upper base 11, so that the upper base 11, the stand 12 and the lower base 13 are fixed to each other and form an integral support which can he carried freely. Optionally, the upper base 11 can he detached from the integral structure composed of the upper base 11 with the lower base 13 and the stand 12 in order to allow the space for cavities 24 of heat conduction blocks 21 in the metal bath assemblies 20, facilitating to place sample tubes in the cavities 24. After the sample tubes have been placed, the upper base 11 still can be installed on the stand 12. At this time, the upper base 11, the stand 12 and the lower base 13 are fixed to each other and form an integral support.

[0036] Although in the embodiment shown in FIG. 1, the multi-sample tissue homogenizer 100 includes six metal bath assemblies 20, six homogenizing assemblies 30, a heat dissipation module 40, a temperature measurement module 50 and a control module 60, in other embodiments, the multi-sample tissue homogenizer 100 can also include more than or less than six metal bath assemblies 20, such as two or three metal bath assemblies 20, and can also include more than or less than six homogenizing assemblies 30, such as two or three homogenizing assemblies 30. Furthermore, in other embodiments, multiple heat dissipation modules 40, multiple temperature measurement modules 50, multiple control modules 60 and the like can also be included.

[0037] The metal bath assemblies 20 each include a heat conduction block 21, a semiconductor heat radiation fin 22, and a heat preservation casing 23. The heat conduction block 21 is provided with a cavity 24 for placing the sample tube (not shown) therein. The heat preservation casing 23 is arranged outside the heat conduction block 21, and used for reducing heat exchange between the sample tube placed in the cavity 24 and the room temperature. The semiconductor heat radiation fin 22 is arranged between the heat preservation casing 23 and the heat conduction block 21. The semiconductor heat radiation fin in the present disclosure is also called as a semiconductor chilling plate, and further also called as a thermoelectric chilling plate, which utilizes the Peltier effect of semiconductor materials, that is, when direct current passes through a galvanic couple formed by connecting two different semiconductor materials in series, both ends of the galvanic couple can absorb and release heat respectively, so that the purpose of refrigeration can be achieved. The refrigeration end of the semiconductor heat radiation fin 22 cooperates with the heat conduction block 21, so that low temperature can be transmitted to the sample tube placed in the cavity 24 through the heat conduction block 21, and while the heating end of the semiconductor heat radiation fin 22 cooperates with the heat dissipation module 40, so that heat can be taken away through the heat dissipation module 40. Optionally, the six metal bath assemblies 20 in FIG. 1 are independent from each other, and fixedly installed on the lower base 13.

[0038] In one embodiment, the heat dissipation module 40 includes a heat conductor 41, a liquid guide pipe 42, a cold radiator 43 and a fan 44. The heat conductor 41 is in contact connection with a heating end of the semiconductor heat radiation fin 22, the cold radiator 43 is in fluid communication with a water-cooled heat conduction block 41 through the liquid guide pipe 42. The cold radiator 43 and the fan 44 are both embedded on the side wall of the lower base 13, and further the cold radiator 43 is installed on the inner side of the cavity of the lower base 13, and the fan 44 is installed on the outer side of the cavity of the lower base 13. The cold radiator 43 cools the liquid transmitted from the heat conductor 41 through the liquid guide pipe 42, and the fan 44 further cools the liquid transmitted from the heat conductor 41 through the liquid guide pipe 42 in an accelerated mode. Optionally, the six metal bath assemblies 20 are respectively provided with heat conductors 41, and each of the six heat conductors 41 is connected to a cold radiator 43 and a fan 44 through the liquid guide pipe 42. Optionally, the heat conductor 41 is a water-cooled heat conduction block, and the liquid flowing in the liquid guide pipe 42 is water. The heat. conductor 41 further can also adopt a metal heat conduction block.

[0039] It is to be noted that the above heat dissipation module 40 including heat conductors 41, the liquid guide pipe 42, the cold radiator 43 and the fan 44 is merely an optional implementation of the heat dissipation module 40, and in other embodiments, the heat dissipation module 40 can be implemented in other ways, for example, the heat dissipation module 40 may not include the fan 44.

[0040] With further reference to FIG. 1, the homogenizing assemblies 30 according to one embodiment of the present disclosure are described. Each homogenizing assembly 30 includes a homogenizing component 32, and the homogenizing component 32 extends into the cavity 24 of the heat conduction block 21 to stir and homogenize the samples in the cavity 24. Optionally the homogenizing assembly 30 can further include a control motor 31, so as to control movement of the homogenizing component 32 manually or in other ways, and the homogenizing component 32 is connected with the control motor 31, in order that the movement of the homogenizing component 30 can be controlled through the control motor 31. In the embodiment shown in FIG. 1, the control motor 31 and the homogenizing assembly 30 are fixedly installed on the upper base 11, and a rotating shall of the control motor 31 is connected with the homogenizing component 32. The homogenizing component 32 can he in a rod shape, a spiral shape, a rotary knife shape and other shapes capable of achieving homogenate.

[0041] In one embodiment of the present disclosure, the multi-sample tissue homogenizer 100 can further include a temperature measurement module 50 and a control module 60. The temperature measurement. module 50 is in signal communication with the control module 60 and is in contact with the heat conduction block 21 to measure the temperature of the heat conduction block 21 and transmit the temperature to the control module 60 to realize temperature control. For example, a temperature adjusting loop is formed by a refrigeration module and the temperature measurement module 50, and the control module 60 adjusts and stabilizes the temperature of each metal bath. For example, the control module 60 can be installed on the upper base 11, and is optionally in signal communication with the homogenizing assembly 30, the heat dissipation module 40 and the temperature measurement module 50 to control the operation of the homogenizing assembly 30, the heat dissipation module 40 and the temperature measurement module 50. The temperature measurement module 50 may be implemented by way of a resistance thermometer, a pressure thermometer or the like.

[0042] When samples need to be homogenized, the sample tube is placed in the cavity 24 of the heat conduction block 21, and a power supply is switched on, and then the homogenizing assembly 30, the heat dissipation module 40 and the temperature measurement module 50 start to work to stir and homogenize the samples. Wherein, the temperature measurement module 50 transmits temperature information of the heat conduction block 21 to the control module 60, and the control module 60 compares the temperature with a preset temperature. If the temperature is higher than the preset temperature, the control module 60 controls the heat dissipation module 40 to work, the cold radiator 43 cools liquid transmitted from the heat conductor 41 in contact with the semiconductor heat radiation fin 22 through the liquid guide pipe 42, and the fan 44 further accelerates cooling of the liquid from the heat conductor 41 through the liquid guide pipe 42, in order to enhance the heat dissipation effect of the cold radiator 43. The control module 60 can also adjust the speed of the homogenizing motor 31 and control the timing start and stop of the homogenizing motor according to the received information.

[0043] As shown in FIG. 1, since the six metal bath assemblies 20 in the multi-sample tissue homogenizer 100 are all independently connected and the six homogenizing assemblies 30 are also independently connected, the multi-sample tissue homogenizer 100 shown in FIG. 1 can carry out timing start and stop and speed adjustment of single or multiple metal bath assemblies 20 and homogenizing assemblies 30 at the same time. [0044] In conclusion, the multi-sample tissue homogenizer in accordance with the present disclosure has the beneficial advantages of being controllable in temperature, simple and convenient, efficient and quick, capable of saving experimental time, capable of homogenize multiple groups of tissues at the same time and the like.

[0045] According to the present disclosure, each independent low-temperature metal bath can be independently controlled through the circuit, multiple samples can be homogenized at the same time, so that the existing defect that the homogenizer in the laboratory can only homogenize one sample can he solved, and furthermore by controlling the independent homogenizing assemblies through the control module, the problems, for example the sample homogenization time period is too long, can he solved. Compared with domestic similar research and product achievements, the low-temperature multi-sample tissue homogenizer in accordance with the present disclosure has at least beneficial technical effects as follows.

[0046] Firstly, the temperature is controllable. The refrigeration module and the temperature measurement module arc controlled by the control module to form a temperature adjusting loop, so that the temperature of the separate low-temperature metal bath can be accurately controlled, and the temperatures of all sample tubes and different hatches of experiments can be ensured to he kept consistent.

[0047] Secondly, the homogenizer is convenient, quick and efficient. Through controlling the motor by the control module, timing start and stop and speed adjustment of the independent homogenizing assemblies are achieved, the treatment effect can be accelerated, the operation is convenient, and the practicability is high.

[0048] Thirdly, the experimental time is saved. The device can carry out tissue homogenate on multiple groups of multiple samples at the same time in a low-temperature environment, so that the experimental time is saved.

[0049] The above preferred embodiments of the present disclosure are described in detail, but it should be understood that various changes or modifications of the present disclosure may occur to those skilled in the art after reading the above teaching of the present disclosure. Such equivalents are intended to fall within the scope of the present application as defined by the claims appended hereto.

Claims

CLAIMS1. A multi-sample tissue homogenizer, comprising a base, at least two metal bath assemblies and homogenizing assemblies, and a heat dissipation module, wherein the metal bath assemblies are installed on the base, and each metal bath assembly comprises a heat conduction block, a heat preservation casing and a refrigeration module, the heat preservation casing is arranged outside the heat conduction block, the refrigeration module is arranged between the heat preservation casing and the heat conduction block, a cavity is formed in the heat conduction block and configured for placing a sample therein, at least a pail of a homogenizing assembly is arranged in the cavity and is movable in the cavity, and the heat dissipation module is connected with the refrigeration module and is configured for lowering the temperature of the refrigeration module.
2. The multi-sample tissue homogenizer according to claim 1, wherein the refrigeration module comprises a semiconductor heat radiation fin, the semiconductor heat radiation fin is provided with a first surface and a second surface opposite to the first surface, the first surface is in direct or indirect contact with the heat conduction block, and the second surface cooperates with the heat dissipation module.
3. The multi-sample tissue homogenizer according to claim 1, wherein the multi-sample tissue homogenizer further comprises a temperature measurement module, and the temperature measurement module cooperates with the heat conduction block to measure the temperature of the heat conduction block.
4. The multi-sample tissue homogenizer according to claim 3, wherein the multi-sample tissue homogenizer further comprises a control module, and the control module is connected with the refrigeration module, the homogenizing assemblies, the heat dissipation module and the temperature measurement module, and controls the operations of the refrigeration module, the homogenizing assemblies, the heat dissipation module and the temperature measurement. module.
5. The multi-sample tissue homogenizer according to claim 2, wherein the heat dissipation module comprises a heat conductor, a liquid guide pipe and a cold radiator, the heat conductor is arranged on the second surface of the semiconductor heat radiation fin, and the cold radiator is in fluid communication with the heat conductor through the liquid guide pipe so as to cool the heat conductor.
6. The multi-sample tissue homogenizer according to claim 5, wherein the heat dissipation module further comprises a fan, and the fan is installed at one side of the cold radiator to carry out heat dissipation on the cold radiator.
7. The multi-sample tissue homogenizer according to claim 1, wherein the base comprises an upper base and a lower base, the homogenizing assemblies are arranged in the upper base, and the metal bath assemblies are arranged in the lower base.
8. The multi-sample tissue homogenizer according to claim 7, wherein the base further comprises a stand, and the upper base and the lower base are connected with each other through the stand.
9. The multi-sample tissue homogenizer according to claim 1, wherein each of the homogenizing assemblies comprises a motor and a homogenizing component, the homogenizing component extends into the cavity of the heat conduction block, and the motor is connected with the homogenizing component and drives the homogenizing component to move in the cavity.
10. The multi-sample tissue homogenizer according to claim 1 wherein the metal bath assemblies arc independent from each other, and/or the homogenizing assemblies are independent from each other.