GB2458863B - Improved culture of stem cells - Google Patents
Improved culture of stem cellsInfo
- Publication number
- GB2458863B GB2458863B GB0914193A GB0914193A GB2458863B GB 2458863 B GB2458863 B GB 2458863B GB 0914193 A GB0914193 A GB 0914193A GB 0914193 A GB0914193 A GB 0914193A GB 2458863 B GB2458863 B GB 2458863B
- Authority
- GB
- United Kingdom
- Prior art keywords
- stem cells
- improved culture
- culture
- improved
- stem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000000130 stem cell Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Gynecology & Obstetrics (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Developmental Biology & Embryology (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Reproductive Health (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88074707P | 2007-01-17 | 2007-01-17 | |
| PCT/US2008/051347 WO2008089351A1 (en) | 2007-01-17 | 2008-01-17 | Improved culture of stem cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB0914193D0 GB0914193D0 (en) | 2009-09-16 |
| GB2458863A GB2458863A (en) | 2009-10-07 |
| GB2458863B true GB2458863B (en) | 2011-10-12 |
Family
ID=39277243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB0914193A Active GB2458863B (en) | 2007-01-17 | 2008-01-17 | Improved culture of stem cells |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7892830B2 (enExample) |
| JP (1) | JP5419279B2 (enExample) |
| CA (1) | CA2675445C (enExample) |
| GB (1) | GB2458863B (enExample) |
| SE (1) | SE0950586L (enExample) |
| WO (1) | WO2008089351A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4667241B2 (ja) * | 2003-06-27 | 2011-04-06 | 旭化成株式会社 | 細胞分化抑制剤、これを用いた細胞培養方法、培養液及び培養された細胞株 |
| EP1962719A4 (en) | 2005-08-29 | 2011-05-04 | Technion Res And Dev Of Foundation Ltd | MEDIA FOR BREEDING STEM CELLS |
| US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
| US20090227032A1 (en) * | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| KR101420740B1 (ko) * | 2005-12-13 | 2014-07-17 | 교또 다이가꾸 | 핵초기화 인자 |
| US8278104B2 (en) * | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| DK3441459T3 (da) | 2006-08-02 | 2021-06-07 | Technion Res & Dev Foundation | Fremgangsmåder til ekspansion af embryonale stamceller i en suspensionskultur |
| JP2008099662A (ja) | 2006-09-22 | 2008-05-01 | Institute Of Physical & Chemical Research | 幹細胞の培養方法 |
| US9213999B2 (en) * | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
| JP2008307007A (ja) * | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| ES2690554T3 (es) | 2008-03-17 | 2018-11-21 | The Scripps Research Institute | Enfoques químicos y genéticos combinados para la generación de células madre pluripotentes inducidas |
| WO2009116840A2 (en) * | 2008-03-21 | 2009-09-24 | Industry-Academic Cooperation Foundation, Yonsei University | Chemical reagents regulating stem cell fate |
| ES2722198T3 (es) | 2008-05-02 | 2019-08-08 | Univ Kyoto | Método de reprogramación nuclear |
| WO2009135206A1 (en) | 2008-05-02 | 2009-11-05 | Stem Cell Products, Inc. | Method for production of mast cells from stem cells |
| US8648170B2 (en) * | 2008-09-19 | 2014-02-11 | Wisconsin Alumni Research Foundation | Peptide-presenting surfaces for long-term culture of pluripotent cells |
| EP3260534A1 (en) * | 2008-11-20 | 2017-12-27 | Janssen Biotech, Inc. | Pluripotent stem cell culture on micro-carriers |
| ES2645869T3 (es) | 2008-12-17 | 2017-12-11 | The Scripps Research Institute | Generación y mantenimiento de células madre |
| US8642334B2 (en) | 2009-02-17 | 2014-02-04 | Memorial Sloan Kettering Cancer Center | Methods of neural conversion of human embryonic stem cells |
| JP6189581B2 (ja) * | 2009-02-20 | 2017-08-30 | セルラー ダイナミクス インターナショナル, インコーポレイテッド | 幹細胞の分化のための方法および組成物 |
| WO2010107392A1 (en) * | 2009-03-20 | 2010-09-23 | Agency For Science, Technology And Research | Culture of pluripotent and multipotent cells on microcarriers |
| US8193235B2 (en) * | 2009-06-12 | 2012-06-05 | University Of Kansas | Compositions and methods for establishing and maintaining stem cells in an undifferentiated state |
| ES2638464T3 (es) * | 2009-10-16 | 2017-10-20 | The Scripps Research Institute | Inducción de células pluripotentes |
| CA2777552C (en) | 2009-10-19 | 2019-05-21 | Cellular Dynamics International, Inc. | Cardiomyocyte production |
| ES2539487T3 (es) * | 2009-11-04 | 2015-07-01 | Cellular Dynamics International, Inc. | Reprogramación episómica con compuestos químicos |
| CN102712896A (zh) * | 2009-11-06 | 2012-10-03 | Rnl生物技术株式会社 | 用于增殖毛囊干细胞的方法 |
| EP2499236B1 (en) | 2009-11-12 | 2020-01-01 | Technion Research & Development Foundation Ltd. | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
| US10947499B2 (en) * | 2009-12-02 | 2021-03-16 | Research Development Foundation | Selection of stem cell clones with defined differentiation capabilities |
| AU2011235212B2 (en) | 2010-03-31 | 2014-07-31 | The Scripps Research Institute | Reprogramming cells |
| EP3399026B1 (en) | 2010-06-14 | 2024-06-26 | The Scripps Research Institute | Reprogramming of cells to a new fate |
| WO2012020845A1 (ja) * | 2010-08-09 | 2012-02-16 | 武田薬品工業株式会社 | 膵ホルモン産生細胞の製造法 |
| EP3056198A2 (en) * | 2010-09-16 | 2016-08-17 | MSP Co., Ltd | Use of compounds for inducing differentiation of mesenchymal stem cells to chondrocytes |
| US9181529B2 (en) | 2010-10-19 | 2015-11-10 | Cellular Dynamics International, Inc. | Titration of differentiation medium components |
| CN106893692B (zh) | 2010-12-22 | 2021-11-26 | 菲特治疗公司 | 用于单细胞分选与增强ipsc重新编程的细胞培养平台 |
| EP2676140A2 (en) * | 2011-02-14 | 2013-12-25 | Life Technologies Corporation | Substrates and methods for staining live cells |
| US9487752B2 (en) | 2011-03-30 | 2016-11-08 | Cellular Dynamics International, Inc. | Priming of pluripotent stem cells for neural differentiation |
| JP2014520551A (ja) | 2011-07-11 | 2014-08-25 | セルラー ダイナミクス インターナショナル, インコーポレイテッド | 細胞のリプログラミング方法およびゲノムの改変方法 |
| CN110684734A (zh) | 2011-11-04 | 2020-01-14 | 纪念斯隆-凯特琳癌症中心 | 用于植入的中脑多巴胺(da)神经元 |
| WO2013082268A1 (en) | 2011-11-30 | 2013-06-06 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for regulation of cell aging, carcinogenesis, and reprogramming |
| US10266807B2 (en) | 2013-04-03 | 2019-04-23 | FUJIFILM Cellular Dynamics, Inc. | Methods and compositions for culturing endoderm progenitor cells in suspension |
| EP3498824A1 (en) | 2013-04-26 | 2019-06-19 | Memorial Sloan-Kettering Cancer Center | Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells |
| SG10201807292YA (en) | 2014-03-04 | 2018-09-27 | Fate Therapeutics Inc | Improved reprogramming methods and cell culture platforms |
| ES2939807T3 (es) | 2014-03-21 | 2023-04-27 | Fujifilm Cellular Dynamics Inc | Producción de neuronas dopaminérgicas del mesencéfalo y métodos para su utilización |
| EP3183338B1 (en) | 2014-08-19 | 2020-03-04 | FUJIFILM Cellular Dynamics, Inc. | Neural networks formed from cells derived from pluripotent stem cells |
| EP3207122B1 (en) | 2014-10-14 | 2019-05-08 | FUJIFILM Cellular Dynamics, Inc. | Generation of keratinocytes from pluripotent stem cells and maintenance of keratinocyte cultures |
| AU2016338680B2 (en) | 2015-10-16 | 2022-11-17 | Fate Therapeutics, Inc. | Platform for the induction and maintenance of ground state pluripotency |
| AU2016341982B2 (en) | 2015-10-21 | 2022-07-07 | Indiana University Research And Technology Corporation | Methods of generating human inner ear sensory epithelia and sensory neurons |
| JP7018875B2 (ja) | 2015-10-21 | 2022-02-14 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション | 多能性幹細胞からのヒト皮膚オルガノイドの誘導 |
| TWI812584B (zh) | 2015-10-30 | 2023-08-21 | 美國加利福尼亞大學董事會 | 從幹細胞產生t細胞之方法及使用該t細胞之免疫療法 |
| EP3438248A4 (en) * | 2016-03-30 | 2019-11-06 | Kyowa Hakko Bio Co., Ltd. | NAIVES PLURIPOTENT STEM CELL CULTIVATION MEDIUM AND PLURIPOTENT STEM CELL CULTIVATION PROCEDURE |
| WO2018035214A1 (en) | 2016-08-16 | 2018-02-22 | Cellular Dynamics International., Inc. | Methods for differentiating pluripotent cells |
| US11767508B2 (en) | 2017-07-24 | 2023-09-26 | Wisconsin Alumni Research Foundation | Methods and culture substrates for controlled induction of biomimetic neural tissues comprising singular rosette structures |
| WO2020047380A1 (en) | 2018-08-31 | 2020-03-05 | Wisconsin Alumni Research Foundation | Generating arterial endothelial cell-seeded vascular grafts |
| US20240219375A1 (en) | 2021-04-07 | 2024-07-04 | FUJIFILM Cellular Dynamics, Inc. | Dopaminergic precursor cells and methods of use |
| CN118339279A (zh) | 2021-10-29 | 2024-07-12 | 富士胶片细胞动力公司 | 包含突变的多巴胺能神经元及其使用方法 |
| WO2025097051A1 (en) | 2023-11-03 | 2025-05-08 | Axent Biosciences Inc. | Thermoreversible polymers with improved stability and methods and uses thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003080649A2 (en) * | 2002-03-20 | 2003-10-02 | Regents Of The University Of Minnesota | Induction of hepatocyte proliferation in vitro by inhibition of cell cycle inhibitors |
| WO2004078917A2 (en) * | 2003-03-07 | 2004-09-16 | Gamida-Cell Ltd. | Expansion of renewable stem cell populations using modulators of pi 3-kinase |
| WO2006020919A2 (en) * | 2004-08-13 | 2006-02-23 | University Of Georgia Research Foundation, Inc. | Compositions and methods for self-renewal and differentiation in human embryonic stem cells |
| WO2008035110A1 (en) * | 2006-09-22 | 2008-03-27 | Riken | Stem cell culture medium and method |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4456757A (en) | 1981-03-20 | 1984-06-26 | Asahi Kasei Kogyo Kabushiki Kaisha | Isoquinolinesulfonyl derivatives and process for the preparation thereof |
| WO1997028130A1 (en) | 1996-02-02 | 1997-08-07 | Nippon Shinyaku Co., Ltd. | Isoquinoline derivatives and drugs |
| ES2286834T5 (es) | 1996-08-12 | 2011-01-31 | Mitsubishi Tanabe Pharma Corporation | Medicamentos que comprenden un inhibidor de la rho quinasa. |
| US7439064B2 (en) | 2000-03-09 | 2008-10-21 | Wicell Research Institute, Inc. | Cultivation of human embryonic stem cells in the absence of feeder cells or without conditioned medium |
| US20020009713A1 (en) * | 2000-05-11 | 2002-01-24 | Miller Freda D. | Methods for identifying modulators of neuronal growth |
| US7829332B2 (en) * | 2004-02-13 | 2010-11-09 | Cornell Research Foundation, Inc. | Purines are self-renewal signals for neural stem cells, and purine receptor antagonists promote neuronal and glial differentiation therefrom |
| JP4576545B2 (ja) * | 2004-05-27 | 2010-11-10 | 独立行政法人理化学研究所 | 羊膜由来因子による胚性幹細胞の培養方法 |
| ES2383813T3 (es) | 2004-09-08 | 2012-06-26 | Wisconsin Alumni Research Foundation | Método de cultivo y cultivo de células madre embrionarias |
| US7442548B2 (en) | 2004-09-08 | 2008-10-28 | Wisconsin Alumni Research Foundation | Culturing human embryonic stem cells in medium containing pipecholic acid and gamma amino butyric acid |
| US7641897B2 (en) * | 2004-11-23 | 2010-01-05 | The Board Of Trustees Of The Leland Stanford Junior University | Feeder layer and serum independent embryonic stem cells |
| ITVA20060041A1 (it) | 2006-07-05 | 2008-01-06 | Dialectica Srl | Uso di composti derivati amminotiazolici, di loro composizioni farmaceutiche, nel trattamento di malattie caratterizzate dalla anormale repressione della trascrizione genica, particolarmente il morbo di huntington |
| CA2658764A1 (en) | 2006-07-20 | 2008-01-24 | Mehmet Kahraman | Benzothiophene inhibitors of rho kinase |
-
2008
- 2008-01-17 JP JP2009546511A patent/JP5419279B2/ja active Active
- 2008-01-17 SE SE0950586A patent/SE0950586L/sv not_active Application Discontinuation
- 2008-01-17 GB GB0914193A patent/GB2458863B/en active Active
- 2008-01-17 CA CA2675445A patent/CA2675445C/en active Active
- 2008-01-17 US US12/016,066 patent/US7892830B2/en active Active
- 2008-01-17 WO PCT/US2008/051347 patent/WO2008089351A1/en not_active Ceased
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003080649A2 (en) * | 2002-03-20 | 2003-10-02 | Regents Of The University Of Minnesota | Induction of hepatocyte proliferation in vitro by inhibition of cell cycle inhibitors |
| WO2004078917A2 (en) * | 2003-03-07 | 2004-09-16 | Gamida-Cell Ltd. | Expansion of renewable stem cell populations using modulators of pi 3-kinase |
| WO2006020919A2 (en) * | 2004-08-13 | 2006-02-23 | University Of Georgia Research Foundation, Inc. | Compositions and methods for self-renewal and differentiation in human embryonic stem cells |
| WO2008035110A1 (en) * | 2006-09-22 | 2008-03-27 | Riken | Stem cell culture medium and method |
Non-Patent Citations (8)
| Title |
|---|
| "Effect of Protein Kinase...", Biotechnology and Applied Biochemistry 12, 1990, 20-27, Posypanova et al. * |
| "Protein kinase C...", Journal of Neurochemistry (1997), 68(2), 564-569, Du et al and CAS-ONLINE abstract accession no 1997:82855. * |
| Curr. Topics Med. Chem., Vol.5, 2005, Ding Sheng, et al., "Small molecules and future...", pp.383-396 * |
| Nature Biotech., Vol.25, 2007, Watanabe, K. et al., "A ROCK inhibitor permits...", pp.681-686 * |
| Neuropharmacol., Vol.52, 2007, Park, et al., "mGluR5 is involved in...", pp.1403-1414 * |
| Neuropsychopharmacol, Vol.31, 2006, Norman, T. R. et al., "Human embryonic stem cells...", pp.2571-2572 * |
| P.N.A.S., Vol.103, 2006, Chen, S. et al., "Self-renewal of embryonic stem cells...", pp.17266-17271 * |
| Stem Cells, Vol.23, 2005, Beattie, G. M. et al., "Activin A maintains...", pp.489-495 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008089351A1 (en) | 2008-07-24 |
| US7892830B2 (en) | 2011-02-22 |
| CA2675445A1 (en) | 2008-07-24 |
| JP5419279B2 (ja) | 2014-02-19 |
| SE0950586L (sv) | 2009-08-13 |
| GB0914193D0 (en) | 2009-09-16 |
| US20080171385A1 (en) | 2008-07-17 |
| JP2010516255A (ja) | 2010-05-20 |
| CA2675445C (en) | 2014-11-04 |
| GB2458863A (en) | 2009-10-07 |
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