GB2454672A - Chromogenic protease substrates - Google Patents

Chromogenic protease substrates Download PDF

Info

Publication number
GB2454672A
GB2454672A GB0722287A GB0722287A GB2454672A GB 2454672 A GB2454672 A GB 2454672A GB 0722287 A GB0722287 A GB 0722287A GB 0722287 A GB0722287 A GB 0722287A GB 2454672 A GB2454672 A GB 2454672A
Authority
GB
United Kingdom
Prior art keywords
polypeptide
amino acid
chromogenic
fragment
protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0722287A
Other languages
English (en)
Other versions
GB0722287D0 (en
Inventor
James Alexander Schouten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mologic Ltd
Original Assignee
Mologic Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mologic Ltd filed Critical Mologic Ltd
Priority to GB0722287A priority Critical patent/GB2454672A/en
Publication of GB0722287D0 publication Critical patent/GB0722287D0/en
Priority to PCT/GB2008/003833 priority patent/WO2009063208A2/en
Priority to JP2010533653A priority patent/JP5667877B2/ja
Priority to EP08849127.9A priority patent/EP2222404B1/en
Priority to AU2008322724A priority patent/AU2008322724B2/en
Priority to NZ585207A priority patent/NZ585207A/en
Priority to CN2008801158369A priority patent/CN101896272B/zh
Priority to CA2705432A priority patent/CA2705432A1/en
Priority to US12/742,867 priority patent/US8993253B2/en
Publication of GB2454672A publication Critical patent/GB2454672A/en
Priority to ZA2010/03313A priority patent/ZA201003313B/en
Priority to IL205699A priority patent/IL205699A0/en
Priority to US14/553,182 priority patent/US9376706B2/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505—Flexible containers without fluid transport within
    • B01L3/5055—Hinged, e.g. opposable surfaces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/583—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with non-fluorescent dye label
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
GB0722287A 2007-11-13 2007-11-13 Chromogenic protease substrates Withdrawn GB2454672A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
GB0722287A GB2454672A (en) 2007-11-13 2007-11-13 Chromogenic protease substrates
US12/742,867 US8993253B2 (en) 2007-11-13 2008-11-13 Protease detection
CN2008801158369A CN101896272B (zh) 2007-11-13 2008-11-13 蛋白酶检测
JP2010533653A JP5667877B2 (ja) 2007-11-13 2008-11-13 プロテアーゼ検出
EP08849127.9A EP2222404B1 (en) 2007-11-13 2008-11-13 Protease detection
AU2008322724A AU2008322724B2 (en) 2007-11-13 2008-11-13 Protease detection
NZ585207A NZ585207A (en) 2007-11-13 2008-11-13 Protease detection using a polypeptide comprising a chromogenic amino acid
PCT/GB2008/003833 WO2009063208A2 (en) 2007-11-13 2008-11-13 Protease detection
CA2705432A CA2705432A1 (en) 2007-11-13 2008-11-13 Protease detection
ZA2010/03313A ZA201003313B (en) 2007-11-13 2010-05-11 Protease detection
IL205699A IL205699A0 (en) 2007-11-13 2010-05-11 Protease detection
US14/553,182 US9376706B2 (en) 2007-11-13 2014-11-25 Protease detection

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0722287A GB2454672A (en) 2007-11-13 2007-11-13 Chromogenic protease substrates

Publications (2)

Publication Number Publication Date
GB0722287D0 GB0722287D0 (en) 2007-12-27
GB2454672A true GB2454672A (en) 2009-05-20

Family

ID=38896238

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0722287A Withdrawn GB2454672A (en) 2007-11-13 2007-11-13 Chromogenic protease substrates

Country Status (11)

Country Link
US (2) US8993253B2 (https=)
EP (1) EP2222404B1 (https=)
JP (1) JP5667877B2 (https=)
CN (1) CN101896272B (https=)
AU (1) AU2008322724B2 (https=)
CA (1) CA2705432A1 (https=)
GB (1) GB2454672A (https=)
IL (1) IL205699A0 (https=)
NZ (1) NZ585207A (https=)
WO (1) WO2009063208A2 (https=)
ZA (1) ZA201003313B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10197571B2 (en) 2012-04-20 2019-02-05 Mologic Limited Enzyme detection device

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2435510A (en) 2006-02-23 2007-08-29 Mologic Ltd Enzyme detection product and methods
CN102176900B (zh) 2008-09-17 2017-09-26 克艾思马有限公司 药物组合物和相关的给药方法
GB201116523D0 (en) 2011-09-23 2011-11-09 Systagenix Wound Man Ip Co Bv Wound prognosis
WO2012104620A2 (en) 2011-01-31 2012-08-09 Systagenix Wound Management Ip Co. B.V. Wound prognosis
US9212386B2 (en) 2011-07-22 2015-12-15 Rapid Pathogen Screening, Inc. Enzymatic cleavage based lateral flow assays
GB201206977D0 (en) 2012-04-20 2012-06-06 Mologic Ltd An enzyme detection device
JP6510747B2 (ja) * 2013-08-02 2019-05-08 東洋ビーネット株式会社 プロテアーゼ活性測定法
HUE071943T2 (hu) 2015-02-03 2025-10-28 Amryt Endo Inc Akromegália kezelése oktreotid orális alkalmazásával
GB201605110D0 (en) 2016-03-24 2016-05-11 Mologic Ltd Detecting sepsis
GB201614053D0 (en) * 2016-08-17 2016-09-28 Microarray Ltd Determining the condition of a wound
GB201902458D0 (en) 2019-02-22 2019-04-10 Mologic Ltd Treatment stratification for an excerbation of inflamation
US11141457B1 (en) 2020-12-28 2021-10-12 Amryt Endo, Inc. Oral octreotide therapy and contraceptive methods

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2185025A (en) * 1986-01-03 1987-07-08 Innofinance Altalanos Innovaci Gonadoliberin derivatives containing an aromatic aminocarboxylic acid in the 6-position, pharmaceutical and veterinary compositions containing them and process for preparing same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5942350A (ja) * 1982-09-01 1984-03-08 Toyo Jozo Co Ltd 新規な合成基質を用いるＬ‐ロイシンアミノペプチダーゼおよびγ‐グルタミルトランスペプチダーゼからなる群より選ばれるペプチダーゼの活性測定法
JPS5988099A (ja) * 1982-11-15 1984-05-21 Toyo Jozo Co Ltd 新規な酵素活性の測定法
US4588836A (en) * 1982-09-01 1986-05-13 Toyo Jozo Kabushiki Kaisha Novel synthetic substrate and assay method using the same
DE3413311A1 (de) * 1984-04-09 1985-10-17 Behringwerke Ag, 3550 Marburg Reagenz zur bestimmung der thromboplastinzeit
GB2435510A (en) * 2006-02-23 2007-08-29 Mologic Ltd Enzyme detection product and methods
GB2435511A (en) * 2006-02-23 2007-08-29 Mologic Ltd Protease detection

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2185025A (en) * 1986-01-03 1987-07-08 Innofinance Altalanos Innovaci Gonadoliberin derivatives containing an aromatic aminocarboxylic acid in the 6-position, pharmaceutical and veterinary compositions containing them and process for preparing same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Anal. Biochem., Vol.254, 1997, Fitzgerald, M. C. et al., "A continuous fluorometric assay...", pp.226-230 *
Anal. Biochem., Vol.293, 2001, Peng, S.-B. et al., "Development of an internally quenched...", pp.88-95 *
Biopolymers, Vol.55, 2000, Ishida, H. et al., "Artificial peptides with unnatural components...", pp.469-278 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10197571B2 (en) 2012-04-20 2019-02-05 Mologic Limited Enzyme detection device

Also Published As

Publication number Publication date
WO2009063208A3 (en) 2009-08-13
GB0722287D0 (en) 2007-12-27
WO2009063208A2 (en) 2009-05-22
CN101896272B (zh) 2013-07-31
IL205699A0 (en) 2010-11-30
CN101896272A (zh) 2010-11-24
EP2222404A2 (en) 2010-09-01
AU2008322724A1 (en) 2009-05-22
US20150152471A1 (en) 2015-06-04
US8993253B2 (en) 2015-03-31
US20110086370A1 (en) 2011-04-14
AU2008322724B2 (en) 2014-03-27
EP2222404B1 (en) 2018-08-01
CA2705432A1 (en) 2009-05-22
US9376706B2 (en) 2016-06-28
JP5667877B2 (ja) 2015-02-12
NZ585207A (en) 2011-09-30
JP2011503160A (ja) 2011-01-27
ZA201003313B (en) 2011-08-31

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