GB2446204A - A Microfluidic device - Google Patents
A Microfluidic device Download PDFInfo
- Publication number
- GB2446204A GB2446204A GB0700653A GB0700653A GB2446204A GB 2446204 A GB2446204 A GB 2446204A GB 0700653 A GB0700653 A GB 0700653A GB 0700653 A GB0700653 A GB 0700653A GB 2446204 A GB2446204 A GB 2446204A
- Authority
- GB
- United Kingdom
- Prior art keywords
- current carrying
- microfluidic
- teeth
- chamber
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/3032—Micromixers using magneto-hydrodynamic [MHD] phenomena to mix or move the fluids
-
- B01F13/0077—
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
- B01F33/452—Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/087—Multiple sequential chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Fluid Mechanics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Electrochemistry (AREA)
- Organic Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Micromachines (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0700653A GB2446204A (en) | 2007-01-12 | 2007-01-12 | A Microfluidic device |
| MX2009007447A MX2009007447A (es) | 2007-01-12 | 2008-01-11 | Dispositivo microfluidico. |
| JP2009545234A JP2010515913A (ja) | 2007-01-12 | 2008-01-11 | マイクロ流体装置 |
| EP08701775A EP2117714A2 (en) | 2007-01-12 | 2008-01-11 | Microfluidic device |
| AU2008204364A AU2008204364A1 (en) | 2007-01-12 | 2008-01-11 | Microfluidic device |
| KR1020097016827A KR20090104102A (ko) | 2007-01-12 | 2008-01-11 | 마이크로유체 장치 |
| CA002675079A CA2675079A1 (en) | 2007-01-12 | 2008-01-11 | Microfluidic device |
| CN200880007915A CN101631616A (zh) | 2007-01-12 | 2008-01-11 | 微流体装置 |
| BRPI0806582-9A BRPI0806582A2 (pt) | 2007-01-12 | 2008-01-11 | Dispositivo microfluídico, sistema lab-on-chip para preparar uma amostra que compreende uma molécula biológica, e, método para o isolamento de um analito. |
| PCT/GB2008/000094 WO2008084245A2 (en) | 2007-01-12 | 2008-01-11 | Microfluidic device |
| US12/442,993 US20100216126A1 (en) | 2007-01-12 | 2008-01-12 | Microfluidic device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0700653A GB2446204A (en) | 2007-01-12 | 2007-01-12 | A Microfluidic device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB0700653D0 GB0700653D0 (en) | 2007-02-21 |
| GB2446204A true GB2446204A (en) | 2008-08-06 |
Family
ID=37809900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB0700653A Withdrawn GB2446204A (en) | 2007-01-12 | 2007-01-12 | A Microfluidic device |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100216126A1 (enExample) |
| EP (1) | EP2117714A2 (enExample) |
| JP (1) | JP2010515913A (enExample) |
| KR (1) | KR20090104102A (enExample) |
| CN (1) | CN101631616A (enExample) |
| AU (1) | AU2008204364A1 (enExample) |
| BR (1) | BRPI0806582A2 (enExample) |
| CA (1) | CA2675079A1 (enExample) |
| GB (1) | GB2446204A (enExample) |
| MX (1) | MX2009007447A (enExample) |
| WO (1) | WO2008084245A2 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2483858A (en) * | 2010-09-21 | 2012-03-28 | Univ Hull | Amplifying nucleic acids using microfluidic device to perform PRC |
| US9101933B2 (en) | 2008-10-10 | 2015-08-11 | University Of Hull | Microfluidic apparatus and method for DNA extraction, amplification and analysis |
| CN107384776A (zh) * | 2017-08-04 | 2017-11-24 | 深圳市合川医疗科技有限公司 | 微流控芯片 |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008003792A1 (de) * | 2008-01-10 | 2009-07-16 | Robert Bosch Gmbh | Verfahren zum Herstellen einer Mikropumpe sowie Mikropumpe |
| ES2835181T3 (es) | 2009-04-27 | 2021-06-22 | El Spectra Llc | Instrumento de pipeta |
| WO2011030272A1 (en) * | 2009-09-11 | 2011-03-17 | Koninklijke Philips Electronics N.V. | Device and method for transporting magnetic or magnetisable beads |
| US20130018256A1 (en) * | 2009-11-25 | 2013-01-17 | Hanoch Kislev | Probing system for measuring the direction and speed of mucus flow in vivo |
| JP5250574B2 (ja) * | 2010-02-10 | 2013-07-31 | 富士フイルム株式会社 | マイクロ流路デバイス |
| MY155579A (en) * | 2010-09-28 | 2015-11-03 | Mimos Berhad | Micromixing device for miniturization for use in microfluidic applications |
| USD650090S1 (en) * | 2011-01-18 | 2011-12-06 | Zach Odeh | Microfluidic device |
| CN102692515B (zh) * | 2011-03-23 | 2014-09-17 | 成功大学 | 血液凝固测试用的生医晶片与其制造方法及用途 |
| USD650091S1 (en) * | 2011-04-19 | 2011-12-06 | Zach Odeh | Microfluidic device |
| USD650911S1 (en) * | 2011-04-19 | 2011-12-20 | Zach Odeh | Microfluidic device |
| GB201109203D0 (en) * | 2011-06-01 | 2011-07-13 | Carclo Technical Plastics Ltd | Fluid flow control |
| CN104411406B (zh) * | 2012-03-16 | 2017-05-31 | 统计诊断与创新有限公司 | 具有集成传送模块的测试盒 |
| US9044729B2 (en) * | 2012-07-27 | 2015-06-02 | International Park Of Creativity | Methods and devices for electromagnetic amplification of nucleic acids |
| US10040018B2 (en) | 2013-01-09 | 2018-08-07 | Imagine Tf, Llc | Fluid filters and methods of use |
| US9506934B2 (en) * | 2013-04-29 | 2016-11-29 | Honeywell International Inc. | Polymer test cartridge mixer for cell lysis |
| TW201445135A (zh) * | 2013-05-23 | 2014-12-01 | Nat Applied Res Laboratories | 以複合電動力捕捉並分析生物微粒的方法與晶片 |
| US9861920B1 (en) | 2015-05-01 | 2018-01-09 | Imagine Tf, Llc | Three dimensional nanometer filters and methods of use |
| US10730047B2 (en) | 2014-06-24 | 2020-08-04 | Imagine Tf, Llc | Micro-channel fluid filters and methods of use |
| US10124275B2 (en) | 2014-09-05 | 2018-11-13 | Imagine Tf, Llc | Microstructure separation filters |
| WO2016133929A1 (en) | 2015-02-18 | 2016-08-25 | Imagine Tf, Llc | Three dimensional filter devices and apparatuses |
| CN104748656B (zh) * | 2015-03-20 | 2018-06-26 | 江苏大学 | 基于巨磁阻的微流控磁珠位置检测方法与装置 |
| US10118842B2 (en) | 2015-07-09 | 2018-11-06 | Imagine Tf, Llc | Deionizing fluid filter devices and methods of use |
| USD804682S1 (en) * | 2015-08-10 | 2017-12-05 | Opko Diagnostics, Llc | Multi-layered sample cassette |
| US10479046B2 (en) | 2015-08-19 | 2019-11-19 | Imagine Tf, Llc | Absorbent microstructure arrays and methods of use |
| CN108603827A (zh) * | 2015-09-11 | 2018-09-28 | 莱布尼茨光电技术研究所 | 用于个体化的患者血液分析的装置 |
| US10207266B2 (en) * | 2015-09-29 | 2019-02-19 | Foxconn Interconnect Technology Limited | Microfluidic device for detecting cells of blood |
| WO2017093780A1 (en) * | 2015-11-30 | 2017-06-08 | Rqmicro Ag | Microfluidic device, assemblies, and method for extracting particles from a sample |
| CN107344125A (zh) * | 2016-05-05 | 2017-11-14 | 李榕生 | 流体驱动方式特异的廉价的艾滋病诊断用微流控装置 |
| USD800336S1 (en) * | 2016-07-13 | 2017-10-17 | Precision Nanosystems Inc | Microfluidic cartridge |
| USD812242S1 (en) * | 2016-07-13 | 2018-03-06 | Precision Nanosystems Inc | Microfluidic cartridge |
| WO2018119401A2 (en) * | 2016-12-22 | 2018-06-28 | Daktari Diagnostics, Inc. | Devices and methods for determining one or more analytes in fluids |
| CN106655703B (zh) * | 2016-12-23 | 2019-04-16 | 上海大学 | 导电液体微量驱动装置及其应用 |
| CA3057501C (en) * | 2017-04-21 | 2021-10-26 | Abaxis, Inc. | Systems, devices and methods for microfluidic analysis |
| EP3697537A4 (en) | 2017-10-18 | 2021-10-20 | Group K Diagnostics, Inc. | SINGLE-LAYER MICROFLUIDIC DEVICE AND ITS MANUFACTURING AND USE METHODS |
| CN108536013B (zh) * | 2018-03-29 | 2021-02-26 | 宁波大学 | 终端封闭微通道中粒子移动耦合模型控制方法 |
| CN110433876B (zh) * | 2018-05-03 | 2022-05-17 | 香港科技大学 | 微流控装置及其制造方法、口罩和过滤悬浮颗粒的方法 |
| USD879999S1 (en) | 2018-11-02 | 2020-03-31 | Group K Diagnostics, Inc. | Microfluidic device |
| DE102019200109A1 (de) * | 2019-01-08 | 2020-07-09 | Robert Bosch Gmbh | Mikrofluidische Vorrichtung und Analysegerät für eine mikrofluidische Vorrichtung |
| KR102203994B1 (ko) * | 2019-01-25 | 2021-01-18 | 한국기술교육대학교 산학협력단 | 감염원에 대한 항생제 감수성 검사용 유체 칩 및 이의 제조방법 |
| USD951479S1 (en) * | 2019-06-24 | 2022-05-10 | Precision Nanosystems Inc. | Microfluidic cartridge |
| BR112022004179A2 (pt) * | 2019-09-10 | 2022-05-31 | Pioneer Hi Bred Int | Dispositivo e método para a análise genética de materiais de plantas em sítios de teste remotos |
| CN111190022A (zh) * | 2020-01-07 | 2020-05-22 | 中国科学院半导体研究所 | 基于谐振式传感器的生化检测系统及检测方法 |
| USD993443S1 (en) * | 2020-02-04 | 2023-07-25 | Ut-Battelle, Llc | Microfluidic glass chip interface bracket |
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| USD1016324S1 (en) | 2020-07-08 | 2024-02-27 | NanoCav, LLC | Biological cell processing chip |
| CN114100704B (zh) * | 2020-09-22 | 2022-12-06 | 中国科学院深圳先进技术研究院 | 一种磁分选微流控芯片及其制作方法 |
| USD983405S1 (en) * | 2021-04-15 | 2023-04-11 | Cytoaurora Biotechnologies, Inc. | Microfluidic chip |
| CN113522385B (zh) * | 2021-07-14 | 2022-07-22 | 中新国际联合研究院 | 一种磁性数字微流体的移动结构及其自动化设备 |
| CN113858540B (zh) * | 2021-10-08 | 2023-07-28 | 佛山华智新材料有限公司 | 微流控芯片及其制造方法 |
| US20250237669A1 (en) * | 2022-04-20 | 2025-07-24 | Hitachi High-Tech Corporation | Automatic analyzer |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020036141A1 (en) * | 2000-06-14 | 2002-03-28 | Gascoyne Peter R. C. | Method and apparatus for combined magnetophoretic and dielectrophoretic manipulation of analyte mixtures |
| WO2003057368A1 (en) * | 2002-01-14 | 2003-07-17 | Cambridge University Technical Services Ltd. | Microfluidic movement |
| EP1462174A1 (en) * | 2003-03-28 | 2004-09-29 | Interuniversitair Microelektronica Centrum Vzw | Method for the controlled transport of magnetic beads and device for executing said method |
| WO2006004558A1 (en) * | 2004-07-06 | 2006-01-12 | Agency For Science, Technology And Research | Biochip for sorting and lysing biological samples |
| EP1658890A2 (en) * | 2004-11-23 | 2006-05-24 | Samsung Electronics Co., Ltd. | Microfluidic device including microchannel on which plurality of electromagnets are disposed, and methods of mixing sample and lysing cells using the microfluidic device |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1462173A1 (en) * | 2003-03-28 | 2004-09-29 | Interuniversitair Micro-Elektronica Centrum (IMEC) | Method for the controlled transport of magnetic beads and devices for the method |
-
2007
- 2007-01-12 GB GB0700653A patent/GB2446204A/en not_active Withdrawn
-
2008
- 2008-01-11 CA CA002675079A patent/CA2675079A1/en not_active Abandoned
- 2008-01-11 EP EP08701775A patent/EP2117714A2/en not_active Withdrawn
- 2008-01-11 AU AU2008204364A patent/AU2008204364A1/en not_active Abandoned
- 2008-01-11 KR KR1020097016827A patent/KR20090104102A/ko not_active Withdrawn
- 2008-01-11 WO PCT/GB2008/000094 patent/WO2008084245A2/en not_active Ceased
- 2008-01-11 BR BRPI0806582-9A patent/BRPI0806582A2/pt not_active IP Right Cessation
- 2008-01-11 JP JP2009545234A patent/JP2010515913A/ja not_active Withdrawn
- 2008-01-11 MX MX2009007447A patent/MX2009007447A/es not_active Application Discontinuation
- 2008-01-11 CN CN200880007915A patent/CN101631616A/zh active Pending
- 2008-01-12 US US12/442,993 patent/US20100216126A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020036141A1 (en) * | 2000-06-14 | 2002-03-28 | Gascoyne Peter R. C. | Method and apparatus for combined magnetophoretic and dielectrophoretic manipulation of analyte mixtures |
| WO2003057368A1 (en) * | 2002-01-14 | 2003-07-17 | Cambridge University Technical Services Ltd. | Microfluidic movement |
| EP1462174A1 (en) * | 2003-03-28 | 2004-09-29 | Interuniversitair Microelektronica Centrum Vzw | Method for the controlled transport of magnetic beads and device for executing said method |
| WO2006004558A1 (en) * | 2004-07-06 | 2006-01-12 | Agency For Science, Technology And Research | Biochip for sorting and lysing biological samples |
| EP1658890A2 (en) * | 2004-11-23 | 2006-05-24 | Samsung Electronics Co., Ltd. | Microfluidic device including microchannel on which plurality of electromagnets are disposed, and methods of mixing sample and lysing cells using the microfluidic device |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9101933B2 (en) | 2008-10-10 | 2015-08-11 | University Of Hull | Microfluidic apparatus and method for DNA extraction, amplification and analysis |
| GB2483858A (en) * | 2010-09-21 | 2012-03-28 | Univ Hull | Amplifying nucleic acids using microfluidic device to perform PRC |
| CN107384776A (zh) * | 2017-08-04 | 2017-11-24 | 深圳市合川医疗科技有限公司 | 微流控芯片 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2675079A1 (en) | 2008-07-17 |
| MX2009007447A (es) | 2010-03-01 |
| US20100216126A1 (en) | 2010-08-26 |
| EP2117714A2 (en) | 2009-11-18 |
| BRPI0806582A2 (pt) | 2014-05-06 |
| WO2008084245A2 (en) | 2008-07-17 |
| KR20090104102A (ko) | 2009-10-05 |
| JP2010515913A (ja) | 2010-05-13 |
| CN101631616A (zh) | 2010-01-20 |
| GB0700653D0 (en) | 2007-02-21 |
| AU2008204364A1 (en) | 2008-07-17 |
| WO2008084245A3 (en) | 2009-03-19 |
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