CN101631616A - 微流体装置 - Google Patents

微流体装置 Download PDF

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Publication number
CN101631616A
CN101631616A CN200880007915A CN200880007915A CN101631616A CN 101631616 A CN101631616 A CN 101631616A CN 200880007915 A CN200880007915 A CN 200880007915A CN 200880007915 A CN200880007915 A CN 200880007915A CN 101631616 A CN101631616 A CN 101631616A
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carrying structure
microfluidic
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Inventor
瓦马德瓦·巴拉钱德兰
萨亚德·穆罕迈德·阿齐米
杰里米·阿埃伦
马苏德·佐尔加尔尼
穆罕迈德·礼萨·巴赫曼亚尔
普雷德拉格·斯利耶普切维奇
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Brunel University London
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Brunel University London
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Publication of CN101631616A publication Critical patent/CN101631616A/zh
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3032—Micromixers using magneto-hydrodynamic [MHD] phenomena to mix or move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/452—Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Fluid Mechanics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Electrochemistry (AREA)
  • Organic Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
CN200880007915A 2007-01-12 2008-01-11 微流体装置 Pending CN101631616A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0700653.9 2007-01-12
GB0700653A GB2446204A (en) 2007-01-12 2007-01-12 A Microfluidic device
PCT/GB2008/000094 WO2008084245A2 (en) 2007-01-12 2008-01-11 Microfluidic device

Publications (1)

Publication Number Publication Date
CN101631616A true CN101631616A (zh) 2010-01-20

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ID=37809900

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880007915A Pending CN101631616A (zh) 2007-01-12 2008-01-11 微流体装置

Country Status (11)

Country Link
US (1) US20100216126A1 (enExample)
EP (1) EP2117714A2 (enExample)
JP (1) JP2010515913A (enExample)
KR (1) KR20090104102A (enExample)
CN (1) CN101631616A (enExample)
AU (1) AU2008204364A1 (enExample)
BR (1) BRPI0806582A2 (enExample)
CA (1) CA2675079A1 (enExample)
GB (1) GB2446204A (enExample)
MX (1) MX2009007447A (enExample)
WO (1) WO2008084245A2 (enExample)

Cited By (14)

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CN102192977A (zh) * 2010-02-10 2011-09-21 富士胶片株式会社 微流体器件
CN102692515A (zh) * 2011-03-23 2012-09-26 成功大学 血液凝固测试用的生医晶片与其制造方法及用途
CN103842796A (zh) * 2011-06-01 2014-06-04 卡柯洛塑料技术有限公司 毛细管流体流动测量及用于其的毛细管流动设备
CN104122207A (zh) * 2013-04-29 2014-10-29 霍尼韦尔国际公司 用于细胞裂解的聚合物测试盒混合器
CN104748656A (zh) * 2015-03-20 2015-07-01 江苏大学 基于巨磁阻的微流控磁珠位置检测方法与装置
TWI494563B (enExample) * 2013-05-23 2015-08-01
CN105080626A (zh) * 2010-09-21 2015-11-25 赫尔大学 包括检测仪器和微流体装置的系统
CN106655703A (zh) * 2016-12-23 2017-05-10 上海大学 导电液体微量驱动装置及其应用
CN107344125A (zh) * 2016-05-05 2017-11-14 李榕生 流体驱动方式特异的廉价的艾滋病诊断用微流控装置
CN108430634A (zh) * 2015-11-30 2018-08-21 快速定量微生物学股份有限公司 微流体装置、组件和从样品提取颗粒的方法
CN108536013A (zh) * 2018-03-29 2018-09-14 宁波大学 终端封闭微通道中粒子移动耦合模型控制方法
CN108603827A (zh) * 2015-09-11 2018-09-28 莱布尼茨光电技术研究所 用于个体化的患者血液分析的装置
CN110730690A (zh) * 2017-04-21 2020-01-24 爱贝斯股份有限公司 用于微流体分析的系统、装置和方法
CN111190022A (zh) * 2020-01-07 2020-05-22 中国科学院半导体研究所 基于谐振式传感器的生化检测系统及检测方法

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CN107384776A (zh) * 2017-08-04 2017-11-24 深圳市合川医疗科技有限公司 微流控芯片
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CN110433876B (zh) * 2018-05-03 2022-05-17 香港科技大学 微流控装置及其制造方法、口罩和过滤悬浮颗粒的方法
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DE102019200109A1 (de) * 2019-01-08 2020-07-09 Robert Bosch Gmbh Mikrofluidische Vorrichtung und Analysegerät für eine mikrofluidische Vorrichtung
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CN113522385B (zh) * 2021-07-14 2022-07-22 中新国际联合研究院 一种磁性数字微流体的移动结构及其自动化设备
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Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102192977B (zh) * 2010-02-10 2014-10-29 富士胶片株式会社 微流体器件
CN102192977A (zh) * 2010-02-10 2011-09-21 富士胶片株式会社 微流体器件
CN105080626A (zh) * 2010-09-21 2015-11-25 赫尔大学 包括检测仪器和微流体装置的系统
CN102692515B (zh) * 2011-03-23 2014-09-17 成功大学 血液凝固测试用的生医晶片与其制造方法及用途
CN102692515A (zh) * 2011-03-23 2012-09-26 成功大学 血液凝固测试用的生医晶片与其制造方法及用途
CN103842796A (zh) * 2011-06-01 2014-06-04 卡柯洛塑料技术有限公司 毛细管流体流动测量及用于其的毛细管流动设备
CN104122207A (zh) * 2013-04-29 2014-10-29 霍尼韦尔国际公司 用于细胞裂解的聚合物测试盒混合器
CN104122207B (zh) * 2013-04-29 2019-02-05 霍尼韦尔国际公司 用于细胞裂解的聚合物测试盒混合器
TWI494563B (enExample) * 2013-05-23 2015-08-01
CN104748656A (zh) * 2015-03-20 2015-07-01 江苏大学 基于巨磁阻的微流控磁珠位置检测方法与装置
CN108603827A (zh) * 2015-09-11 2018-09-28 莱布尼茨光电技术研究所 用于个体化的患者血液分析的装置
CN108430634A (zh) * 2015-11-30 2018-08-21 快速定量微生物学股份有限公司 微流体装置、组件和从样品提取颗粒的方法
CN107344125A (zh) * 2016-05-05 2017-11-14 李榕生 流体驱动方式特异的廉价的艾滋病诊断用微流控装置
CN106655703A (zh) * 2016-12-23 2017-05-10 上海大学 导电液体微量驱动装置及其应用
CN106655703B (zh) * 2016-12-23 2019-04-16 上海大学 导电液体微量驱动装置及其应用
CN110730690A (zh) * 2017-04-21 2020-01-24 爱贝斯股份有限公司 用于微流体分析的系统、装置和方法
CN108536013A (zh) * 2018-03-29 2018-09-14 宁波大学 终端封闭微通道中粒子移动耦合模型控制方法
CN108536013B (zh) * 2018-03-29 2021-02-26 宁波大学 终端封闭微通道中粒子移动耦合模型控制方法
CN111190022A (zh) * 2020-01-07 2020-05-22 中国科学院半导体研究所 基于谐振式传感器的生化检测系统及检测方法

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