GB2296495B - Anthracycline derivatives - Google Patents

Anthracycline derivatives

Info

Publication number
GB2296495B
GB2296495B GB9426075A GB9426075A GB2296495B GB 2296495 B GB2296495 B GB 2296495B GB 9426075 A GB9426075 A GB 9426075A GB 9426075 A GB9426075 A GB 9426075A GB 2296495 B GB2296495 B GB 2296495B
Authority
GB
United Kingdom
Prior art keywords
anthracycline derivatives
anthracycline
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB9426075A
Other languages
English (en)
Other versions
GB2296495A (en
GB9426075D0 (en
Inventor
Michele Caruso
Alberto Bargiotti
Cristina Geroni
Antonino Suarato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Pharmacia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA, Pharmacia SpA filed Critical Farmitalia Carlo Erba SRL
Priority to GB9426075A priority Critical patent/GB2296495B/en
Publication of GB9426075D0 publication Critical patent/GB9426075D0/en
Priority to IT95MI002614A priority patent/IT1277073B1/it
Priority to DE19547958.0A priority patent/DE19547958B4/de
Priority to JP33521695A priority patent/JP4081148B2/ja
Publication of GB2296495A publication Critical patent/GB2296495A/en
Application granted granted Critical
Publication of GB2296495B publication Critical patent/GB2296495B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB9426075A 1994-12-23 1994-12-23 Anthracycline derivatives Expired - Lifetime GB2296495B (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB9426075A GB2296495B (en) 1994-12-23 1994-12-23 Anthracycline derivatives
IT95MI002614A IT1277073B1 (it) 1994-12-23 1995-12-13 Derivati antraciclinici
DE19547958.0A DE19547958B4 (de) 1994-12-23 1995-12-21 Anthracyclin-Derivate
JP33521695A JP4081148B2 (ja) 1994-12-23 1995-12-22 アントラサイクリン誘導体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9426075A GB2296495B (en) 1994-12-23 1994-12-23 Anthracycline derivatives

Publications (3)

Publication Number Publication Date
GB9426075D0 GB9426075D0 (en) 1995-02-22
GB2296495A GB2296495A (en) 1996-07-03
GB2296495B true GB2296495B (en) 1998-04-15

Family

ID=10766488

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9426075A Expired - Lifetime GB2296495B (en) 1994-12-23 1994-12-23 Anthracycline derivatives

Country Status (4)

Country Link
JP (1) JP4081148B2 (enrdf_load_stackoverflow)
DE (1) DE19547958B4 (enrdf_load_stackoverflow)
GB (1) GB2296495B (enrdf_load_stackoverflow)
IT (1) IT1277073B1 (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021031599A1 (zh) * 2019-08-22 2021-02-25 联宁（苏州）生物制药有限公司 一种用于抗体药物偶联物的药物毒素pnu-159682的制备方法及其中间体

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2315067B (en) * 1996-07-11 2000-02-16 Pharmacia Spa Morpholinyl anthracycline derivatives
EP1242438B1 (en) * 1999-12-29 2006-11-08 Immunogen, Inc. Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
AU2004222527A1 (en) * 2003-03-18 2004-09-30 Pharmacia Italia Spa Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor
RU2005132175A (ru) * 2003-03-18 2006-01-27 Фармация Италия С.П.А. (It) Комбинированное лечение опухолей, включающее неморубицин и лучевую терапию
WO2009099741A1 (en) 2008-02-01 2009-08-13 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
EP2277884B1 (en) * 2008-04-11 2017-08-23 Tianjin Hemay Oncology Pharmaceutical Co., Ltd Anthracycline antibiotic derivatives with high activity, preparation methods and uses thereof
KR101328315B1 (ko) * 2008-04-11 2013-11-11 티안진 헤메이 바이오-텍 컴퍼니 리미티드 고활성의 안트라사이클린 항생물질 유도체, 이의 제조방법 및 사용
AR072804A1 (es) 2008-07-15 2010-09-22 Genentech Inc Conjugados derivados de antraciclina,proceso para su preparacion,composiciones farmaceuticas que los contienen y su uso como agentes antitumorales.
CA2818713C (en) 2010-12-02 2019-03-26 Nerviano Medical Sciences S.R.L. Process for the preparation of morpholinyl anthracycline derivatives
ES2633359T3 (es) * 2012-03-06 2017-09-20 Tianjin Hemay Oncology Pharmaceutical Co., Ltd. Derivados de antraquinona tetracíclica
DK2991993T3 (en) * 2013-04-29 2018-07-30 Nerviano Medical Sciences Srl NEW MORPHOLINYLANTHRACYCLINE DERIVATIVES
WO2016071418A1 (en) 2014-11-05 2016-05-12 Nerviano Medical Sciences S.R.L. Functionalized morpholinyl anthracycline derivatives
WO2025092728A1 (zh) * 2023-10-30 2025-05-08 上海皓元生物医药科技有限公司 一种pnu-159682的中间体及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301277A (en) * 1980-10-20 1981-11-17 Sri International 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
JPS57163393A (en) * 1981-03-27 1982-10-07 Microbial Chem Res Found Novel anthracyclin derivative and its preparation
JPS59212499A (ja) * 1983-05-13 1984-12-01 アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド 抗腫瘍性抗生物質アントラサイクリンの４−デメトキシ−３′−デアミノ−３′（４−モリホリニル）誘導体
US4585859A (en) * 1983-05-24 1986-04-29 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021031599A1 (zh) * 2019-08-22 2021-02-25 联宁（苏州）生物制药有限公司 一种用于抗体药物偶联物的药物毒素pnu-159682的制备方法及其中间体
AU2020333565B2 (en) * 2019-08-22 2022-07-21 Levena Biopharma Co., Ltd. Method for preparing drug toxin PNU-159682 of antibody drug conjugate, and intermediate therein

Also Published As

Publication number Publication date
GB2296495A (en) 1996-07-03
DE19547958B4 (de) 2015-01-22
JP4081148B2 (ja) 2008-04-23
IT1277073B1 (it) 1997-11-04
JPH08231581A (ja) 1996-09-10
GB9426075D0 (en) 1995-02-22
ITMI952614A0 (enrdf_load_stackoverflow) 1995-12-13
DE19547958A1 (de) 1996-06-27
ITMI952614A1 (it) 1997-06-13

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Legal Events

Date Code Title Description
730A Proceeding under section 30 patents act 1977
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
PE20 Patent expired after termination of 20 years

Expiry date: 20141222