ITMI952614A0 - - Google Patents

Info

Publication number
ITMI952614A0
ITMI952614A0 ITMI952614A ITMI952614A ITMI952614A0 IT MI952614 A0 ITMI952614 A0 IT MI952614A0 IT MI952614 A ITMI952614 A IT MI952614A IT MI952614 A ITMI952614 A IT MI952614A IT MI952614 A0 ITMI952614 A0 IT MI952614A0
Authority
IT
Italy
Application number
ITMI952614A
Other languages
Italian (it)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ITMI952614A0 publication Critical patent/ITMI952614A0/it
Publication of ITMI952614A1 publication Critical patent/ITMI952614A1/it
Application granted granted Critical
Publication of IT1277073B1 publication Critical patent/IT1277073B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT95MI002614A 1994-12-23 1995-12-13 Derivati antraciclinici IT1277073B1 (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9426075A GB2296495B (en) 1994-12-23 1994-12-23 Anthracycline derivatives

Publications (3)

Publication Number Publication Date
ITMI952614A0 true ITMI952614A0 (enrdf_load_stackoverflow) 1995-12-13
ITMI952614A1 ITMI952614A1 (it) 1997-06-13
IT1277073B1 IT1277073B1 (it) 1997-11-04

Family

ID=10766488

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95MI002614A IT1277073B1 (it) 1994-12-23 1995-12-13 Derivati antraciclinici

Country Status (4)

Country Link
JP (1) JP4081148B2 (enrdf_load_stackoverflow)
DE (1) DE19547958B4 (enrdf_load_stackoverflow)
GB (1) GB2296495B (enrdf_load_stackoverflow)
IT (1) IT1277073B1 (enrdf_load_stackoverflow)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2315067B (en) * 1996-07-11 2000-02-16 Pharmacia Spa Morpholinyl anthracycline derivatives
ES2274823T3 (es) * 1999-12-29 2007-06-01 Immunogen, Inc. Agentes cototoxicos que comprenden doxorrubicinas y daunorrubicinas y su utilizacion terapeutica.
AU2004222527A1 (en) * 2003-03-18 2004-09-30 Pharmacia Italia Spa Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor
CA2519289A1 (en) * 2003-03-18 2004-09-30 Antonino Suarato Nemorubicin as radiosensitizer in combination with radiation therapy against tumors
US8742076B2 (en) 2008-02-01 2014-06-03 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
AU2009235897B2 (en) * 2008-04-11 2012-04-12 Tianjin Hemay Oncology Pharmaceutical Co., Ltd Anthracycline antibiotic derivatives with high activity, preparation methods and uses thereof
BRPI0911647A2 (pt) * 2008-04-11 2015-10-13 Tianjin Hemay Bio Tech Co Ltd compostos derivados de antibióticos de antraciclina com alta atividade, métodos de preeparação e uso dos mesmos.
JP6067222B2 (ja) 2008-07-15 2017-01-25 ジェネンテック， インコーポレイテッド アントラサイクリン誘導体コンジュゲート、その調製方法及び抗腫瘍化合物としてのその用途
US8470984B2 (en) 2010-12-02 2013-06-25 Nerviano Medical Sciences S.R.L. Process for the preparation of morpholinyl anthracycline derivatives
JP6104287B2 (ja) * 2012-03-06 2017-03-29 天津和美生物技術有限公司 四環系アントラキノン誘導体
DK2991993T3 (en) * 2013-04-29 2018-07-30 Nerviano Medical Sciences Srl NEW MORPHOLINYLANTHRACYCLINE DERIVATIVES
WO2016071418A1 (en) 2014-11-05 2016-05-12 Nerviano Medical Sciences S.R.L. Functionalized morpholinyl anthracycline derivatives
CN110776501B (zh) * 2019-08-22 2021-04-02 联宁（苏州）生物制药有限公司 一种用于抗体药物偶联物的药物毒素pnu-159682的制备方法及其中间体
WO2025092728A1 (zh) * 2023-10-30 2025-05-08 上海皓元生物医药科技有限公司 一种pnu-159682的中间体及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301277A (en) * 1980-10-20 1981-11-17 Sri International 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
JPS57163393A (en) * 1981-03-27 1982-10-07 Microbial Chem Res Found Novel anthracyclin derivative and its preparation
JPS59212499A (ja) * 1983-05-13 1984-12-01 アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド 抗腫瘍性抗生物質アントラサイクリンの４−デメトキシ−３′−デアミノ−３′（４−モリホリニル）誘導体
US4585859A (en) * 1983-05-24 1986-04-29 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin

Also Published As

Publication number Publication date
GB9426075D0 (en) 1995-02-22
DE19547958A1 (de) 1996-06-27
JPH08231581A (ja) 1996-09-10
JP4081148B2 (ja) 2008-04-23
DE19547958B4 (de) 2015-01-22
GB2296495A (en) 1996-07-03
GB2296495B (en) 1998-04-15
ITMI952614A1 (it) 1997-06-13
IT1277073B1 (it) 1997-11-04

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Legal Events

Date Code Title Description
0001 Granted