GB2285805A - Esters - Google Patents

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Info

Publication number
GB2285805A
GB2285805A GB9400882A GB9400882A GB2285805A GB 2285805 A GB2285805 A GB 2285805A GB 9400882 A GB9400882 A GB 9400882A GB 9400882 A GB9400882 A GB 9400882A GB 2285805 A GB2285805 A GB 2285805A
Authority
GB
United Kingdom
Prior art keywords
acid
formulae
acid bis
bis
stigmasteryiester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB9400882A
Other languages
English (en)
Other versions
GB9400882D0 (en
Inventor
Carl Eugster
Conrad Hans Eugster
Walter Haldemann
Giorgio Rivara
Giuseppe Zina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Marigen SA
Original Assignee
Marigen SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CH3159/91A priority Critical patent/CH681891A5/de
Priority to DE4319492A priority patent/DE4319492A1/de
Application filed by Marigen SA filed Critical Marigen SA
Priority to GB9400882A priority patent/GB2285805A/en
Publication of GB9400882D0 publication Critical patent/GB9400882D0/en
Publication of GB2285805A publication Critical patent/GB2285805A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
GB9400882A 1992-10-09 1994-01-18 Esters Withdrawn GB2285805A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CH3159/91A CH681891A5 (xx) 1992-10-09 1992-10-09
DE4319492A DE4319492A1 (de) 1992-10-09 1993-06-11 Dicarbonsäureester
GB9400882A GB2285805A (en) 1992-10-09 1994-01-18 Esters

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH3159/91A CH681891A5 (xx) 1992-10-09 1992-10-09
GB9400882A GB2285805A (en) 1992-10-09 1994-01-18 Esters

Publications (2)

Publication Number Publication Date
GB9400882D0 GB9400882D0 (en) 1994-03-16
GB2285805A true GB2285805A (en) 1995-07-26

Family

ID=25692340

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9400882A Withdrawn GB2285805A (en) 1992-10-09 1994-01-18 Esters

Country Status (3)

Country Link
CH (1) CH681891A5 (xx)
DE (1) DE4319492A1 (xx)
GB (1) GB2285805A (xx)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5892068A (en) * 1998-08-25 1999-04-06 Mcneil-Ppc, Inc. Preparation of sterol and stanol-esters
EP0946485A2 (en) * 1996-11-12 1999-10-06 Tamarkin Pharmaceutical Innovation Ltd. Method for treatment of dermatological disorders
EP1045641A1 (en) * 1997-12-16 2000-10-25 Cognis Corporation Sterol esters as food additives
US7084172B2 (en) * 2001-09-17 2006-08-01 Pierre Fabre Dermo-Cosmetique Bioprecursors for percutaneous application
US8148414B2 (en) 2008-08-19 2012-04-03 Xenoport, Inc. Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US9302977B2 (en) 2013-06-07 2016-04-05 Xenoport, Inc. Method of making monomethyl fumarate
US9416096B2 (en) 2013-09-06 2016-08-16 Xenoport, Inc. Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use
US9421182B2 (en) 2013-06-21 2016-08-23 Xenoport, Inc. Cocrystals of dimethyl fumarate
US9505776B2 (en) 2013-03-14 2016-11-29 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US9597292B2 (en) 2012-08-22 2017-03-21 Xenoport, Inc. Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof
US9604922B2 (en) 2014-02-24 2017-03-28 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters
US10179118B2 (en) 2013-03-24 2019-01-15 Arbor Pharmaceuticals, Llc Pharmaceutical compositions of dimethyl fumarate
US10222388B2 (en) 2013-08-07 2019-03-05 Orgentec Diagnostika Gmbh 25-OH vitamin D derivatives for determining vitamin D metabolites
US10945984B2 (en) 2012-08-22 2021-03-16 Arbor Pharmaceuticals, Llc Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH681891A5 (xx) * 1992-10-09 1993-06-15 Marigen Sa
US5593691A (en) * 1993-06-03 1997-01-14 Marigen S.A. Biotenside solvents for pharmaceuticals and cosmetics
FI974648A (fi) * 1997-09-09 1999-05-06 Raisio Benecol Oy Hydroksihappo-, maitohappo- ja hydroksialkanoaattiesterit ja niiden käyttö
CN104434927A (zh) * 2014-12-16 2015-03-25 吉林农业大学 丙二酸双环戊烷并多氢菲酯b在制备降血压药物中的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB760346A (en) * 1952-12-18 1956-10-31 Roche Products Ltd Novel esters of bixins and norbixins and process for the manufacture thereof
EP0195311A2 (en) * 1985-03-06 1986-09-24 Nippon Fine Chemical Co., Ltd. Process for preparing fatty acid esters
US5198432A (en) * 1988-01-29 1993-03-30 Center For Innovative Technology Method of preventing chlorohydrocarbon toxicity using sterol derivatives
CH681891A5 (xx) * 1992-10-09 1993-06-15 Marigen Sa

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB760346A (en) * 1952-12-18 1956-10-31 Roche Products Ltd Novel esters of bixins and norbixins and process for the manufacture thereof
EP0195311A2 (en) * 1985-03-06 1986-09-24 Nippon Fine Chemical Co., Ltd. Process for preparing fatty acid esters
US5198432A (en) * 1988-01-29 1993-03-30 Center For Innovative Technology Method of preventing chlorohydrocarbon toxicity using sterol derivatives
CH681891A5 (xx) * 1992-10-09 1993-06-15 Marigen Sa

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CA 108(22):194660g *
CA 97(14):117240x *

Cited By (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180669B1 (en) 1996-11-12 2001-01-30 Tamarkin Pharmaceutical Innovation Ltd. Method for treatment of dermatological disorders
EP0946485A2 (en) * 1996-11-12 1999-10-06 Tamarkin Pharmaceutical Innovation Ltd. Method for treatment of dermatological disorders
EP0946485A4 (en) * 1996-11-12 2000-01-19 Tamarkin Pharmaceutical Innova METHOD FOR TREATING DERMATOLOGICAL DISEASES
EP1045641A4 (en) * 1997-12-16 2003-03-19 Cognis Corp STEROLESTER AS A FOOD ADDITIVE
EP1045641A1 (en) * 1997-12-16 2000-10-25 Cognis Corporation Sterol esters as food additives
US6713466B2 (en) 1997-12-16 2004-03-30 Cognis Corporation Processes for preparing sterol esters
US6147236A (en) * 1998-08-25 2000-11-14 Mcneil-Ppc, Inc. Preparation of sterol and stanol-esters
US5892068A (en) * 1998-08-25 1999-04-06 Mcneil-Ppc, Inc. Preparation of sterol and stanol-esters
US7084172B2 (en) * 2001-09-17 2006-08-01 Pierre Fabre Dermo-Cosmetique Bioprecursors for percutaneous application
US9452972B2 (en) 2008-08-19 2016-09-27 Xenoport, Inc. Methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof
US8148414B2 (en) 2008-08-19 2012-04-03 Xenoport, Inc. Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use
US8778991B2 (en) 2008-08-19 2014-07-15 Xenoport, Inc. Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use
US8785443B2 (en) 2008-08-19 2014-07-22 Xenoport, Inc. Methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof
US10716760B2 (en) 2012-08-22 2020-07-21 Arbor Pharmaceuticals, Llc Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof
US9597292B2 (en) 2012-08-22 2017-03-21 Xenoport, Inc. Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof
US10945984B2 (en) 2012-08-22 2021-03-16 Arbor Pharmaceuticals, Llc Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects
US10940117B2 (en) 2012-08-22 2021-03-09 Arbor Pharmaceuticals, Llc Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof
US11679092B2 (en) 2013-03-14 2023-06-20 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US11230548B2 (en) 2013-03-14 2022-01-25 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US9090558B2 (en) 2013-03-14 2015-07-28 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US11083703B2 (en) 2013-03-14 2021-08-10 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US11905298B2 (en) 2013-03-14 2024-02-20 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US12076306B2 (en) 2013-03-14 2024-09-03 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US9505776B2 (en) 2013-03-14 2016-11-29 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US10406133B2 (en) 2013-03-14 2019-09-10 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US10596140B2 (en) 2013-03-14 2020-03-24 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US10179118B2 (en) 2013-03-24 2019-01-15 Arbor Pharmaceuticals, Llc Pharmaceutical compositions of dimethyl fumarate
US11938111B2 (en) 2013-03-24 2024-03-26 Arbor Pharmaceuticals, Llc Pharmaceutical compositions of dimethyl fumarate
US9302977B2 (en) 2013-06-07 2016-04-05 Xenoport, Inc. Method of making monomethyl fumarate
US9421182B2 (en) 2013-06-21 2016-08-23 Xenoport, Inc. Cocrystals of dimethyl fumarate
US11199553B2 (en) 2013-08-07 2021-12-14 Orgentec Diagnostika Gmbh 25-OH vitamin D derivatives for determining vitamin D metabolites
US10222388B2 (en) 2013-08-07 2019-03-05 Orgentec Diagnostika Gmbh 25-OH vitamin D derivatives for determining vitamin D metabolites
US9682057B2 (en) 2013-09-06 2017-06-20 Xenoport, Inc. Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use
US9416096B2 (en) 2013-09-06 2016-08-16 Xenoport, Inc. Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use
US9604922B2 (en) 2014-02-24 2017-03-28 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
US11135296B2 (en) 2014-03-24 2021-10-05 Arbor Pharmaceuticals, Llc Pharmaceutical compositions of fumaric acid esters
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters

Also Published As

Publication number Publication date
DE4319492A1 (de) 1994-04-14
GB9400882D0 (en) 1994-03-16
CH681891A5 (xx) 1993-06-15

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)