GB2133401B - Benzoazacycloalkyl-spiro-imidazolidines - Google Patents

Benzoazacycloalkyl-spiro-imidazolidines

Info

Publication number
GB2133401B
GB2133401B GB08311508A GB8311508A GB2133401B GB 2133401 B GB2133401 B GB 2133401B GB 08311508 A GB08311508 A GB 08311508A GB 8311508 A GB8311508 A GB 8311508A GB 2133401 B GB2133401 B GB 2133401B
Authority
GB
United Kingdom
Prior art keywords
benzoazacycloalkyl
imidazolidines
spiro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08311508A
Other languages
English (en)
Other versions
GB8311508D0 (en
GB2133401A (en
Inventor
Charles Malen
Jean-Louis Peglion
Jacques Duhault
Michelle Boulanger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of GB8311508D0 publication Critical patent/GB8311508D0/en
Publication of GB2133401A publication Critical patent/GB2133401A/en
Application granted granted Critical
Publication of GB2133401B publication Critical patent/GB2133401B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
GB08311508A 1982-04-27 1983-04-27 Benzoazacycloalkyl-spiro-imidazolidines Expired GB2133401B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8207203A FR2525603A1 (fr) 1982-04-27 1982-04-27 Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique

Publications (3)

Publication Number Publication Date
GB8311508D0 GB8311508D0 (en) 1983-06-02
GB2133401A GB2133401A (en) 1984-07-25
GB2133401B true GB2133401B (en) 1985-10-23

Family

ID=9273425

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08311508A Expired GB2133401B (en) 1982-04-27 1983-04-27 Benzoazacycloalkyl-spiro-imidazolidines

Country Status (22)

Country Link
JP (1) JPS5910584A (no)
KR (1) KR840004428A (no)
AT (1) ATA125383A (no)
AU (1) AU1395383A (no)
BE (1) BE896572A (no)
DD (1) DD209833A5 (no)
DE (1) DE3315106A1 (no)
DK (1) DK183583A (no)
ES (1) ES521895A0 (no)
FR (1) FR2525603A1 (no)
GB (1) GB2133401B (no)
GR (1) GR78481B (no)
IL (1) IL68497A0 (no)
IT (1) IT1167123B (no)
LU (1) LU84770A1 (no)
MA (1) MA19783A1 (no)
NL (1) NL8301476A (no)
NO (1) NO831473L (no)
OA (1) OA07412A (no)
PT (1) PT76595B (no)
SE (1) SE8302347L (no)
ZA (1) ZA832927B (no)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8822727B2 (en) 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
US8999970B2 (en) 2010-09-01 2015-04-07 Arena Pharmaceuticals, Inc. Administration of an anti-obesity compound to individuals with renal impairment
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
US9169213B2 (en) 2012-10-09 2015-10-27 Arena Pharmaceuticals, Inc. Method of weight management
US9248133B2 (en) 2010-09-01 2016-02-02 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
US9365521B2 (en) 2010-09-01 2016-06-14 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-HT2C agonists

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4927831A (en) * 1988-10-20 1990-05-22 American Home Products Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
EP2332920A3 (en) 2003-06-17 2011-12-21 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
PL2332921T3 (pl) 2003-06-17 2016-08-31 Arena Pharm Inc Chlorowodorek 8-chloro-1-metylo-2,3,4,5-tetrahydro-1H-3-benzazepiny
CN101084193B (zh) 2004-12-21 2011-12-07 艾尼纳制药公司 (r)-8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓盐酸盐的晶型
SG158168A1 (en) 2004-12-23 2010-01-29 Arena Pharm Inc 5ht2c receptor modulator compositions and methods of use
JP5199997B2 (ja) 2006-04-03 2013-05-15 アリーナ ファーマシューティカルズ， インコーポレイテッド ８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンズアゼピンおよびこれに関連する中間体を調製するためのプロセス
ES2522587T3 (es) 2006-12-05 2014-11-17 Arena Pharmaceuticals, Inc. Procesos para preparar (R)-8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzacepina e intermedios de la misma
WO2010148207A2 (en) 2009-06-18 2010-12-23 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
JP6272695B2 (ja) 2010-09-01 2018-01-31 エーザイ・アール・アンド・ディー・マネジメント株式会社 体重管理のために有用な５−ｈｔ２ｃアゴニストの改変放出剤形

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4209630A (en) * 1976-10-18 1980-06-24 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4235911A (en) * 1979-06-13 1980-11-25 Pfizer Inc. Hydantoin derivatives

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8822727B2 (en) 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
US8999970B2 (en) 2010-09-01 2015-04-07 Arena Pharmaceuticals, Inc. Administration of an anti-obesity compound to individuals with renal impairment
US9248133B2 (en) 2010-09-01 2016-02-02 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
US9365521B2 (en) 2010-09-01 2016-06-14 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-HT2C agonists
US9169213B2 (en) 2012-10-09 2015-10-27 Arena Pharmaceuticals, Inc. Method of weight management

Also Published As

Publication number Publication date
PT76595A (fr) 1983-05-01
SE8302347D0 (sv) 1983-04-26
OA07412A (fr) 1984-11-30
MA19783A1 (fr) 1983-12-31
PT76595B (fr) 1986-01-21
DK183583A (da) 1983-10-28
LU84770A1 (fr) 1984-11-28
DE3315106A1 (de) 1983-11-03
NO831473L (no) 1983-10-28
GB8311508D0 (en) 1983-06-02
BE896572A (fr) 1983-10-26
DK183583D0 (da) 1983-04-26
FR2525603B1 (no) 1984-09-14
SE8302347L (sv) 1983-10-28
ES8405796A1 (es) 1984-06-16
GB2133401A (en) 1984-07-25
DD209833A5 (de) 1984-05-23
GR78481B (no) 1984-09-27
IT8348155A0 (it) 1983-04-26
IT1167123B (it) 1987-05-13
NL8301476A (nl) 1983-11-16
ATA125383A (de) 1986-05-15
JPS5910584A (ja) 1984-01-20
AU1395383A (en) 1983-11-03
ZA832927B (en) 1984-06-27
FR2525603A1 (fr) 1983-10-28
KR840004428A (ko) 1984-10-15
IL68497A0 (en) 1983-07-31
ES521895A0 (es) 1984-06-16

Similar Documents

Publication Publication Date Title
CS203883A2 (en) Zpusob pripravy perletove lesklych pigmentu
CS124683A2 (en) Zpusob zapouzdreni ucinne latky chemickeho prostredku
GB2133401B (en) Benzoazacycloalkyl-spiro-imidazolidines
AR242637A1 (es) Zurradera (maquina de zurrar) para el procesamiento de cueros y pieles.
CS130683A1 (en) Mezihridelove radialne celni kontaktni tesneni
CS102482A1 (en) Stabilizacni zarizeni plasmoveho generatoru
CS1010682A1 (en) Samosvorny hydraulicky obvod
CA50080S (en) Bruach
CA50163S (en) Skillet-oven
CS1002282A1 (en) Zpusob vyroby nagneticky mekkych ocelovych plechu nebo pasu
AU87474S (en) Drain-outlet closure-plug
AU89092S (en) Aquabike
AU88266S (en) Boardgame
CS211582A1 (en) Davkovac tekutin
CS208482A1 (en) Uzavrene samostredici upinadlo
CS1000682A1 (en) Zpusob likvidace porubu pomoci sekci posuvne vyztuze
BG34948A1 (en) Box- pallet
BG35995A1 (en) Hydrotransmission
BG37338A1 (en) Hydrovibrator
BG45685A1 (en) Rc- generator
AU87492S (en) Rangehood
CS1001482A1 (en) Vpichovana netkana textilie
CS1002182A1 (en) Zpusob vyroby magneticky mekkych ocelovych plechu nebo pasu
AU87491S (en) Rangehood
CS1002882A1 (en) Ochrana vysokofrekvencnich rozvodu

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee