GB2132616B - Improvements in or relating to novel cephalosporin intermediates - Google Patents

Improvements in or relating to novel cephalosporin intermediates

Info

Publication number
GB2132616B
GB2132616B GB8333667A GB8333667A GB2132616B GB 2132616 B GB2132616 B GB 2132616B GB 8333667 A GB8333667 A GB 8333667A GB 8333667 A GB8333667 A GB 8333667A GB 2132616 B GB2132616 B GB 2132616B
Authority
GB
United Kingdom
Prior art keywords
relating
novel cephalosporin
cephalosporin intermediates
intermediates
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8333667A
Other languages
English (en)
Other versions
GB8333667D0 (en
GB2132616A (en
Inventor
Ta-Sen Chou
Perry Clark Heath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of GB8333667D0 publication Critical patent/GB8333667D0/en
Publication of GB2132616A publication Critical patent/GB2132616A/en
Application granted granted Critical
Publication of GB2132616B publication Critical patent/GB2132616B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
GB8333667A 1982-12-27 1983-12-16 Improvements in or relating to novel cephalosporin intermediates Expired GB2132616B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45344582A 1982-12-27 1982-12-27

Publications (3)

Publication Number Publication Date
GB8333667D0 GB8333667D0 (en) 1984-01-25
GB2132616A GB2132616A (en) 1984-07-11
GB2132616B true GB2132616B (en) 1986-08-06

Family

ID=23800618

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8333667A Expired GB2132616B (en) 1982-12-27 1983-12-16 Improvements in or relating to novel cephalosporin intermediates

Country Status (13)

Country Link
US (1) US4525587A (enExample)
EP (1) EP0113568B1 (enExample)
JP (2) JPH0834744B2 (enExample)
KR (1) KR870000612B1 (enExample)
CA (1) CA1245629A (enExample)
DE (1) DE3381408D1 (enExample)
DK (1) DK164061C (enExample)
GB (1) GB2132616B (enExample)
GR (1) GR79485B (enExample)
HK (1) HK17089A (enExample)
HU (1) HU191911B (enExample)
IE (1) IE56485B1 (enExample)
IL (1) IL70470A (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4694079A (en) * 1985-07-29 1987-09-15 Bristol-Myers Company 3-propenyl cephalosporin solvates
AT387022B (de) * 1986-06-04 1988-11-25 Biochemie Gmbh Verfahren zur herstellung einer neuen kristallinen form eines cefalosporinderivats
US4734408A (en) * 1986-12-17 1988-03-29 Eli Lilly And Company Crystalline cephalosporin antibiotic salts and solvates
AT388736B (de) * 1987-10-08 1989-08-25 Biochemie Gmbh Neue stabile, kristalline formen des ceftazidime-t-butylesters und verfahren zu ihrer herstellung
GB8802622D0 (en) * 1988-02-05 1988-03-02 Glaxo Group Ltd Chemical compound
US5831085A (en) * 1997-01-16 1998-11-03 Lupin Laboratories Limited Process for manufacture of cephalosporin such as ceftazidime and intermediate thereof
CN106317081B (zh) * 2016-08-22 2018-08-31 山东罗欣药业集团恒欣药业有限公司 一种抗感染药物头孢他啶晶体化合物及其药物组合物
CN106397458A (zh) * 2016-09-23 2017-02-15 临沂草之美医药科技有限公司 一种治疗外科手术感染的药物头孢他啶晶体化合物
CN106432280A (zh) * 2016-09-23 2017-02-22 临沂草之美医药科技有限公司 一种治疗外科手术感染的药物头孢他啶晶体化合物
CN107722040A (zh) * 2017-10-10 2018-02-23 南京志坤环保科技有限公司 一种回收利用头孢他啶母液的膜分离方法及装置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6056717B2 (ja) * 1977-09-27 1985-12-11 富山化学工業株式会社 セフアロスポリンのｎ，ｎ−ジメチルアセトアミド付加体及びその製法
HU184631B (en) * 1978-05-26 1984-09-28 Glaxo Group Ltd Process for preparing cef-3-em-4-carboxylic acid derivatives with antiaiotic activity
AR229883A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato
ZA803093B (en) * 1979-05-25 1981-07-29 Glaxo Group Ltd Intermediates for use in the preparation of cephalosporin antibiotics
ATE31532T1 (de) * 1982-04-29 1988-01-15 Glaxo Group Ltd Thiazolderivat, verfahren zu seiner herstellung sowie seine verwendung bei der herstellung von beta-lactam-antibiotika.

Also Published As

Publication number Publication date
EP0113568A3 (en) 1985-07-31
IE56485B1 (en) 1991-08-14
DE3381408D1 (de) 1990-05-10
DK164061B (da) 1992-05-04
DK584183A (da) 1984-06-28
EP0113568B1 (en) 1990-04-04
JPH069647A (ja) 1994-01-18
CA1245629A (en) 1988-11-29
DK164061C (da) 1992-09-28
IE833037L (en) 1984-06-27
IL70470A (en) 1988-04-29
DK584183D0 (da) 1983-12-19
GB8333667D0 (en) 1984-01-25
HK17089A (en) 1989-03-03
HU191911B (en) 1987-04-28
IL70470A0 (en) 1984-03-30
GB2132616A (en) 1984-07-11
EP0113568A2 (en) 1984-07-18
HUT34209A (en) 1985-02-28
KR840007013A (ko) 1984-12-04
GR79485B (enExample) 1984-10-30
US4525587A (en) 1985-06-25
JPH0834744B2 (ja) 1996-03-29
KR870000612B1 (ko) 1987-03-25
JPS59130889A (ja) 1984-07-27

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20021216