AT388736B - Neue stabile, kristalline formen des ceftazidime-t-butylesters und verfahren zu ihrer herstellung - Google Patents
Neue stabile, kristalline formen des ceftazidime-t-butylesters und verfahren zu ihrer herstellungInfo
- Publication number
- AT388736B AT388736B AT256687A AT256687A AT388736B AT 388736 B AT388736 B AT 388736B AT 256687 A AT256687 A AT 256687A AT 256687 A AT256687 A AT 256687A AT 388736 B AT388736 B AT 388736B
- Authority
- AT
- Austria
- Prior art keywords
- ceftazidime
- preparation
- butyl ester
- crystalline forms
- stable crystalline
- Prior art date
Links
- KRTGQDGIPNXUGP-ZLQBWVSZSA-N (6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[2-methyl-1-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]oxyiminoacetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Chemical compound S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC(C)(C)C(=O)OC(C)(C)C)C=2N=C(N)SC=2)CC=1C[N+]1=CC=CC=C1 KRTGQDGIPNXUGP-ZLQBWVSZSA-N 0.000 title 1
- 229960000484 ceftazidime Drugs 0.000 abstract 1
- NMVPEQXCMGEDNH-TZVUEUGBSA-N ceftazidime pentahydrate Chemical compound O.O.O.O.O.S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC(C)(C)C(O)=O)C=2N=C(N)SC=2)CC=1C[N+]1=CC=CC=C1 NMVPEQXCMGEDNH-TZVUEUGBSA-N 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT256687A AT388736B (de) | 1987-10-08 | 1987-10-08 | Neue stabile, kristalline formen des ceftazidime-t-butylesters und verfahren zu ihrer herstellung |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT256687A AT388736B (de) | 1987-10-08 | 1987-10-08 | Neue stabile, kristalline formen des ceftazidime-t-butylesters und verfahren zu ihrer herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA256687A ATA256687A (de) | 1989-01-15 |
| AT388736B true AT388736B (de) | 1989-08-25 |
Family
ID=3536571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT256687A AT388736B (de) | 1987-10-08 | 1987-10-08 | Neue stabile, kristalline formen des ceftazidime-t-butylesters und verfahren zu ihrer herstellung |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT388736B (de) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102391289A (zh) * | 2011-12-03 | 2012-03-28 | 齐鲁安替制药有限公司 | 头孢他啶中间体及头孢他啶的合成方法 |
| CN105646541A (zh) * | 2015-12-30 | 2016-06-08 | 中山市金城道勃法制药有限公司 | 一种原研制品质头孢他啶及其药物制剂 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117700430A (zh) * | 2023-12-11 | 2024-03-15 | 哈药集团技术中心 | 一种降低头孢他啶杂质h的工艺方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0113568A2 (de) * | 1982-12-27 | 1984-07-18 | Eli Lilly And Company | Zwischenverbindungen für die Herstellung von Ceftazidin und Verfahren zu ihrer Herstellung |
| EP0166580A2 (de) * | 1984-06-25 | 1986-01-02 | Eli Lilly And Company | Herstellung von Ceftazidine |
-
1987
- 1987-10-08 AT AT256687A patent/AT388736B/de not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0113568A2 (de) * | 1982-12-27 | 1984-07-18 | Eli Lilly And Company | Zwischenverbindungen für die Herstellung von Ceftazidin und Verfahren zu ihrer Herstellung |
| EP0166580A2 (de) * | 1984-06-25 | 1986-01-02 | Eli Lilly And Company | Herstellung von Ceftazidine |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102391289A (zh) * | 2011-12-03 | 2012-03-28 | 齐鲁安替制药有限公司 | 头孢他啶中间体及头孢他啶的合成方法 |
| CN102391289B (zh) * | 2011-12-03 | 2013-09-18 | 齐鲁安替制药有限公司 | 头孢他啶中间体及头孢他啶的合成方法 |
| CN105646541A (zh) * | 2015-12-30 | 2016-06-08 | 中山市金城道勃法制药有限公司 | 一种原研制品质头孢他啶及其药物制剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| ATA256687A (de) | 1989-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |